Adenosine monophosphate | Solubility of Things

Identification

Molecular formula

C₁₀H₁₄N₅O₇P

CAS number

61-19-8

IUPAC name

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

State

At room temperature, AMP is typically found in a solid crystalline form.

Melting point (Celsius)

178.00

Melting point (Kelvin)

451.00

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

347.22g/mol

Molar mass

347.2210g/mol

Density

2.3000g/cm³

Appearence

Adenosine monophosphate (AMP) often appears as a white crystalline powder. It is generally odorless and has a slightly sweet taste. In aqueous solution, it is clear and colorless, showing good solubility in water.

Comment on solubility

Solubility of [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

The solubility of the compound C₁₀H₁₄N₅O₇P can be understood through several key factors:

Polarity: Due to the presence of multiple functional groups such as hydroxyl (–OH) and phosphonate (–PO₃H₂), the compound is likely to exhibit considerable polarity. This tends to enhance solubility in polar solvents like water.
Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding with water molecules, facilitating solvation and increasing solubility.
Ionization Potential: The phosphonic acid moiety may ionize in aqueous solutions, forming negatively charged species which can further interact favorably with solvent molecules.

In general, one might say:

“Compounds enriched with hydroxyl and phosphonate groups are often soluble in aqueous media due to their ability to readily interact with solvents.”

However, it is important to note that solubility could be influenced by factors such as:

pH of the solution
Temperature
Presence of other ions or solutes

Future studies may provide specific solubility values in various solvents, expanding our understanding of the behavior of this intriguing compound.

Interesting facts

Fascinating Insights into [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate is a compound that showcases the intricate relationship between organic chemistry and biological systems. Its structure highlights the role of nucleobase analogs in the context of biochemical processes.

Key Features:

Nucleic Acid Connection: This compound is closely related to pyrimidine and purine nucleotides, serving as a potential substrate or inhibitor in various enzymatic reactions.
Phosphate Group: The inclusion of a phosphonate group hints at its possible role in energy metabolism and signal transduction pathways.
Structure Specificity: The chirality present in its tetrahydrofuran ring suggests that specific stereochemistry can influence its biological activity and receptor interaction.

This compound is a type of nucleoside analog, which can mimic natural nucleotides. These analogs play crucial roles in the development of antiviral and anticancer therapies by disrupting cellular processes. Understanding how such structures interact within biological systems is paramount for drug design and discovery.

A Little History:

Research into nucleoside analogs has led to significant advancements in medical chemistry. As noted by one prominent biochemist, "The manipulation of nucleosides has revolutionized therapeutic approaches." This compound, with its complex functionality, is a prime example of how small changes in molecular structure can lead to profound biological consequences.

In summary, this compound not only represents a unique molecular architecture but also opens doors to exploring therapeutic interventions in various diseases through the lens of chemical and biological research. The study of such compounds is integral to advancing our understanding of life at the molecular level.

Synonyms

Adenosine 5'-diphosphate

Adenosine diphosphate

58-64-0

adenosine-5'-diphosphate

ADP

Adenosine 5'-(trihydrogen diphosphate)

5'-Adp

adenosine pyrophosphate

adenosine 5'-pyrophosphate

ADP (nucleotide)

5'-Adenylphosphoric acid

Adenosindiphosphorsaeure

Adenosine 5'-pyrophosphoric acid

Adenosine-5'-diphosphat

Adenosine 5'-diphosphoric acid

Adenosine diphosphoric acid

Ado-5'-P-P

H3adp

110123-09-6

BRN 0067722

CHEBI:16761

adenosine 5' diphosphate

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate

MFCD00066473

ADENOSINE, 5'-(TRIHYDROGEN PYROPHOSPHATE)

20398-34-9

61D2G4IYVH

adenosine-5-diphosphate

CHEMBL14830

1,4-Cyclohexadiene-3,3,6,6-d4

Dynorphin A (1-13), ala(2)-trp(4)-

((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate

104746-05-6

11062-03-6

112360-08-4

17791-27-4

4-(3-Carboxytrimethyleneoxy)-4/'/'-octylazobenzene

Adenosine disphosphate

[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

Adenosine diphosphate;ADP

C10H15N5O10P2

EINECS 200-392-5

UNII-61D2G4IYVH

1amw

1lkx

1ucn

1xxi

1yrs

2bfr

5'-ADP; ADP; Adenosine 5'-Diphosphoric Acid; Adenosine 5'-Pyrophosphate; Adenosine 5'-Pyrophosphoric Acid;

a-ADP

1ao0

1e8h

1hi5

1o0h

1oz4

1t3t

1y8o

Adenosine5'-diphosphate

ADP.H2

bmse000004

bmse000935

bmse000991

Epitope ID:137351

adenosine 5 inverted exclamation marka-diphosphate

Adenosine Diphosphate (ADP)

SCHEMBL24103

Adenosine diphosphate (6CI)

4-26-00-03629 (Beilstein Handbook Reference)

GTPL1712

SCHEMBL18076199

Adenosine 5'-Diphosphate-13C5

BDBM31995

DTXSID60883210

1m74

2c02

ADENOSINE DIPHOSPHATE [MI]

HY-W010918R

Adenosine 5'-diphosphate (Standard)

Adenosine-5'-Diphosphate, free acid

BDBM50368125

PDSP1_001088

PDSP2_001072

s9368

ADENOSINE DIPHOSPHATE [WHO-DD]

AKOS022179933

Adenosine-5'-(trihydrogen diphosphate)

CCG-268971

CS-W011634

HY-W010918

NA10698

NA63511

s10970

Adenosine, 5'-(trihydrogen diphosphate)

NCGC00163322-01

AC-32145

AS-11755

BP-58727

DB-022410

Adenosine 5'-diphosphate, >=95% (HPLC)

NS00014781

Adenosine diphosphate;Adenosine 5'-diphosphate

Adenosine 5'-(trihydrogen diphosphate) (9CI)

C00008

Adenosine 5'-(trihydrogen pyrophosphate) (8CI)

EN300-1588520

Q185253

9-{5-O-[hydroxy(phosphonooxy)phosphoryl]-b-D-glycero-pentofuranosyl}-9H-purin-6-amine

9H-Purin-6-amine, 9-[5-O-[hydroxy(phosphonooxy)phosphinyl]-.beta.-D-ribofuranosyl]-

9H-purin-6-amine, 9-[5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-D-glycero-pentofuranosyl]-

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate