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Tacrine

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Identification
Molecular formula
C13H14N2
CAS number
321-64-2
IUPAC name
3-(1-piperidyl)-N-[6-[3-(1-piperidyl)propanoylamino]acridin-3-yl]propanamide
State
State

At room temperature, Tacrine is a solid. Specifically, it appears as a crystalline powder.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
446.30
Boiling point (Kelvin)
719.45
General information
Molecular weight
198.27g/mol
Molar mass
198.2660g/mol
Density
1.2600g/cm3
Appearence

Tacrine is typically a white to off-white crystalline powder. It is often used in its hydrochloride form, which is also a powder that may appear slightly yellowish.

Comment on solubility

Solubility of 3-(1-piperidyl)-N-[6-[3-(1-piperidyl)propanoylamino]acridin-3-yl]propanamide (C13H14N2)

When it comes to the solubility of 3-(1-piperidyl)-N-[6-[3-(1-piperidyl)propanoylamino]acridin-3-yl]propanamide, several factors can influence its behavior in solvents:

  • Polarity: The compound contains both polar and non-polar regions due to its piperidine and acridine structures, which can affect its solubility in various solvents.
  • Solvent type: This compound may exhibit different solubility in:
    • Water: Generally, such complex organic compounds have limited solubility in water unless they have highly polar groups.
    • Organic solvents: Solvents like methanol and DMSO might be more effective for dissolving this compound.
  • Temperature: Increasing temperature often enhances the solubility of organic compounds.
  • pH effects: The ionization state of the piperidine rings can change with pH, potentially increasing solubility in certain media.

To sum it up, the solubility of 3-(1-piperidyl)-N-[6-[3-(1-piperidyl)propanoylamino]acridin-3-yl]propanamide is likely to be moderate in organic solvents, while being relatively low in water, primarily due to its structure and functional groups.

Interesting facts

Interesting Facts About 3-(1-Piperidyl)-N-[6-[3-(1-piperidyl)propanoylamino]acridin-3-yl]propanamide

This compound is a fascinating molecule in the field of medicinal chemistry, primarily due to its complex structure and potential therapeutic applications. Here are some notable aspects:

  • Structure Complexity: The compound features not only aromatic rings but also piperidine rings, making it an interesting target for synthesis and modification in drug discovery.
  • Potential Biological Activity: Compounds like this are often investigated for their activity against various diseases, particularly those involving the central nervous system or cancer.
  • Research Insights: Scientists are exploring the mechanism by which such molecules interact with biological systems, aiming to elucidate their therapeutic effects.
  • Ligand Development: The presence of piperidyl and acridinyl groups suggests potential utility as ligands for various receptors, paving the way for innovative developments in pharmacology.
  • Synergistic Effects: The combination of different functional groups in this molecule may lead to synergistic effects, enhancing biological activity in comparison to simpler analogs.

As noted by researchers, "The design of multi-functional compounds offers vast potential in addressing complex biological targets." This compounds' intricate architecture positions it as a promising candidate in the ongoing pursuit of effective therapeutic agents.

For students and budding scientists, understanding the synthesis and application of such compounds enriches their knowledge of structure-activity relationships in pharmacology. Exploring the chemistry behind them can stimulate new ideas for future research endeavors.

Synonyms
CHEMBL81268
3,6-Bis(3-piperidinopropionamido)acridine
SCHEMBL3116872
BDBM50080847
N,N''-(acridine-3,6-diyl)bis(3-(piperidin-1-yl)propanamide)
3-Piperidin-1-yl-N-[6-(3-piperidin-1-yl-propionylamino)-acridin-3-yl]-propionamide