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3-(1-propyl-3-piperidyl)benzonitrile

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Identification
Molecular formula
C15H20N2
CAS number
91164-58-8
IUPAC name
3-(1-propyl-3-piperidyl)benzonitrile
State
State

3-(1-propyl-3-piperidyl)benzonitrile is a solid under standard conditions. Typically handled as a dry powder.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
370.85
Boiling point (Kelvin)
643.85
General information
Molecular weight
240.35g/mol
Molar mass
240.3510g/mol
Density
1.0200g/cm3
Appearence

3-(1-propyl-3-piperidyl)benzonitrile is typically characterized by its crystalline solid form. It appears as a white to off-white powder.

Comment on solubility

Solubility of 3-(1-propyl-3-piperidyl)benzonitrile

The solubility of 3-(1-propyl-3-piperidyl)benzonitrile (C15H20N2) can be quite interesting due to its unique structure. This compound is primarily classified as a non-polar organic molecule, which typically influences its interactions with solvents.

Key Factors Affecting Solubility

  • Polarity: The presence of a benzene ring contributes to the non-polar characteristics of the compound, making it less soluble in polar solvents like water.
  • Hydrophobic Interactions: The long carbon chain (propyl group) and the piperidine ring increase hydrophobic interactions, favoring solubility in non-polar organic solvents like ethanol, acetone, or chloroform.
  • Temperature: As with many organic compounds, an increase in temperature often enhances solubility in organic solvents due to increased molecular motion.

In practical terms, 3-(1-propyl-3-piperidyl)benzonitrile is expected to demonstrate low solubility in water, typically leading to the ruling out of water as a suitable solvent for dissolving this compound. Instead, for laboratory applications or formulation, it would be more effective to utilize non-polar or mildly polar organic solvents.

As a general conclusion: "Solubility is not just about what dissolves, but where and how it dissolves." Understanding these interactions can guide chemists in choosing the right solvents for mixing or experimentation.

Interesting facts

Interesting Facts about 3-(1-propyl-3-piperidyl)benzonitrile

3-(1-propyl-3-piperidyl)benzonitrile is an intriguing compound that has captured the interest of many within the fields of organic chemistry and medicinal chemistry. Here are some notable points about this compound:

  • Structural Significance: This compound features a unique structure comprising a benzene ring connected to a nitrile group and a piperidine derivative. This arrangement suggests potential interaction with biological targets due to its ability to mimic natural ligands.
  • Pharmacological Potential: Compounds similar to 3-(1-propyl-3-piperidyl)benzonitrile have been studied for their pharmacological effects, particularly concerning their application in treating neurological disorders. Its piperidine moiety is often associated with enhanced activity in various biological systems.
  • Chemical Applications: Beyond medicinal use, compounds like this one may also find roles in the synthesis of more complex molecules or serve as intermediates in organic reactions, contributing to the synthesis of pharmaceuticals and agrochemicals.
  • Research Exploration: Ongoing studies wish to explore the compound's properties further, examining not only its mechanism of action but also how slight modifications to the structure can influence its effectiveness and selectivity towards specific receptors.
  • Diverse Synthesis: The synthesis of such compounds involves various methods, often utilizing techniques like reductive amination and nucleophilic substitution which serve as essential pathways creating diverse chemical libraries.
  • In Silico Studies: Computational chemistry has permitted scientists to conduct in silico studies, predicting the interactions of this compound with biological macromolecules, which is particularly valuable for drug design.

In summary, 3-(1-propyl-3-piperidyl)benzonitrile is not just a simple compound but a gateway to understanding complex biological processes and developing therapeutic agents. As researchers delve deeper into its properties and applications, this compound stands as a testament to the innovation present in chemical science.

Synonyms
3-(1-propylpiperidin-3-yl)benzonitrile
150336-90-6
3-(3-Cyanophenyl)-N-n-propylpiperidine
3-(1-Propyl-3-piperidinyl)benzonitrile
CHEMBL107492
DS-121
DS121 Cpd
(-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile
SCHEMBL872942
DTXSID40933909
BDBM50041960
PD161676
3-(1-Propyl-piperidin-3-yl)-benzonitrile
(+)-3-(1-Propyl-piperidin-3-yl)-benzonitrile
L007862
Benzonitrile, 3-(1-propyl-3-piperidinyl)-, (+-)-