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Triazolopyrimidine

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Identification
Molecular formula
C17H14Br2N4O3
CAS number
59729-32-7
IUPAC name
2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
State
State

At room temperature, this compound is a solid, typically manifesting as a pale to light brown powder. It is stable under standard conditions and should be kept in airtight containers to prevent hygroscopic absorption and oxidative degradation.

Melting point (Celsius)
267.00
Melting point (Kelvin)
540.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
500.12g/mol
Molar mass
500.0000g/mol
Density
1.7890g/cm3
Appearence

2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol appears as a light brown solid with a crystalline structure. It often comes in fine powder form or larger crystalline fragments, depending on its preparation methods.

Comment on solubility

Solubility of 2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (C17H14Br2N4O3)

The solubility characteristics of 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol can be described as moderate, influenced by its complex molecular structure and the presence of various functional groups.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar amino and phenolic groups typically enhances solubility in polar solvents, specifically in water to some extent.
  • Hydrophobic Interactions: The dibromo substitution introduces hydrophobic characteristics that may restrict solubility in highly polar solvents.
  • Solvent Choice: Solubility is generally better in organic solvents, such as DMSO and ethanol, compared to water.

As you explore its solubility, it's noteworthy that:

  • **pH Sensitivity:** The pH of the solvent can significantly impact the solubility, with different pH levels influencing the ionization of functional groups.
  • **Temperature Dependence:** Like many organic compounds, increased temperature often enhances solubility.

In conclusion, while 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol is expected to show moderate solubility across various solvents, careful selection of solvent and conditions is crucial for optimal results. Experimentation under varying conditions can yield valuable insights into its solubility behavior.

Interesting facts

Exploring 2,6-Dibromo-4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenol

2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol is a fascinating compound that showcases the intricate interplay between bromine, nitrogen, and aromatic systems. Here are some noteworthy aspects of this chemical:

  • Anticancer Potential: The structure of this compound, particularly the quinazoline moiety, has been associated with various biological activities including anticancer effects. Its potential as a therapeutic agent is an area of active research.
  • Versatile Chemistry: The presence of bromine atoms enhances the reactivity of the compound, providing pathways for further derivatization and synthetic exploration.
  • Role of Functional Groups: The dimethoxy groups and the amino functionalities contribute significantly to the compound's solubility and biological activity, potentially allowing for selective interactions within biological systems.
  • Structure-Activity Relationship (SAR): Researchers often study compounds like this to understand how modifications to the structure can influence their biological activity, which is crucial for drug design and development.

As a relevant example of how chemistry intersects with medicinal applications, 2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol embodies the potential of synthetic chemistry in developing new therapies. Its complexity and potential applications make it a compelling subject for further study and exploration.

Synonyms
WHI-P97
211555-05-4
2,6-dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
CHEMBL421942
Phenol, 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-
2,6-Dibromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol
2,6-Dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
HMS3265E23
SCHEMBL323445
WHI-P 97
WHI-P97?
CHEBI:91344
DTXSID20274408
HMS3265E24
HMS3265F23
HMS3265F24
BCP29062
EX-A3026
BDBM50326421
ZB1538
AKOS030526716
CS-0054
NCGC00346942-01
NCGC00346942-02
AC-36307
AS-70981
HY-11067
DB-364410
S5904
F82227
WHI-P97; WHIP 97; WHIP97; WHIP-97
BRD-K68407802-001-01-9
Q27163221
Z2216906878
2,6-dibromo-4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
2,6-Dibromo-4-(6,7-dimethoxy-quinazolin-4-ylamino)-phenol
4-(3',5'-dibromo-4-hydroxyphenyl)amino-6,7-dimethoxyquinazoline