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Nicotine N-oxide

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Identification
Molecular formula
C10H14N2O
CAS number
1008-84-2
IUPAC name
3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine
State
State

At room temperature, Nicotine N-oxide is typically found in a solid state.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
178.24g/mol
Molar mass
178.2340g/mol
Density
1.1620g/cm3
Appearence

Nicotine N-oxide is typically seen as a white solid crystalline substance. The compound's appearance may vary slightly depending on its purity and the specific form it is in.

Comment on solubility

Solubility of 3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine

The solubility of the compound 3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine (C10H14N2O) can be quite intriguing. As with many organic compounds, solubility is influenced by several factors including molecular structure, polarity, and the presence of functional groups.

Key Factors Influencing Solubility:

  • Polarity: The presence of the oxido-pyrrolidin-1-ium moiety introduces polar characteristics that generally enhance solubility in polar solvents.
  • Hydrogen Bonding: This compound can engage in hydrogen bonding due to the nitrogen and oxygen atoms, promoting interactions with solvents that can accept hydrogen bonds.
  • Hydrophilic vs. Hydrophobic Balance: The balance between the hydrophilic pyridine ring and the potentially hydrophobic alkyl components can affect overall solubility, indicating possible favorable solubility in both polar and non-polar solvents depending on the specific interactions.

In summary, while the solubility of 3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine can be anticipated to be relatively good in polar solvents, especially due to its ionic features, a more detailed study is essential to determine its solubility in various solvent systems. As a quote summarizing solubility, it can be said that "like dissolves like", highlighting the importance of matching solvent polarity with that of the solute.

Interesting facts

Interesting Facts About 3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine

3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine stands out as a fascinating compound in the realm of organic chemistry. Here are some captivating aspects of this unique compound:

  • Structural Intricacy: The compound features a pyridine ring—a key structure in various natural and synthetic chemicals—combined with a pyrrolidine moiety. This fusion results in rich chemical diversity and potential reactivity.
  • Bioactivity: Compounds like 3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine are often examined for their biological properties. The presence of the nitrogen atoms in both the pyridine and pyrrolidine rings may contribute to its potential pharmaceutical properties.
  • Electrophilic Nature: The nitrogen atom in the pyridine ring can participate in various electrophilic aromatic substitution reactions. This makes the compound a valuable intermediate in the synthesis of more complex molecules.
  • Research Significance: Many studies explore compounds with similar structures for their roles in drug design, especially in neuropharmacology and antioxidant activity due to their nitrogen-rich framework.
  • Synthesis Challenges: The synthetic routes to create this compound can be demanding, involving multiple steps. Mastery of these synthesis pathways enhances a chemist’s skills in navigating organic reactions.

3-(1-methyl-1-oxido-pyrrolidin-1-ium-2-yl)pyridine showcases the intricate balance of structure and function that is central to the field of chemistry. As scientists delve deeper into its properties, the compound's versatility in drug design and synthesis will likely unveil even more thrilling possibilities.

Synonyms
Nicotine 1-N-oxide
63551-14-4
3-(1-methyl-1-oxidopyrrolidin-1-ium-2-yl)pyridine
nicotine N(1')-oxide
Nicotine-1'-oxide
3-(1-Methyl-1-oxido-2-pyrrolidinyl)pyridine
SNICOTINEN1OXIDE
1-methyl-2-(3-pyridyl)pyrrolidine 1-oxide
Nicotine 1'-N-oxide
3-(1-methyl-1-oxidopyrrolidin-2-yl)pyridine
1-methyl-2-(3-pyridyl)-2,3,4,5-tetrahydropyrrol-1-olate
(-)-Nicotine 1'-oxide
(1's,2's)-Nicotine-N'-oxide
Oxynicotin
nicotine 1'-oxide
1'-oxide Nicotine
3-(1-Methyl-1-oxido-2-pyrrolidinyl)pyridine #
trans-Nicotine-1'-oxide
3-(1-Methyl-2-pyrrolidinyl)pyridine, N-oxide
Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, N-oxide, (2s)-
(-)-Nicotine 1'-N-oxide
SCHEMBL1538468
CHEBI:30734
DTXSID601262724
BCA02067
AKOS034834174
DA-56173
N-oxide-(1-Methyl-2-pyrrolidinyl)pyridine
DB-217568
NS00125161
N-oxide 3-(1-Methyl-2-pyrrolidinyl)pyridine
1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium-1-olate
(2S)-N-oxide 3-(1-methyl-2-pyrrolidinyl)-Pyridine
Q27113968
3-[(2S)-1-Methyl-1-oxido-pyrrolidin-1-ium-2-yl]pyridine