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α-Ketoglutaric acid

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Identification
Molecular formula
C5H6O5
CAS number
328-50-7
IUPAC name
2-oxopentanedioic acid
State
State

At room temperature, α-Ketoglutaric acid is in a solid state. It is often marketed in its crystalline form for ease of handling in laboratory and industrial applications.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
146.11g/mol
Molar mass
146.1120g/mol
Density
1.5230g/cm3
Appearence

α-Ketoglutaric acid appears as a white crystalline solid. It is often odorless or possesses a slight acidic smell. The crystals are typically cubic in shape and are highly soluble in water, reflecting its hydrophilic nature. When dissolved, it provides a slightly acidic solution.

Comment on solubility

Solubility of 2-Oxopentanedioic Acid (C5H6O5)

2-Oxopentanedioic acid, commonly known as medlar acid, is an intriguing compound in terms of its solubility characteristics. Its solubility can be summarized as follows:

  • Solubility in Water: This compound is soluble in water due to its polar carboxylic acid functional groups, which facilitate interaction with water molecules.
  • Organic Solvents: 2-Oxopentanedioic acid exhibits variable solubility in organic solvents. It is generally less soluble in non-polar solvents compared to polar ones, aligning with the principle of "like dissolves like."
  • pH Dependence: The solubility can be influenced by the pH of the solution. At higher pH levels, the carboxylic acid groups can deprotonate, enhancing solubility in aqueous environments.

In conclusion, the solubility of 2-oxopentanedioic acid in different solvents underscores the significance of molecular structure and interactions. Its ability to dissolve in polar solvents showcases its chemical nature, making it a compound of interest for various applications.

Interesting facts

Interesting Facts About 2-Oxopentanedioic Acid

2-Oxopentanedioic acid, commonly known as oxaloacetic acid, is a fascinating compound that plays a crucial role in various biological processes. Here are some intriguing aspects of this compound:

  • Cyclic Metabolism: This compound is a key intermediate in the citric acid cycle (Krebs cycle), which is essential for cellular respiration in all aerobic organisms. Its presence helps facilitate the conversion of carbohydrates, fats, and proteins into energy.
  • Precursor to Amino Acids: 2-oxopentanedioic acid serves as a precursor for the synthesis of important amino acids, such as aspartate and asparagine, highlighting its importance in the metabolic pathways of living organisms.
  • Role in Plant Metabolism: The compound is also involved in the metabolism of plants, assisting in the synthesis of specific compounds that are significant for growth and development.
  • Clinical Implications: Due to its involvement in various metabolic pathways, studying 2-oxopentanedioic acid can provide insights into certain metabolic disorders and how they may be treated or managed.
  • Research Applications: This compound is often utilized in biochemical research to understand metabolic functions better and to develop pharmaceuticals targeting metabolic pathways.

In summary, 2-oxopentanedioic acid is not just a simple organic compound; it is a vital player in the complex web of biological processes that sustain life. Its contributions to metabolism and potential implications in health and disease make it an exhilarating topic of study for chemists and biologists alike. As we continue to explore its functions, the insights gained could be pivotal in advancing our understanding of metabolism and therapeutic strategies.

Synonyms
2-ketoglutaric acid
2-Oxopentanedioic acid
328-50-7
2-oxoglutaric acid
alpha-ketoglutaric acid
alpha-ketoglutarate
2-oxoglutarate
Oxoglutaric acid
a-ketoglutaric acid
Oxoglutarate
oxogluric acid
2-Oxo-1,5-pentanedioic acid
Pentanedioic acid, 2-oxo-
alpha Ketoglutarate
Glutaric acid, 2-oxo-
Alphaketoglutaric acid
alpha-Oxoglutaric acid
Oxoglurate
Glutaric acid, alpha keto
2-ketoglutarate
2-Oxo-Glutaric Acid
ketoglutaric acid
Pentanedioic acid, oxo-
Bis(L-arginin)-2-oxoglutarat
.alpha.-Ketoglutaric acid
Oxoglurate [INN]
MFCD00004165
AI3-26938
378-50-7
NSC 17391
NSC-17391
alpha-Ketoglutaric acid alpha
DTXSID5033179
CHEBI:30915
8ID597Z82X
2-oxo-pentanedioic acid
alpha-keto-Glutaric acid
NSC17391
.alpha.-Oxoglutaric acid
17091-15-5
CHEMBL1686
ALFA-KETOGLUTARIC ACID
A-KETOGLUTARICUM ACIDUM
OXOGLURIC ACID [MART.]
34410-46-3
DTXCID3013179
OXOGLURIC ACID [WHO-DD]
Glutaric acid, 2-oxo- (8CI)
2-OXOPENTANEDIOIC ACID [FHFI]
A-KETOGLUTARICUM ACIDUM [HPUS]
alphaketoglutarate
.ALPHA.-KETOGLUTARIC ACID [MI]
2-oxopentanedionate
2-Ketoglutaricacid
Pentanedioic acid, 2-oxo-, sodium salt
OXOGLURIC ACID (MART.)
alpha ketoglutaric acid
AKG
CAS-328-50-7
2-oxo-pentanedioicaci
EINECS 206-330-3
alpha-Ketoglutaricum acidum
UNII-8ID597Z82X
2oxoglutaric acid
3ouj
4nro
4oct
4qkd
4usi
keto glutaric acid
2-oxoglutaric-acid
alphaOxoglutaric acid
2oxopentanedioic acid
Glutaric acid, 2oxo
.alpha.-ketoglutarate
alpha-oxo-glutaric acid
alpha -ketoglutaric acid
Pentanedioic acid, 2oxo
alphaKetoglutaricum acidum
hydron;2-oxopentanedioate
alpha-Oxopentanedioic acid
2Oxo1,5pentanedioic acid
2-Oxo-1,5-pentanedioate
bmse000064
bmse000801
bmse000937
SCHEMBL7400
NCIStruc1_001710
NCIStruc2_000215
Glutaric acid, 2oxo (8CI)
Glutaric acid, .alpha.-keto-
Glutaric acid, 2-oxo-(8CI)
GTPL3636
2-Ketoglutaric acid (standard)
KETOGLUTARIC ACID [INCI]
HY-W013636R
NCI17391
Pentanedioic acid, 2-oxo- (9CI)
Tox21_110016
Tox21_200918
BBL010614
BDBM50303766
CCG-37641
NCGC00013225
s6237
STK002174
AKOS000120908
CS-W014352
DB02926
DB03806
DB08845
FK09820
HY-W013636
NCGC00013225-01
NCGC00013225-02
NCGC00013225-03
NCGC00013225-04
NCGC00013225-05
NCGC00013225-06
NCGC00090946-01
NCGC00090946-02
NCGC00258472-01
alpha-Ketoglutaric acid, >=99.0% (T)
AS-12579
NCI60_001411
SY004310
2-Oxopentanedioic acid;2-Oxoglutaric acid
DB-048280
K0005
NS00013803
EN300-18049
C00026
D70548
SBI-0053864.0002
AB00640269-03
Q306140
alpha-Ketoglutaric acid, >=98.5% (NaOH, titration)
BRD-K89712525-001-02-1
Z57127547
F2191-0182
15118487-024F-412C-9995-24E8E6CA72EF
206-330-3
alpha-Ketoglutaric acid, BioReagent, suitable for cell culture, suitable for insect cell culture