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Phenylephrine

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Identification
Molecular formula
C9H13NO2
CAS number
59-42-7
IUPAC name
3-(2-amino-1-hydroxy-propyl)phenol
State
State

At room temperature, the compound remains in a solid state. It is often available in its hydrochloride salt form, which is more stable and soluble.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
337.10
Boiling point (Kelvin)
610.25
General information
Molecular weight
167.21g/mol
Molar mass
167.2070g/mol
Density
1.1330g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is commonly found in its hydrochloride salt form, which enhances its solubility in water.

Comment on solubility

Solubility of 3-(2-amino-1-hydroxy-propyl)phenol

The solubility of 3-(2-amino-1-hydroxy-propyl)phenol, with the chemical formula C9H13NO2, can be influenced by its unique structural properties. This compound features both hydrophilic (water-attracting) and hydrophobic (water-repelling) regions, which can affect how it interacts with solvents.

In general, the following points are noteworthy regarding the solubility of this compound:

  • Hydrophilicity: The presence of the amino group (-NH2) and hydroxyl group (-OH) contributes to its ability to engage in hydrogen bonding with water molecules, making it more soluble in polar solvents.
  • Hydrophobic Interactions: The aromatic ring may create some hydrophobic character, potentially reducing solubility in purely aqueous environments.
  • Environmental pH: The solubility might also be affected by the pH of the surrounding environment, as the ionization state of the amino group can vary, altering overall solubility.

As a result, while 3-(2-amino-1-hydroxy-propyl)phenol is likely to show reasonable solubility in water due to its functional groups, it may exhibit reduced solubility in non-polar solvents. In conclusion, the solubility characteristics of this compound illustrate the fascinating interplay between its chemical structure and environmental factors.

Interesting facts

Interesting Facts about 3-(2-amino-1-hydroxy-propyl)phenol

3-(2-amino-1-hydroxy-propyl)phenol, often simply referred to as a derivative of phenol, is a fascinating compound with a variety of applications in both biological and chemical contexts. Here are some noteworthy points about this compound:

  • Biological Relevance: This compound is known for its role in biological systems, particularly as a precursor in the synthesis of various neurotransmitters and important biochemical compounds.
  • Pharmaceutical Applications: Due to its structure, this compound has potential uses in the pharmaceutical industry where it may act as a drug candidate or serve as an intermediate in the synthesis of other therapeutic agents.
  • Antioxidant Properties: The presence of the hydroxyl group in its structure is crucial, as it enables the compound to exhibit antioxidant properties, scavenging free radicals that can cause cellular damage.
  • Safety and Toxicology: Understanding the toxicological profile of such compounds is essential. While many phenolic compounds have potential health benefits, they also require careful handling due to possible cytotoxic effects at higher concentrations.
  • Exploration in Research: Scientists are exploring the compound's interactions at the molecular level, providing valuable insights into how modifications to its structure can enhance its efficacy or reduce toxicity.

As a student or researcher in the field of chemistry, one might find it intriguing to delve into the synthetic pathways that lead to the formation of 3-(2-amino-1-hydroxy-propyl)phenol and its derivatives. The compound serves as a fascinating example of how minor structural changes can lead to vastly different properties and applications.

Quotes from researchers working with this compound often highlight its importance: "Understanding the nuances of phenolic compounds like this one can unlock new avenues in drug discovery and development."

Synonyms
3-(2-Amino-1-hydroxypropyl)phenol
7619-17-2
21480-44-4
m-Hydroxynorephedrine
(+)-Metaraminol
meta-Hydroxynorephedrine
(1r,2r)-1-(m-hydroxyphenyl)-2-amino-1-propanol
CHEMBL29829
SCHEMBL3148045
Benzenemethanol, .alpha.-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-
DTXSID50858992
WXFIGDLSSYIKKV-UHFFFAOYSA-N
AAA06159
WAA48043
AKOS009208228
3-(2-Amino-1-hydroxypropyl)phenol-, (-)- #
1-.alpha.-(1-Aminoethyl)-m-hydroxybenzyl alcohol
L001281
Q4847848
(-)-.alpha.-(1-Aminoethyl)-m-hydroxybenzyl alcohol
F2173-0939
Benzyl alcohol, .alpha.-(1-aminoethyl)-m-hydroxy-, (-)-
20890-83-9