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Ruboxistaurin

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Identification
Molecular formula
C24H26N4O2
CAS number
169939-93-9
IUPAC name
3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
State
State

At room temperature, Ruboxistaurin is typically found in a solid state. It's employed as a pharmaceutical compound and may be handled in a controlled laboratory or manufacturing settings.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
392.60
Boiling point (Kelvin)
665.75
General information
Molecular weight
434.50g/mol
Molar mass
434.4980g/mol
Density
1.3490g/cm3
Appearence

3-[2-(4-Methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one, also known as Ruboxistaurin, is typically a colored crystalline solid that may appear white to off-white in its pure form. Its precise appearance can vary based on the level of purity and the presence of impurities.

Comment on solubility

Solubility of 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

The solubility of the compound C24H26N4O2 is an essential aspect to consider for its practical applications. Understanding solubility can provide insights into how this compound behaves in various environments. Here are some key points to consider about its solubility:

  • Solvent Dependency: The solubility of this compound is likely to vary significantly depending on the solvent used. Common solvents to evaluate include water, ethanol, and dimethyl sulfoxide (DMSO).
  • Hydrophobic Interactions: Given its complex structure, it is anticipated that the presence of aromatic rings may influence hydrophobic interactions, potentially leading to lower solubility in aqueous solutions.
  • pH Influence: Solubility may also be affected by the pH of the environment, as functional groups in the compound can interact with protons, altering solubility characteristics.

Further studies would be beneficial to delineate the precise solubility profile of this intriguing compound. Determining “how much” of this compound can dissolve in specific solvents is crucial for both laboratory experiments and pharmaceutical formulations.

In conclusion, the solubility of C24H26N4O2 is influenced by multiple factors, making a thorough understanding of its solubility essential for its practical utilization.

Interesting facts

Interesting Facts about 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

This intriguing compound, with its complex name, represents an interesting blend of chemical functionalities that make it a topic of research in various scientific fields. Below are some fascinating aspects of this molecule:

  • Multifunctionality: The structure features both benzimidazole and pyridazinone moieties, which are known for their biological activities, including antimicrobial and anti-inflammatory properties.
  • Pharmaceutical Potential: Compounds with similar structures often play a significant role in drug discovery. They may exhibit effects on a variety of biological mechanisms, which can be targeted for therapeutic interventions.
  • Structure-Activity Relationship (SAR): The diversity in the chemical scaffolds presents an opportunity to explore how modifications can change the biological activity, enhancing the efficacy and specificity of the compound.
  • Research Significance: According to recent studies, compounds containing both benzimidazole and pyridazine structures have shown promising results in treating various diseases, making this compound an interesting candidate for further exploration.
  • Synthetic Approaches: The synthesis of such complex structures involves advanced synthetic techniques, often incorporating multistep reactions. This highlights the skill and creativity involved in modern organic chemistry.

In conclusion, 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one is not only a fascinating compound due to its structural diversity but also holds significant potential in the realms of medicinal chemistry and pharmacology. As scientists continue to uncover the secrets locked within its molecular framework, it paves the way for the development of innovative therapeutic agents.

