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Fluorophenibut

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Identification
Molecular formula
C27H27ClF2N4O
CAS number
262868-44-8
IUPAC name
3-[1-[4-(2-chloro-4-fluoro-phenyl)-4-(4-fluorophenyl)butyl]-4-piperidyl]-1H-benzimidazol-2-one
State
State

At room temperature, Fluorophenibut is typically found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
475.00
Boiling point (Kelvin)
748.15
General information
Molecular weight
482.92g/mol
Molar mass
482.9190g/mol
Density
1.2560g/cm3
Appearence

Fluorophenibut appears as a white crystalline powder. It is typically odorless and has a characteristic bitter taste.

Comment on solubility

Solubility of 3-[1-[4-(2-chloro-4-fluoro-phenyl)-4-(4-fluorophenyl)butyl]-4-piperidyl]-1H-benzimidazol-2-one

The solubility of the compound C27H27ClF2N4O, commonly referred to as a benzimidazole derivative, is an intriguing aspect of its chemical profile. Understanding its solubility behavior is crucial for various applications, especially in pharmaceuticals. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar Solvents: This compound tends to be more soluble in polar organic solvents due to the presence of polar functional groups such as the amine and carbonyl functionalities of the benzimidazole structure.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, making it more soluble in heated solvents.
  • pH Influence: Since this compound contains nitrogen, alterations in pH can affect solubility. An acidic environment may enhance solubility due to protonation of nitrogen atoms.
  • Potential for Formulation: The solubility profile suggests that this compound could be designed into various formulations, enhancing flexibility in drug delivery systems.

In conclusion, the solubility characteristics of C27H27ClF2N4O are essential to its functional application. A thorough understanding of its solubility can lead to optimized usage in various chemical and pharmaceutical contexts. As noted, exploring solubility in different solvents and conditions provides valuable insights into its potential.

Interesting facts

Interesting Facts about 3-[1-[4-(2-chloro-4-fluoro-phenyl)-4-(4-fluorophenyl)butyl]-4-piperidyl]-1H-benzimidazol-2-one

This compound belongs to a class of chemical compounds known as benzimidazoles, which are characterized by a fused benzene and imidazole ring. They demonstrate a wide array of biological activities, making them a significant subject of research in pharmacology.

Key Characteristics:

  • Pharmaceutical Applications: Benzimidazole derivatives often exhibit potent inhibitory actions against various targets in biological systems. This specific compound, for instance, has been studied for its potential in treating disorders related to the central nervous system.
  • Fluorinated Phenyl Groups: The presence of fluorine atoms in its structure enhances the electronic properties of the compound, potentially influencing its binding affinity and selectivity to specific biological targets.
  • Chlorine Substitution: The incorporation of chlorine introduces steric effects, which can significantly modulate the pharmacokinetics of the compound, making it both a subject of interest for medicinal chemistry and a fascinating example of halogenated molecule design.

Interestingly, the design of such compounds often reflects the balance between potency, selectivity, and toxicity. As quoted in one of the leading articles, “The ideal drug should be one that is effective at low doses and has minimal side effects.” Compounds like this one represent the ongoing quest for optimal therapeutics in modern medicine.

In addition to their medicinal implications, the chemical synthesis of such complex organic compounds challenges chemists to develop innovative synthetic pathways, showcasing the brilliance of chemical synthesis and the intricate web of organic reactivity.

Overall, 3-[1-[4-(2-chloro-4-fluoro-phenyl)-4-(4-fluorophenyl)butyl]-4-piperidyl]-1H-benzimidazol-2-one serves as an exemplary model for exploring the intersection of chemical ingenuity and therapeutic potential.

Synonyms
Bio1_001140
CBiol_001876
KBioGR_000159
KBioGR_002554
KBioSS_000159
KBioSS_002563
SCHEMBL14022556
KBio2_000159
KBio2_002554
KBio2_002727
KBio2_005122
KBio2_005295
KBio2_007690
KBio3_000317
KBio3_000318
KBio3_003032
cMAP_000081
Bio1_000162
Bio1_000651
Bio2_000159
Bio2_000639
HMS1361H21
IDI1_033909