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Bupropion

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Identification
Molecular formula
C13H18ClNO
CAS number
34911-55-2
IUPAC name
2-(tert-butylamino)-1-(2-chlorophenyl)ethanol
State
State

At room temperature, this compound is typically in a solid state. It is usually supplied as a crystalline powder.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
344.53
Boiling point (Kelvin)
617.68
General information
Molecular weight
239.74g/mol
Molar mass
239.7600g/mol
Density
1.1943g/cm3
Appearence

This compound typically appears as a white solid crystalline powder. It may also be described as off-white or slightly yellowish. The appearance can vary slightly depending on the specific form and purity of the sample.

Comment on solubility

Solubility of 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol

The solubility of 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol (C13H18ClNO) is influenced by several factors, primarily its molecular structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of the hydroxyl group (-OH) typically suggests that this compound has the potential to engage in hydrogen bonding, which may enhance its solubility in polar solvents, such as water.
  • Hydrophobic Interactions: The tert-butyl group contributes a non-polar character, which may limit solubility in polar solvents while enhancing solubility in non-polar solvents.
  • Influence of Chlorine Atom: The 2-chlorophenyl moiety adds both steric bulk and a degree of electronegativity, which can affect the compound's interaction with solvents.

Considering these factors, the solubility of this compound is likely to be:

  1. Relatively soluble in polar organic solvents due to the presence of the hydroxyl group.
  2. Less soluble in water, given the competing influences of the hydrophobic tert-butyl group.
  3. Potentially soluble in aprotic solvents where the polar interactions of the hydroxyl group can still be effective without too much competition from the non-polar portions.

In conclusion, while the specific solubility values can only be accurately determined through experimentation, understanding the structural features provides valuable insights into the solubility behavior of this compound.

Interesting facts

Interesting Facts about 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol

2-(tert-butylamino)-1-(2-chlorophenyl)ethanol is a fascinating compound that has garnered attention in the fields of medicinal chemistry and pharmacology. Here are some noteworthy aspects of this compound:

  • Pharmacological Potential: This compound is often investigated for its potential as a therapeutic agent. Its structure suggests properties that may be useful in treating various medical conditions.
  • Chlorophenyl Influence: The presence of the 2-chlorophenyl group can significantly influence the compound's biological activity, making it an object of study for researchers aiming to design better pharmaceuticals.
  • Basic Amino Group: The tert-butylamino moiety enhances the compound's ability to interact with biological systems. Amino groups are crucial in forming hydrogen bonds, which often contribute to molecular recognition in biochemical processes.
  • Structure-Activity Relationship (SAR): This compound can be valuable in studying SAR, where scientists explore how changes in structure affect a compound's activity. It allows for the design of derivatives that may exhibit enhanced properties.
  • Research Relevance: Ongoing research may dive into the compound's potential anti-inflammatory or analgesic properties, making it an interesting subject for those exploring non-steroidal options in pain management.

As quoted by many researchers, "The right chemical structure can make all the difference in drug efficacy and selectivity." The unique combination of a tert-butyl group and a chlorophenyl moiety in this compound exemplifies how structural modifications can lead to significant enhancements in biological performance.

This compound remains a captivating subject in the chemistry and pharmacology landscape, providing numerous possibilities for future research and application.

Synonyms
tulobuterol
41570-61-0
2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol
Tulobuterolum
Tulobuterolum [INN-Latin]
Tulobuterol [INN:BAN:JAN]
Atenos
2-Chloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol
2-tert-Butylamino-1-(2-chlorphenyl)ethanol
591I9SU0F7
C-78 (free base)
TULOBUTEROL [MI]
TULOBUTEROL [INN]
TULOBUTEROL [JAN]
NSC-758643
TULOBUTEROL [WHO-DD]
alpha-((tert-Butylamino)methyl)-o-chlorobenzyl alcohol
1-(2-chlorophenyl)-2-[[1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl]amino]ethanol
DTXSID7048457
2-(tert-butylamino)-1-(2-chlorophenyl)ethan-1-ol
NSC 758643
Atenos (TN)
Tulobuterolum (INN-Latin)
(+/-)-Tulobuterol
.ALPHA.-((TERT-BUTYLAMINO)METHYL)-O-CHLOROBENZYL ALCOHOL
2-Chloro-alpha-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
.alpha.-[(tert-Butylamino)methyl]-o-chlorobenzyl alcohol
UNII-591I9SU0F7
1-(o-chlorophenyl)-2-tert-butylaminoethanol
HN 078
1246820-75-6
Spectrum_001648
Spectrum2_001616
Spectrum3_001900
Spectrum4_000206
Spectrum5_001285
Tulobuterol (JP17/INN)
Lopac0_001149
BSPBio_003440
KBioGR_000811
KBioSS_002128
DivK1c_000712
SCHEMBL122692
SPBio_001651
CHEMBL1159717
DTXCID7028431
CHEBI:93856
KBio1_000712
KBio2_002128
KBio2_004696
KBio2_007264
KBio3_002943
R03AC11
R03CC11
NINDS_000712
HMS2090E11
HMS3715J21
HY-B1810
BDBM50421717
AKOS010122688
CCG-205223
DB12248
SDCCGSBI-0051116.P004
IDI1_000712
NCGC00016034-02
NCGC00016034-03
NCGC00016034-09
NCGC00162354-01
AS-10998
CID 49849891
SBI-0051116.P003
DB-050772
Tulobuterol 1000 microg/mL in Acetonitrile
CS-0013856
NS00002191
VU0244437-2
D02151
EN300-718088
F17342
AB00053692-02
AB00053692_03
2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol #
L013403
Q909353
SR-01000076165-4
BRD-A37441042-003-02-2
BRD-A37441042-003-04-8
2-Chloro-.alpha.-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol