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Amphetamine sulfate

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Identification
Molecular formula
C18H28N2O4S
CAS number
60-13-9
IUPAC name
(2S)-1-phenylpropan-2-amine;sulfuric acid
State
State

Amphetamine sulfate is a solid at room temperature, typically found as a stable powder. It is administered in various forms, including tablets and capsules, due to its stability in solid form.

Melting point (Celsius)
300.00
Melting point (Kelvin)
573.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
368.50g/mol
Molar mass
368.4970g/mol
Density
1.2000g/cm3
Appearence

Amphetamine sulfate typically appears as a white to off-white crystalline powder. It may also appear granular and is usually devoid of any significant odor.

Comment on solubility

Solubility of (2S)-1-phenylpropan-2-amine; sulfuric acid

The solubility of the compound (2S)-1-phenylpropan-2-amine in the presence of sulfuric acid is influenced by its chemical structure and interactions with the solvent.

  • Polar vs. Nonpolar: The amine group contributes to the molecule's polarity, making it likely to have some level of solubility in polar solvents.
  • Concentration Effects: The presence of sulfuric acid can enhance the solubility of the amine due to protonation, which increases its solubility in water.
  • pH Dependence: At lower pH levels, the compound may become more soluble as it forms ionic species in acidic conditions.

In summary, the solubility of C18H28N2O4S is generally favorable in acidic solutions, where the interplay of polarity and ionic nature enhances its ability to dissolve. Therefore, it's often noted that:

"Solubility is not a static property; it varies with the chemical environment."

This emphasizes the importance of considering external conditions when evaluating solubility. Overall, the compound's behavior in solubility studies reflects the nuanced balance of its molecular features and the environment.

Interesting facts

Interesting Facts about (2S)-1-phenylpropan-2-amine; Sulfuric Acid

(2S)-1-phenylpropan-2-amine, often referred to as amphetamine, is a fascinating compound with a rich history and significant impact in both medical and recreational contexts. When combined with sulfuric acid, its properties can be greatly modified, showcasing the versatility of chemical interactions.

Key Characteristics

  • Medical Uses: Amphetamines have been used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy, demonstrating their importance in therapeutic applications.
  • Pharmacology: This compound functions primarily as a central nervous system stimulant, enhancing concentration and alertness, which is why it has been utilized in various study aids.
  • Effects: One of the notable effects of amphetamine is the release of neurotransmitters such as dopamine and norepinephrine, contributing to its stimulating properties.

Importance of Sulfuric Acid in Chemical Reactions

When (2S)-1-phenylpropan-2-amine interacts with sulfuric acid, several important reactions can occur:

  • Ionization: Sulfuric acid can protonate the amine group, making the compound more soluble in polar solvents and affecting its biological activity.
  • Formation of Salts: The reaction can lead to the formation of salt forms of amphetamines, which are often more stable and easier to handle in pharmaceutical formulations.
  • Hydration: Sulfuric acid can facilitate hydration reactions that may lead to new derivatives with enhanced properties.

Fun Fact

Amphetamines have played a role in various historical events, including their use by soldiers during World War II to combat fatigue and improve endurance.

In summary, the study of (2S)-1-phenylpropan-2-amine and its interactions with substances like sulfuric acid is not only crucial for understanding its multifaceted applications but also for appreciating the broader implications of chemistry in healthcare and society.

Synonyms
Dextroamphetamine sulfate
Dexampex
Ferndex
Dextroamphetamine sulphate
Ditab
Dexamphetamine sulfate
Betafedrine
Betaphedrine
Amphaetex
Ampherex
Amptrerex
Apetain
Dexaline
Dexamed
Dexamine
Dexedrina
Dextenal
Fastballs
Lipsoids
Lowedex
Obesonil
Oranges
Spancap
Cradex
Dasdel
Dexies
Robese
Dextroanfetamina
Medex
Perke
Tidex
Dams
Dexamphetamine sulphate
D-Amfetasul
Sympamina-D
Dex-Sule
Dex ob
Dexamfetamine sulfate
Dextroamphetamine Sulfate CII
d-Amphetamine sulphate
D-Amphetamine hemisulfate salt
(S)-Amphetamine sulfate
(+)-Amphetamine sulphate
JJ768O327N
d-alpha-Methylphenethylamine sulfate
EINECS 200-111-6
NSC 27104
NSC-27104
Dextro-Amphetamine Sulfate
Dextro-beta-phenylisopropylamine sulfate
Dextro-alpha-methylphenethylamine sulfate
(S)-alpha-Methylbenzeneethanamine sulfate
UNII-JJ768O327N
Dextroamphetamine sulfate (USP)
DTXSID2057865
CHEBI:51064
(+)-alpha-Methylphenethylamine sulfate (2:1)
d-Amphetamine.sulfate
Benzeneethanamine, alpha-methyl-, (S)-, sulfate (2:1)
Benzeneethanamine, alpha-methyl-, (alphaS)-, sulfate (2:1)
Dexamfetamine Hemisulfate
DELCOBESE COMPONENT DEXTROAMPHETAMINE SULFATE
Dextroamphetamine sulfate [USP]
Dellipsoids
Recordati
DEXAMFETAMINE SULFATE (MART.)
DEXAMFETAMINE SULFATE [MART.]
DEXAMFETAMINE SULFATE (EP MONOGRAPH)
DEXAMFETAMINE SULFATE [EP MONOGRAPH]
Medex (VAN)
DEXTROAMPHETAMINE SULFATE CII (USP-RS)
DEXTROAMPHETAMINE SULFATE CII [USP-RS]
DEXTROAMPHETAMINE SULFATE (USP MONOGRAPH)
DEXTROAMPHETAMINE SULFATE [USP MONOGRAPH]
(S)-Amphetamine Hemisulfate (1mg/ml in Methanol)
(S)-Amphetamine Hemisulfate (1mg/ml in Acetonitrile)
DAS (VAN)
Fabatin
Procentra
Zenzedi
Dextrostat (TN)
d-beta-Phenylisopropylamine sulfate
Dexedrine (TN)
DEXEDRINESPANSULE
alpha-Methylphenethylamine sulfate, d-form
Phenethylamine,alpha-methyl-, sulfate, (+)
Sulfate, Dextroamphetamine
(S)-amphetamine hemisulfate
(S)-amphetamine hemisulphate
SCHEMBL18948
Phenethylamine, alpha-methyl-, sulfate (2:1), (+)-
CHEMBL3544971
AMPHETAMINE SULFATE, DEXTRO
DTXCID801476919
DEXTROAMPHETAMINE SULFATE [MI]
AKOS024457301
DEXAMFETAMINE SULFATE [WHO-DD]
DEXTROAMPHETAMINE SULFATE [VANDF]
Dextroamphetamine SulfateExtended-Release
FA162453
D02078
DEXTROAMPHETAMINE SULFATE [ORANGE BOOK]
(+)-Alpha-Methylphenethylamine Sulphate (2:1)
DEXTROAMPHETAMINE SULFATE COMPONENT OF DELCOBESE
Q27122300
(+)-.ALPHA.-METHYLPHENETHYLAMINE SULFATE (2:1)
(+)-.ALPHA.-METHYLPHENETHYLAMINE SULPHATE (2:1)
Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1)
d-Amphetamine.sulfate, 1mg/ml in Methanol (as free base)
BENZENEETHANAMINE, alpha-METHYL-, (S)-, SULPHATE (2:1)
BENZENEETHANAMINE, .ALPHA.-METHYL-, (S)-, SULPHATE (2:1)
200-111-6
Dextroamphetamine sulfate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 368.49 ((C9H13N)2 ?? H2SO4)