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Dichlorodiphenylacetic acid

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Identification
Molecular formula
C14H10Cl2O2
CAS number
83-07-8
IUPAC name
2,2-bis(4-chlorophenyl)acetic acid
State
State

At room temperature, Dichlorodiphenylacetic acid is typically found as a solid. It is stable under standard conditions and does not readily decompose.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
348.00
Boiling point (Kelvin)
621.15
General information
Molecular weight
281.14g/mol
Molar mass
281.1350g/mol
Density
1.2200g/cm3
Appearence

Dichlorodiphenylacetic acid appears as a white crystalline solid. Its powdered form is similarly white and it is often odorless, though some samples have been noted to have a faint organic smell.

Comment on solubility

Solubility of 2,2-bis(4-chlorophenyl)acetic acid

2,2-bis(4-chlorophenyl)acetic acid, with its complex structure, presents interesting solubility characteristics that are worth noting. This compound primarily exhibits limited solubility in water due to its large hydrophobic aromatic groups, which hinder its interaction with polar water molecules.

Key Points on Solubility:

  • Water Solubility: Generally low, making it difficult for this compound to dissolve in aqueous solutions.
  • Organic Solvents: It tends to be more soluble in organic solvents such as ethanol, methanol, and acetone, where non-polar interactions are more favorable.
  • Temperature Influence: Increased temperature may enhance its solubility in organic solvents, as higher kinetic energy helps to overcome solute-solvent interactions.

As a rule of thumb, the greater the hydrophobic character of a molecule, the lesser its solubility in polar solvents like water. This principle holds true for 2,2-bis(4-chlorophenyl)acetic acid, where its bulky aromatic chlorinated phenyl groups significantly contribute to its solubility profile. Understanding these solubility conditions is essential for practical applications in chemical formulations and drug design.

Interesting facts

Interesting Facts about 2,2-bis(4-chlorophenyl)acetic acid

2,2-bis(4-chlorophenyl)acetic acid, often referred to in the scientific community as a notable compound due to its structural intricacies and applications. This compound is particularly interesting for various reasons:

  • Pharmaceutical Relevance: It belongs to a class of compounds that have been extensively studied for their potential pharmacological effects, including anti-inflammatory and analgesic properties.
  • Structural Complexity: The compound consists of two 4-chlorophenyl groups attached to a central acetic acid moiety. This unique structure contributes to its biological activity and interaction with biological targets.
  • Ecotoxicological Studies: Research has indicated that compounds with similar chlorinated phenyl structures could have significant environmental impacts, leading scientists to explore their degradation pathways and ecological effects.
  • Combinatorial Chemistry: Its structure allows it to serve as a versatile building block in combinatorial synthesis, enabling the development of new therapeutic agents.
  • Regulatory Implications: As a chlorinated compound, it raises questions regarding environmental regulations and safety assessments due to potential persistence in the environment.

In summary, 2,2-bis(4-chlorophenyl)acetic acid serves as a pivotal compound in the field of chemistry, bridging gaps between organic synthesis, pharmacology, and environmental science. With ongoing research, the potential implications of this compound continue to unfold.

Synonyms
Bis(4-chlorophenyl)acetic acid
2,2-Bis(4-chlorophenyl)acetic acid
83-05-6
p,p'-DDA
BIS(P-CHLOROPHENYL)ACETIC ACID
Dichlorodiphenylacetic acid
p,p'-Dichlorodiphenylacetic acid
Di(p-chlorophenyl)acetic acid
2,2-Bis(p-chlorophenyl)acetic acid
Bis(p-chlorphenyl)essigsaeure
Acetic acid, bis(p-chlorophenyl)-
NSC 4279
EINECS 201-451-8
UNII-N0U8S29G6E
BRN 1913593
N0U8S29G6E
DTXSID3040699
CHEBI:28139
AI3-07573
4,4'-DDA
NSC-4279
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-
Benzeneacetic acid, 4-chloro-.alpha.-(4-chlorophenyl)-
DDA, P,P'-
DTXCID1020699
Acetic acid, bis-(4-chlorophenyl)
Bis(4'-chlorophenyl)acetate
4-Chloro-alpha-(4-chlorophenyl)benzeneacetic acid
Bis(p-chlorphenyl)essigsaeure [German]
Maybridge1_006953
WLN: QYVR DG&R DG
Oprea1_249828
SCHEMBL467546
bis(4-chlorophenyl) acetic acid
CHEMBL1879491
HMS561E01
NSC4279
2,2-Bis(4-chlorophenyl)aceticacid
Bis-(4-chloro-phenyl)-acetic acid
Tox21_301432
BBL034637
CCG-45383
GEO-02561
MFCD00004248
STL415948
2,2-bis(4-chlorophenyl)-acetic acid
AKOS001584787
Bis(4-chlorophenyl)acetic acid, 98%
CAS-83-05-6
2,2-bis-(4-chloro-phenyl)-acetic acid
NCGC00164026-01
NCGC00164026-02
NCGC00255690-01
AS-62049
FB124020
CS-0134772
NS00005027
4,4'-DDA, PESTANAL(R), analytical standard
C06640
G72323
AB01331060-02
SR-01000389220
SR-01000389220-1
SR-01000389220-2
Q27103524
4-CHLORO-.ALPHA.-(4-CHLOROPHENYL)BENZENEACETIC ACID