Netilmicin | Solubility of Things

Identification

Molecular formula

C₂₁H₄₁N₅O₇

CAS number

56391-56-1

IUPAC name

2,6-diamino-N-[5-amino-1-[[1-[[2-[[2-[[1-[[2-[[1-[[2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]hexanamide

State

At room temperature, Netilmicin is in a solid state. It is usually handled in its sulfate salt form due to its application in pharmaceuticals, where it is dissolved in water for administration as an injection.

Melting point (Celsius)

275.50

Melting point (Kelvin)

548.65

Boiling point (Celsius)

237.50

Boiling point (Kelvin)

510.65

General information

Molecular weight

585.64g/mol

Molar mass

585.6360g/mol

Density

1.1700g/cm³

Appearence

Netilmicin typically appears as a white to off-white crystalline powder. It is often used in its sulfate form, which is also a white powder. The compound is soluble in water, which can be reflected in its use in injectable solutions for medical applications.

Comment on solubility

Solubility of 2,6-diamino-N-[5-amino-1-[[1-[[2-[[2-[[1-[[2-[[1-[[2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]hexanamide

The solubility of 2,6-diamino-N-[5-amino-1-[[1-[[2-[[2-[[1-[[2-[[1-[[2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]hexanamide (C₂₁H₄₁N₅O₇) is influenced by its complex structure, which features multiple functional groups.

In general, compounds with a high number of amino groups and hydroxymethyl substituents tend to present interesting solubility traits:

Amino Groups: The presence of multiple amino groups can increase interactions with polar solvents, enhancing solubility in water.

Hydroxymethyl Groups: Hydroxymethyl groups can also promote hydrogen bonding, further facilitating dissolution.

Complex Structure: The large and branched nature of this compound suggests a potential for both hydrophilic and hydrophobic regions, which may lead to unpredictable solubility behaviors.

It is anticipated that this compound may exhibit:

Moderate to high solubility in polar solvents such as water due to interactions from the amino and hydroxyl functionalities.

Lower solubility in non-polar solvents, as the bulky hydrophobic sections may hinder the compound's overall compatibility with such environments.

Ultimately, the precise solubility characteristics can vary widely based on factors such as temperature, pH, and the presence of other solutes. Testing under varying conditions is recommended to fully explore solubility profiles.

Interesting facts

Interesting Facts about 2,6-Diamino-N-[5-amino-1-[[1-[[2-[[2-[[1-[[2-[[1-[[2-amino-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]hexanamide

This compound is a highly intricate synthetic molecule that showcases the complexity achievable in organic chemistry. Here are some fascinating aspects:

Versatility: The numerous functional groups present in this compound make it a candidate for various applications, particularly in medicinal chemistry.

Structure: The lengthy and branched structure reflects the compound's potential for biological activity, particularly in drug design, where such compounds can modulate biological pathways effectively.

Similarities to Natural Compounds: The design seems to mimic aspects of naturally occurring peptides, suggesting that it may interact with biological systems in specific ways that are yet to be fully understood.

Research Potential: Due to its complex design, researchers are excited about its potential role in therapies, especially in areas such as cancer treatment and antimicrobial activity.

As we delve deeper into the realm of organic compounds, the synthesis and study of such polyfunctional molecules demonstrate how exciting and challenging the field of chemistry can be. Engaging with these compounds allows chemists to explore new frontiers in drug development, potentially leading to groundbreaking therapies in the future.

Synonyms

119386-39-9

H-LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser amide

2,6-diamino-N-[6-amino-1-[[1-[[1-[[1-[[1-[[1-[[1-[(1-amino-3-hydroxy-1-oxopropan-2-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]hexanamide

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-NH2

DTXSID70274413

UEA38639

DA-75220