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Fenofibrate

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Identification
Molecular formula
C20H21Cl2O4
CAS number
49562-28-9
IUPAC name
3-[2-(4-chlorophenoxy)-2-methyl-propanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methyl-propanoate
State
State

At room temperature, Fenofibrate is in a solid crystalline form.

Melting point (Celsius)
79.00
Melting point (Kelvin)
352.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
360.83g/mol
Molar mass
360.8310g/mol
Density
1.1978g/cm3
Appearence

Fenofibrate is a white or almost white crystalline powder. It is almost practically insoluble in water, but slightly soluble in acetone, ethanol, methanol, and chloroform.

Comment on solubility

Solubility of 3-[2-(4-chlorophenoxy)-2-methyl-propanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methyl-propanoate

The solubility of the compound C20H21Cl2O4, known as 3-[2-(4-chlorophenoxy)-2-methyl-propanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methyl-propanoate, is an important characteristic that affects its applications. Its solubility can be influenced by various factors, including:

  • Polarity: This compound contains both hydrophobic (chlorophenoxy groups) and hydrophilic (propanoate ester) regions, which can affect its overall solubility in water.
  • Solvent Type: In organic solvents, it is likely to be more soluble compared to its solubility in aqueous environments, suggesting a preference for non-polar or weakly polar solvents.
  • Temperature: The solubility may increase with temperature, as is common with many organic compounds.

Generally, compounds with similar structures exhibit low to moderate aqueous solubility. It has been observed that:

  1. The presence of chlorine atoms can impact solubility due to their electronegativity and steric hindrance.
  2. Compounds with large, bulky groups such as phenoxy typically demonstrate lower solubility in water.
  3. Interactions with polar solvents can sometimes enhance solubility due to the formation of hydrogen bonds.

In summary, while specific solubility data for this compound may not be readily available, it is reasonable to infer that it exhibits limited solubility in water but may exhibit enhanced solubility in organic solvents, making it versatile for various applications.

Interesting facts

Interesting Facts about 3-[2-(4-chlorophenoxy)-2-methyl-propanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methyl-propanoate

This compound is a fascinating example of how intricate molecular structures can lead to unique chemical properties and potential applications. Here are some notable facts:

  • Pharmaceutical Potential: Compounds with chlorophenoxy groups are often researched for their biological activity. This structure could envisage promising implications in drug development.
  • Synthetic Versatility: The incorporation of various substituents, such as the chlorophenoxy and methyl groups, hints at a versatile synthetic pathway that might facilitate the creation of other derivatives with modified properties.
  • Mechanistic Insights: Understanding the mechanism of this compound can provide insights into its reactivity and stability, which is essential in the field of synthetic chemistry.
  • Environmental Impact: Chlorinated compounds can have different environmental interactions, potentially leading to ecological concerns. Therefore, studying the biodegradability and toxicity of this compound is crucial.
  • Chemical Stability: Chlorine atoms are known for enhancing the stability of compounds, which might be an aspect to explore in storage and handling.

As a scientist, one might consider the balance of properties this compound presents: the intricate design suggests possibilities in applications ranging from agriculture—where similar compounds are used as herbicides—to medicine, where such structures can function as intermediates in the synthesis of pharmacologically active agents. Engagement with this compound opens a broader discussion on the impact of structure on function in chemistry.

In conclusion, the study of 3-[2-(4-chlorophenoxy)-2-methyl-propanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methyl-propanoate not only enriches our understanding of organic chemistry but also emphasizes the importance of exploring the relationship between molecular structure and biological activity.

Synonyms
simfibrate
14929-11-4
Cholesolvin
Sinfibrate
Simfibratum
Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate)
Sinfibrato
CLY-503
Simfibrate [INN:JAN]
Simfibratum [INN-Latin]
Sinfibrato [INN-Spanish]
EINECS 238-998-7
Simfibrato
Cholesolvin (TN)
BRN 1897652
DICLOFIBRATE
L2R75RQX26
DTXSID8057647
SIMFIBRATE [MI]
SIMFIBRATE [INN]
SIMFIBRATE [JAN]
SIMFIBRATE [MART.]
SIMFIBRATE [WHO-DD]
1,3-Propanediol bis(alpha-(p-chlorophenoxy)isobutyrate)
DTXCID9031436
1,3-Propanediol bis(2-(4-chlorophenoxy)-2-methylpropionate)
2-(p-Chlorophenoxy)-2-methylpropionic acid trimethylene ester
2-(4-Chlorophenoxy)-2-methylpropanoic acid 1,3-propanediyl ester
Simfibratum (INN-Latin)
Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 1,3-propanediyl ester
Sinfibrato (INN-Spanish)
SIMFIBRATE (MART.)
Trimethylene bis(2-(4-chlorophenoxy)-2-methylpropanoate)
Trimethylene bis[2-(4-chlorophenoxy)-2-methylpropanoate]
UNII-L2R75RQX26
CLY 503
3-((2-(4-chlorophenoxy)-2-methylpropanoyl)oxy)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
3-{[2-(4-chlorophenoxy)-2-methylpropanoyl]oxy}propyl 2-(4-chlorophenoxy)-2-methylpropanoate
Simfibrate (JAN/INN)
3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate
SCHEMBL27667
1,3-propanediol bis(alpha-p-chlorophenoxyisobutyrate)
CHEMBL2105435
CHEBI:32131
C10AB06
JLRNKCZRCMIVKA-UHFFFAOYSA-N
Tox21_113699
AKOS016014101
DB13433
NCGC00249923-01
CAS-14929-11-4
NS00024887
D01212
Q4117078
238-998-7