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Clavulanic acid

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Identification
Molecular formula
C8H9NO5
CAS number
58001-44-8
IUPAC name
3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]propanoylamino]-5-chloro-4-oxo-pentanoic acid
State
State

At room temperature, clavulanic acid is typically in a solid state. In its pure form, it is a crystalline solid, but it is often encountered in a mixture form for use in medications.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
354.00
Boiling point (Kelvin)
627.15
General information
Molecular weight
199.16g/mol
Molar mass
199.6520g/mol
Density
1.1800g/cm3
Appearence

Clavulanic acid is a white to light yellow crystalline substance. It is commonly encountered in its sodium salt form as sodium clavulanate, which is a more stable form used in commercial antibiotic compositions.

Comment on solubility

Solubility of 3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]propanoylamino]-5-chloro-4-oxo-pentanoic acid (C8H9NO5)

The solubility of the compound 3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]propanoylamino]-5-chloro-4-oxo-pentanoic acid, with the chemical formula C8H9NO5, is influenced by several factors:

  • Hydrophilicity: The presence of polar functional groups such as amides and carboxylic acids increases the compound's affinity for water, suggesting it may be soluble in aqueous solutions.
  • pH Sensitivity: The solubility can vary significantly with changes in pH due to the involvement of ionizable groups, especially the carboxylic acid.
  • Solvent Interaction: The solubility may be enhanced in certain organic solvents or mixed solvents, reflecting the importance of the solvent system in dissolving this compound.

In general, while this compound may exhibit moderate solubility in water due to its ionic and polar characteristics, it is essential to conduct experimental analyses to determine its precise solubility profile under various conditions. As a rule of thumb, and as noted by many researchers, “the solubility of a compound in a given solvent is a fundamental property that ensures its bioavailability and efficacy in pharmaceutical applications.”

Understanding the solubility mechanisms behind this complex molecular structure can elucidate its behavior in biological systems and enhance its utility in various applications.

Interesting facts

Interesting Facts about 3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-butanoyl]amino]propanoylamino]-5-chloro-4-oxo-pentanoic acid

This compound is a complex derivative that showcases the beautiful intricacies of organic chemistry, particularly within the realm of amino acids and their modifications. Here are some fascinating insights:

  • Structural Complexity: The presence of multiple functional groups makes this compound a fascinating subject for chemical study. It includes an acetamido group, which is essential for its biological activity.
  • Potential Applications: Due to its structural components, this compound could potentially be studied for its pharmacological properties, especially in regards to its interaction with various biological systems.
  • Chlorinated Compounds: The inclusion of a chlorine atom in the structure could impart unique reactivity and properties that make it suitable for specific applications in medicinal chemistry.
  • Amino Acid Analog: As a derivative of amino acids, it may play a role in understanding protein synthesis and the design of peptide-based drugs.
  • Research Implications: Compounds like this are often targets in drug discovery, particularly in the fields of cancer research and metabolic disorders, given its structural similarity to various bioactive molecules.

In the words of famous chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” The exploration of such compounds can lead to groundbreaking discoveries that advance our understanding of chemistry and biology. As you study this compound, consider how each modification influences its function and potential applications.

Synonyms
Caspase-1 Inhibitor II;
SCHEMBL19970821
IAT-3166-V
Ac-Tyr-Val-Lys-Asp-H (aldehyde)
Acetyl-L-Tyrosyl-L-Valyl-L-Lysyl-L-Aspart-1-al