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Sufentanil

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Identification
Molecular formula
C28H35F6N3O5
CAS number
56030-54-7
IUPAC name
[2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium
State
State

Sufentanil is generally handled in a solid state under controlled conditions due to its potency.

Melting point (Celsius)
129.00
Melting point (Kelvin)
402.15
Boiling point (Celsius)
515.77
Boiling point (Kelvin)
788.92
General information
Molecular weight
578.67g/mol
Molar mass
578.6670g/mol
Density
1.7609g/cm3
Appearence

Sufentanil is a white to off-white powder. It is practically insoluble in water, soluble in methanol and in acetone, and sparingly soluble in alcohol.

Comment on solubility

Solubility of [2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium (C28H35F6N3O5)

The solubility of [2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium in various solvents can greatly impact its applications and usability in different chemical environments. This compound, characterized by its complex structure, displays solubility characteristics influenced by several factors:

  • Polarity: Given the presence of numerous oxygen atoms and fluorinated groups, this compound is likely to exhibit differential solubility in polar vs. non-polar solvents. It may be more soluble in polar solvents such as water or methanol due to hydrogen bonding.
  • Hydrogen bonding: The amine group present in the compound may facilitate stronger interactions with solvents capable of hydrogen bonding. This can enhance solubility in solvents like ethanol or dimethyl sulfoxide (DMSO).
  • Temperature: As with many compounds, an increase in temperature typically enhances solubility, allowing the compound to dissolve more effectively in various solvents.
  • pH levels: The solubility of ammonium compounds can also depend significantly on the pH of the solution, with acidic or basic environments affecting the ionization state of the molecule.

In summary, the solubility of [2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium is dictated by its unique chemical structure and environmental conditions. Understanding these factors is pivotal for its effective application in pharmacological and chemical synthesis contexts.

Interesting facts

Interesting Facts about [2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium

This complex synthetic compound, with its intriguing structure, is a prime example of how chemical modifications can enhance molecular properties. Here are some captivating aspects of this compound:

  • Structure and Function: The compound consists of a benzoyl moiety substituted with two trifluoroethoxy groups. This unique configuration significantly alters its reactivity and interactions, making it a potential candidate for various applications in material science and pharmaceuticals.
  • Fluorine’s Influence: The presence of fluorine atoms contributes to increased lipophilicity and may enhance the compound’s permeability across biological membranes. This characteristic is essential for drug design, optimizing the pharmacokinetics of therapeutic agents.
  • Piperidine Enhancement: The inclusion of a piperidylmethyl group can impart unique biological properties, potentially influencing receptor interactions in medicinal chemistry. Piperdines are well-known for their capability to modulate neurotransmitter systems.
  • Versatility: Compounds like this facilitate the exploration of structure-activity relationships in medicinal chemistry, allowing researchers to develop targeted therapeutics tailored to specific biological pathways.

As chemists continue to push the boundaries of compound synthesis, derivative compounds such as [2,5-bis(2,2,2-trifluoroethoxy)benzoyl]-(2-piperidylmethyl)ammonium represent a fascinating blend of structural ingenuity and functional application. Exploring this compound not only aids in understanding complex chemical interactions but also inspires innovative research in drug discovery and materials innovation.