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Tropacocaine

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Identification
Molecular formula
C16H23NO2
CAS number
6393-62-2
IUPAC name
[(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate
State
State

At room temperature, Tropacocaine is typically in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
48.00
Melting point (Kelvin)
321.15
Boiling point (Celsius)
235.90
Boiling point (Kelvin)
509.05
General information
Molecular weight
291.40g/mol
Molar mass
291.4020g/mol
Density
1.0070g/cm3
Appearence

Tropacocaine typically appears as a white crystalline powder. It is a synthetic derivative of cocaine and has a similar texture and physical appearance to other powdered alkaloids.

Comment on solubility

Solubility of [(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate

The compound with the formula C16H23NO2, commonly known as [(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate, exhibits unique solubility characteristics that are important to consider in various applications.

  • Solvent Dependency: The solubility of this compound can vary significantly depending on the solvent used. It is generally more soluble in organic solvents such as ethanol and dichloromethane, but may exhibit lower solubility in polar solvents like water.
  • Temperature Influence: As with many organic compounds, an increase in temperature can lead to enhanced solubility. Typically, one may observe increased solubility at elevated temperatures due to improved molecular motion and interaction.
  • Functional Groups: The presence of both hydrophilic and hydrophobic functional groups impacts its overall solubility profile. The piperidine and ester moieties may suffice to enhance solubility in certain conditions.
  • pH Sensitivity: The solubility may also be influenced by the pH of the surrounding environment, affecting ionization states of the functional groups. Hence, understanding the pH dependency is crucial for predicting solubility behavior.

To sum up, the solubility of [(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate is complex and influenced by various factors such as solvent type, temperature, functional groups, and pH level. Conducting thorough solubility assessments is recommended for its practical applications.

Interesting facts

Interesting Facts about [(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] Propanoate

[(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate is a fascinating compound that has garnered interest in both the fields of medicinal chemistry and organic synthesis. Here are some intriguing facts about this compound:

  • Chiral Centers: This compound contains two chiral centers at the 2 and 5 positions of the piperidine ring. This chirality contributes to its potential biological activity and can remarkably influence how it interacts with biological systems.
  • Pharmaceutical Applications: Compounds like these are often studied for their potential use in drug development, particularly for their effects on the central nervous system. The structural features noteworthy in this compound make it a candidate for research in treating neurological disorders.
  • Synthetic Strategies: The synthesis of such complex molecules typically involves multiple steps of organic reactions, showcasing the ingenuity of synthetic chemists. Understanding the reaction mechanisms can offer insights into modern synthetic approaches and strategies.
  • Functional Groups: The presence of different functional groups, including the piperidine and phenyl groups, indicates that this compound may exhibit diverse chemical reactivity and potential for various derivatives, which can be tailored for specific applications.
  • Research Potential: Ongoing research is being conducted to explore the therapeutic efficacy of such compounds. Their unique functionalization can lead to significant advancements in medicinal chemistry.

In summary, [(2S,5R)-1,2,5-trimethyl-4-phenyl-4-piperidyl] propanoate exemplifies the complexity and beauty of organic compounds, revealing a realm of potential applications and research opportunities. As noted by chemists, "The synthesis of chiral compounds is a testament to the creativity of the human mind and its ability to manipulate nature's building blocks." This statement perfectly encapsulates the scientific pursuit surrounding such interesting compounds.

Synonyms
Trimeperidine
Trimeperidina
Trimeperidinum
Trimeperidinum [INN-Latin]
Trimeperidina [INN-Spanish]
Promedol
Trimeperidine [INN:BAN:DCF]
1,2,5-Trimethyl-4-phenyl-4-propionoxypiperidine
4-Piperidinol, 4-phenyl-1,2,5-trimethyl-, propionate
1,2,5-Trimethyl-4-phenyl-4-piperidinol, propionate (ester)
EINECS 200-583-3
DTXSID501018271
4-PIPERIDINOL, 1,2,5-TRIMETHYL-4-PHENYL-, PROPIONATE (ester)
64-39-1
Trimeperidinum (INN-Latin)
Trimeperidin
Trimeperidina (INN-Spanish)
Isopromedol-
.gamma.-promedol
1,2,5-Trimethyl-4-phenyl-4-propionyloxypiperidine
DEA No. 9646
4-Piperidinol, 1,2,5-trimethyl-4-phenyl-, propanoate (ester)
PROMEDOL [MI]
IDS-NT-004
1,2,5-Trimethyl-4-phenyl-4-piperidinol, propionate
4-Piperidinol, 1,2,5-trimethyl-4-phenyl-, propanoate
4-Piperidinol, 1,2,5-trimethyl-4-phenyl-, propionate
SCHEMBL1649689
4-Piperidinol, 1,2,5-trimethyl-4-phenyl-, propanoate (ester), (2alpha,4beta,5beta)-
DTXCID301476495
promedolum (for the hydrochloride)
4-PIPERIDINOL, 1,2,5-TRIMETHYL-4-PHENYL-, PROPANOATE (ESTER), (2.ALPHA.,4.BETA.,5.BETA.)-
D06268
200-583-3