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Bis(indolyl)methane

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Identification
Molecular formula
C17H14N2
CAS number
1531-96-2
IUPAC name
3-(1H-indol-3-ylmethyl)-1H-indole
State
State

At room temperature, bis(indolyl)methane is typically found as a solid. It is stable under normal conditions, making it suitable for storage and handling at room temperature.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
381.00
Boiling point (Kelvin)
654.15
General information
Molecular weight
256.31g/mol
Molar mass
256.3110g/mol
Density
1.2705g/cm3
Appearence

Bis(indolyl)methane appears as a crystalline solid that is typically off-white to pale yellow in color. Its appearance may vary slightly based on the degree of purity and the method of preparation used.

Comment on solubility

Solubility of 3-(1H-indol-3-ylmethyl)-1H-indole

The solubility of 3-(1H-indol-3-ylmethyl)-1H-indole (C17H14N2) is an interesting aspect to consider, especially given its structural characteristics. This compound, featuring two indole rings, exhibits unique interactions with solvents that influence its solubility.

Here are some key points to consider regarding its solubility:

  • Polarity: The presence of nitrogen atoms in the indole structure can create polar regions which may enhance solubility in polar solvents, while the overall hydrophobic nature of the indole rings may limit solubility in highly polar environments.
  • Solvent Compatibility: 3-(1H-indol-3-ylmethyl)-1H-indole is likely to be more soluble in organic solvents such as ethanol, dichloromethane, and dimethyl sulfoxide (DMSO), compared to water.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, which is a common observation in many organic solvents.
  • Applications: The solubility profile of this compound is particularly important in pharmaceutical formulations, where solubility can greatly influence bioavailability.

In summary, the solubility of 3-(1H-indol-3-ylmethyl)-1H-indole suggests that its behavior in various solvents is influenced by its molecular structure, making it essential to assess solubility under specific conditions for accurate applications in research and development.

Interesting facts

Exploring 3-(1H-indol-3-ylmethyl)-1H-indole

3-(1H-indol-3-ylmethyl)-1H-indole is a fascinating compound that captures the interest of chemists due to its intricate structure and potential biological activities. Here are some engaging facts about this unique molecule:

  • Structural Complexity: The compound features an indole core, which is a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The presence of multiple indole units can lead to intriguing electronic properties.
  • Biochemical Significance: Indole derivatives have been shown to possess a wide range of biological activities, from anti-cancer effects to antimicrobial properties. This makes 3-(1H-indol-3-ylmethyl)-1H-indole a compound of interest in medicinal chemistry.
  • Potential Applications: Its structural resemblance to various neurotransmitters could suggest a role in the central nervous system. Research is ongoing to explore its potential implications in treating mood disorders and neurological conditions.
  • Synthesis Pathways: The synthesis of such compounds often involves intricate organic reactions, showcasing the creativity and problem-solving skills required in organic chemistry.
  • Natural Occurrence: Indoles are found in natural products and are often associated with the smell of flowers and the aroma of certain food items, making them important in both the food and fragrance industries.

3-(1H-indol-3-ylmethyl)-1H-indole is a prime example of how a compound's structure can be intricately linked to its function and application in various fields, ranging from pharmaceuticals to materials science. As research advances, the capabilities and effects of this intriguing compound will no doubt continue to unfold.

Synonyms
3,3'-Diindolylmethane
1968-05-4
diindolylmethane
di(1H-indol-3-yl)methane
3,3'-Methylenebis-1H-indole
3,3'-Methylenediindole
DIM
1H-Indole, 3,3'-methylenebis-
3-(1H-indol-3-ylmethyl)-1H-indole
Plant Indole
ARUNDINE
3,3-Diindolylmethane
33'-Diindolylmethane
3,3'-Diindolymethane
Infemin
3,3'-methylenebis(1H-indole)
3,3'-Di-indolylmethane
SSZ9HQT61Z
bis-1H-indol-3-ylmethane
MFCD00195766
CCRIS 5806
Di(3-indolyl)methane
CHEBI:50182
3,3'-methanediylbis(1H-indole)
DIINDOLYLMETHANE [VANDF]
3,3 inverted exclamation marka-Diindolylmethane
DIINDOLYLMETHANE, 3,3'-
HB 236
3,3,-diindolylmethane
3,3'-DIINDOLYLMETHANE [WHO-DD]
Diidolylmethane
3-(1H-Indol-3-ylmethyl)-1H-indole;3,3'-Methylenebis-1H-indole
33diindolylmethyle
Di-Indoly Methane
DIM-Plus
Di-3-indolylmethane
NSC708486
DIMPRO
3-3-diindolylmethane
Bis (3-indolyl)methane
Spectrum2_001711
Spectrum3_001989
Spectrum5_001955
UNII-SSZ9HQT61Z
DIM;Arundine;HB 236
CBiol_001839
Oprea1_472633
Oprea1_740951
BSPBio_001290
BSPBio_003589
CBDivE_010856
KBioGR_000010
KBioSS_000010
MLS006011847
SCHEMBL325162
SPECTRUM1505331
SPBio_001722
3-3'-DIINDOLYLMETHANE
3,3'-di(indol-3-yl)methane
BML3-F11
CHEMBL446452
DTXSID8037047
3,3'-Diindolymethane (natural)
GTPL11208
KBio2_000010
KBio2_002578
KBio2_005146
KBio3_000019
KBio3_000020
KBio3_003002
3,3'-Diindolymethane (synthetic)
Bio1_000125
Bio1_000614
Bio1_001103
Bio2_000010
Bio2_000490
HMS1361A12
HMS1791A12
HMS1989A12
HMS3402A12
3,3'-Diindolylmethane (Standard)
ALBB-016048
BCP00470
CCG-39861
GR-207
HSCI1_000069
HY-15758R
s4728
STK263696
AKOS003627372
CS-1652
DB11875
FD14886
FD14887
KS-5266
NSC-708486
SB16901
IDI1_033760
NCGC00095348-01
NCGC00095348-02
NCGC00095348-03
NCGC00095348-04
NCGC00095348-05
NCGC00095348-06
NCGC00095348-07
3-[(1H-indol-3-yl)methyl]-1H-indole
AC-11611
HY-15758
NCI60_038418
SMR001828114
SY038972
3,3'-Diindolylmethane, >=98% (HPLC)
3,3'-Diindolylmethane, analytical standard
DB-011102
M1399
NS00026401
EN300-1717487
Q4634053
BRD-K37846922-001-05-2
BRD-K37846922-001-06-0
BRD-K37846922-001-09-4
Z56791159
3,3'-Diindolylmethane;di(1H-indol-3-yl)methane ;3,3'-methylene-bisindole