Synonyms
pimobendan
74150-27-9
pimobendane
Acardi
dl-Pimobendan
Vetmedin
d-Pimobendan
Pimobendan, (-)-
(-)-Pimobendan
Pimobendanum
l-Pimobendan
Racemic pinobendan
(+)-Pimobendan
UD-CG 115
118428-37-8
UD-CG-115BS
Racemic pimobendan
UD-CG 115 BS
Pimobendan, (+)-
Pimobendan (Vetmedin)
UDCG-115
118428-38-9
UD-CG-115
Pimobendan [INN-Spanish]
Pimobendane [INN-French]
Pimobendanum [INN-Latin]
UNII-34AP3BBP9T
6-(2-(4-METHOXYPHENYL)-1H-BENZO[D]IMIDAZOL-5-YL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE
34AP3BBP9T
3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
CHEBI:32003
BRN 4207330
CHEMBL24646
rac Pimobendan
613JXV89SU
9HTU209Z0N
DTXSID8048280
3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-, (+)-
3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-, (-)-
6-(2-(4-Methoxyphenyl)-4,5-dihydro-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
FORTEKOR PLUS COMPONENT PIMOBENDAN
Pimobendan (INN-Spanish)
Pimobendane (INN-French)
Pimobendanum (INN-Latin)
PIMOBENDAN (MART.)
PIMOBENDAN [MART.]
3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-
6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
PIMOBENDAN (USP-RS)
PIMOBENDAN [USP-RS]
PIMOBENDAN (EP IMPURITY)
PIMOBENDAN [EP IMPURITY]
PIMOBENDAN (USP MONOGRAPH)
PIMOBENDAN [USP MONOGRAPH]
PIMOBENDAN (EMA EPAR VETERINARY)
PIMOBENDAN [EMA EPAR VETERINARY]
3(2H)-PYRIDAZINONE, 4,5-DIHYDRO-6-(2-(4-METHOXYPHENYL)-1H-BENZIMIDAZOL-5-YL)-5-METHYL-, (+/-)-
3(2H)-PYRIDAZINONE, 4,5-DIHYDRO-6-(2-(4-METHOXYPHENYL)-1H-BENZIMIDAZOL-6-YL)-5-METHYL-
(+)-UD-CG 115BS
(-)-UD-CG 115BS
NCGC00274063-01
UNII-613JXV89SU
UNII-9HTU209Z0N
VetmedinChew
Pimobendan [USAN:INN:BAN]
Pimobendan?
Pimobendan,USP
Pimobendan EP5
6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
Vetmedin-CA1
Acardi (TN)
MFCD00761648
4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
Pimobendan (Standard)
SolutitionKitsPimobendan
PIMOBENDAN [MI]
PIMOBENDAN [INN]
PIMOBENDAN [JAN]
PIMOBENDAN [USAN]
(+)-4,5-Dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
(-)-4,5-Dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
6-(2-(4-methoxyphenyl)-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
PIMOBENDAN [WHO-DD]
SCHEMBL27623
MLS006010188
Pimobendan (JAN/USAN/INN)
PIMOBENDAN [GREEN BOOK]
DTXCID9028255
Pimobendan, >=98% (HPLC)
HY-B0204R
GLBJJMFZWDBELO-UHFFFAOYSA-N
HMS3655I03
HMS3884C21
KUC109647N
BCP02958
HY-B0204
AC-689
BDBM50282617
s1550
AKOS015851937
AKOS015967705
CCG-267853
DB11450
FP38260
KS-1280
4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazole-5-yl)-5-methyl-3(2H)-pyridazinone
KSC-210-009
NCGC00274063-04
NCGC00274063-05
118428-36-7
Pimobendan 100 microg/mL in Acetonitrile
SMR002530068
BCP0726000255
DB-219709
P2779
PIMOBENDAN COMPONENT OF FORTEKOR PLUS
SW219717-1
D01133
SBI-0654181.0001
AB01274800-01
AB01274800_02
EN300-27067685
Q414351
BRD-A84575140-001-02-4
Pimobendan, United States Pharmacopeia (USP) Reference Standard
4,5-dihydro-6-[2-(4-methoxy-phenyl)-1h-benzimidazol-5-yl]-5-methyl-3 (2h)-pyridazinone
4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
6-[2-(4-Methoxyphenyl)-3H-benzimidazol-5-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one
Pimobendan for system suitability, European Pharmacopoeia (EP) Reference Standard
(+/-)-4,5-DIHYDRO-6-(2-(P-METHOXYPHENYL)-5-BENZIMIDAZOLYL)-5-METHYL-3(2H)-PYRIDAZINONE
6-[2-(4-methoxyphenyl)-1H-1,3-benzodiazol-6-yl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one