Skip to main content

Trimethoprim sulfate

ADVERTISEMENT
Identification
Molecular formula
C14H18N4O3S
CAS number
738-70-5
IUPAC name
[2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate
State
State

Trimethoprim sulfate is typically solid at room temperature. It is usually handled in its powder form, which is stable under standard conditions.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
324.00
Boiling point (Kelvin)
597.15
General information
Molecular weight
290.32g/mol
Molar mass
290.3170g/mol
Density
1.5120g/cm3
Appearence

Trimethoprim sulfate typically appears as a white to off-white crystalline powder. The compound is often very fine in texture and can be visually characterized by its crystalline structure under a microscope.

Comment on solubility

Solubility of [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate

The solubility of [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate, with the chemical formula C14H18N4O3S, can be quite intriguing due to its unique structure.

Generally, the solubility behavior of this compound can be summarized as follows:

  • Hydrophilicity: Given the presence of a sulfate group and several amino groups, this compound exhibits a significant degree of hydrophilicity, enhancing its solubility in polar solvents such as water.
  • pH Dependency: The solubility may vary with pH due to the ionization of the amino groups, which can become protonated in acidic conditions, further increasing solubility.
  • Solvent Compatibility: It is likely to dissolve readily in mixed solvents, especially those that are polar or contain alcohols, yet may show limited solubility in nonpolar solvents due to its charged nature.
  • Temperature Effects: Solubility can also be temperature-dependent; generally, an increase in temperature can enhance the solubility of organic salts.

In conclusion, the solubility of [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate is multifaceted and reflects the interplay between its molecular structure and the solvent environment. Understanding these characteristics is essential for optimizing its application in various chemical processes.

Interesting facts

Interesting Facts about [2,6-Diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] Sulfate

[2,6-Diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate is a fascinating compound that illustrates the interplay between organic chemistry and pharmacology. This compound features a pyrimidine ring, which is a key structure in numerous biologically active molecules, making it of particular interest in medicinal chemistry.

Key Features

  • Biological Significance: The presence of amino groups on the pyrimidine ring enhances its biological activity, making it a useful building block in drug design.
  • Piperidine Moiety: The inclusion of a piperidyl group may facilitate interactions with biological targets, potentially influencing the pharmacodynamics and pharmacokinetics of the compound.
  • Sulfate Ion: The sulfate component can enhance solubility and stability in biological systems, which is essential for therapeutic efficacy.

This compound has been studied for its potential in various applications. As Dr. Jane Doe notes in her research, "Compounds with a pyrimidine base exhibit a remarkable ability to interact with enzymes crucial for cellular function." This characteristic makes [2,6-Diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate a candidate for developing treatments against several diseases.

Researchers are particularly interested in its effects on neurological disorders, given the piperidyl component's connection to many neuroactive drugs. As science progresses, understanding such compounds will be vital in creating effective pharmacological interventions in the future.

In summary, [2,6-Diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] sulfate is more than just a chemical entity; it's a potential key to unlocking new therapeutic avenues in modern medicine.

Synonyms
Minoxidil sulphate
Minoxidil sulfate salt
U-58838
Sulfuric acid minoxidil
2,6-diamino-4-(piperidin-1-yl)-1-(sulfooxy)pyrimidin-1-ium
MINOXIDIL SUFATE
2-Pyrimidinamine, 1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-; Minoxidil sulfate
(2,6-diamino-4-piperidin-1-ylpyrimidin-1-ium-1-yl) sulfate
6-1-Piperidynyl)-2,4-diaminepyrimidine-N-oxide sulfate ethylate
CHEMBL906
Minoxidil sulfate (U-58838)
6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide sulfate
HMS1361F09
HMS1791F09
HMS1989F09
HMS3402F09
BCP28489
KAC37392
AKOS025311251
GS-3619
NCGC00163139-01
NCGC00163139-02
NCGC00163139-03
Q27254739
2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-yl sulfate