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Barbituric acid

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Identification
Molecular formula
C4H4N2O3
CAS number
67-52-7
IUPAC name
2,6-dioxohexahydropyrimidine-4-carboxylic acid
State
State

At room temperature, barbituric acid is a solid. It comes as a crystalline powder, which is white to slightly yellow in color. This solid state is typical of many organic acids.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.15
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
128.09g/mol
Molar mass
128.0940g/mol
Density
1.5632g/cm3
Appearence

Barbituric acid appears as a white to slightly yellow crystalline powder. It is quite stable under normal conditions but should be stored away from moisture and light to prevent degradation. The compound is relatively soluble in water, and its crystalline form allows for distinct morphological identification.

Comment on solubility

Solubility of 2,6-Dioxohexahydropyrimidine-4-carboxylic Acid

The compound 2,6-dioxohexahydropyrimidine-4-carboxylic acid, with the chemical formula C4H4N2O3, exhibits intriguing solubility characteristics. Understanding its solubility behavior is essential for various applications in chemical processes and pharmaceutical formulations.

Key Solubility Features:

  • Polarity: The presence of carboxylic acid functional groups generally increases polarity, leading to enhanced solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of 2,6-dioxohexahydropyrimidine-4-carboxylic acid to form hydrogen bonds with water molecules contributes significantly to its solubility.
  • Temperature Dependency: Like many organic compounds, its solubility could vary with temperature. Increased temperatures might lead to higher solubility.

"Solubility is a crucial factor influencing reactivity and bioavailability." In the case of this compound:

  • It is expected to be soluble in basic aqueous solutions due to the deprotonation of the carboxylic acid group.
  • In contrast, solubility may be limited in non-polar solvents, aligning with general trends observed in carboxylic acids.

Thus, the solubility of 2,6-dioxohexahydropyrimidine-4-carboxylic acid reflects the balancing act between its structural features and the solvent's interactions.

Interesting facts

Interesting Facts about 2,6-Dioxohexahydropyrimidine-4-carboxylic Acid

2,6-Dioxohexahydropyrimidine-4-carboxylic acid is a fascinating compound within the field of organic chemistry, notable not only for its structure but also for its potential applications. Here are some intriguing aspects:

  • Biological Significance: This compound belongs to a class of compounds known as pyrimidines, which are essential components of nucleic acids. Pyrimidines play a crucial role in the structure and function of DNA and RNA, making them vital for biological processes.
  • Synthetic Pathways: 2,6-Dioxohexahydropyrimidine-4-carboxylic acid can be synthesized through various methods, often involving the cyclization of specific precursors in the presence of heat or catalysts. This versatility in synthesis opens doors for further exploration in pharmaceuticals and biochemistry.
  • Pharmaceutical Potential: Compounds with the pyrimidine ring structure are often investigated for their therapeutic properties. Many derivatives exhibit anti-cancer, anti-viral, and anti-inflammatory activities, highlighting the importance of continued research on similar compounds.
  • Complex Chemistry: The presence of both keto and carboxylic acid functional groups in its structure allows for diverse chemical reactions, such as esterification or amide formation. This feature makes it a valuable intermediate in organic synthesis.
  • Interdisciplinary Relevance: This compound finds relevance across various scientific fields, including medicinal chemistry, materials science, and agricultural chemistry. Its study can lead to the development of novel compounds with enhanced properties.

As a student of chemistry, exploring compounds like 2,6-Dioxohexahydropyrimidine-4-carboxylic acid can provide deep insights into how organic compounds impact the world around us. As noted by chemists, "Understanding the intricacies of compound synthesis and reactivity is key to unlocking new scientific frontiers." This compound is a testament to how understanding molecular structure can lead to innovations in science and technology.

Synonyms
155-54-4
Dihydroorotic acid
hydroorotic acid
DL-Dihydroorotic acid
2,6-dioxohexahydropyrimidine-4-carboxylic acid
dihydroorotate
4,5-dihydroorotic acid
5,6-dihydroorotate
2,6-dioxo-1,3-diazinane-4-carboxylic acid
4-pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-
6202-10-4
39LRK7UX5B
CHEBI:30865
5,6-dihydro-orotic acid
HYDROOROTIC ACID [MI]
HYDROOROTIC ACID, DL-
5,6-DIHYDROOROTIC ACID
DL-4,5-DIHYDROOROTIC ACID
6-HYDROURACILCARBOXYLIC ACID
DL-Dihydoorotic Acid
4,5-dihydroorotate
5,6-DIHYDROURACIL-6-CARBOXYLIC ACID
Orotic acid, 4,5-dihydro-
UNII-39LRK7UX5B
L-hydroorotate
MFCD00085339
R,S-Hydroorotate
DL-hydroorotic acid
DL-dihydroortotic acid
(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
CHEMBL75782
SCHEMBL121953
DTXSID40861839
UFIVEPVSAGBUSI-UHFFFAOYSA-N
(+/-)-DIHYDROOROTIC ACID
AAA15554
BCP33011
HYDROOROTIC ACID, (+/-)-
AKOS006228089
HYDROOROTIC ACID DL-FORM [MI]
SB45071
SB56808
AS-18439
SY042036
DB-064092
CS-0046700
NS00096393
2,6-dioxo-hexahydro-pyrimidine-4-carboxylate
D72863
EN300-297330
(+)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate
(R)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate
(S)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate
EBA89F91-9BA4-4F53-A555-AACB4A7DF0FA
Q2823223
(+)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
(R)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
(S)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
622-692-9
993-292-2