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α-Ketoglutaric acid

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Identification
Molecular formula
C5H6O5
CAS number
328-50-7
IUPAC name
2-oxohexanedioic acid
State
State

At room temperature, α-Ketoglutaric acid is typically found in a solid state. Being a crystalline substance, it maintains its structure as a solid but may dissolve in water under specific conditions.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
273.15
General information
Molecular weight
146.11g/mol
Molar mass
146.1110g/mol
Density
1.6520g/cm3
Appearence

α-Ketoglutaric acid is a white crystalline solid. It is typically odorless and may appear as a powder with a tendency to form clumps.

Comment on solubility

Solubility of 2-oxohexanedioic acid (C5H6O5)

2-oxohexanedioic acid, commonly known as adipic acid, presents interesting solubility characteristics due to its molecular structure. Understanding its solubility can greatly assist in applications within various chemical processes and industries.

Solubility Behavior

This compound displays the following solubility phenomena:

  • Water Solubility: 2-oxohexanedioic acid is moderately soluble in water. Its carboxylic acid groups allow for hydrogen bonding, which enhances its interaction with water molecules.
  • Solvents: It is also soluble in various organic solvents, including alcohols and ethers, owing to its polar functional groups.
  • Temperature Effect: Like many organic acids, its solubility tends to increase with temperature, which is a common trend attributed to increased molecular motion and disruption of solute-solvent interactions.

Key Influencing Factors

The solubility of 2-oxohexanedioic acid can be influenced by:

  1. pH Levels: The degree of ionization of the carboxylic groups is affected by pH, impacting overall solubility in water.
  2. Concentration: At higher concentrations, the solubility can decrease due to saturation, leading to precipitation.
  3. Presence of Salts: The common ion effect can also play a role, where the presence of salts in solution reduces the solubility of acids in certain conditions.

Overall, the solubility of 2-oxohexanedioic acid in various media emphasizes its chemical versatility, making it an important compound in both synthetic and industrial applications.

Interesting facts

Interesting Facts About 2-Oxohexanedioic Acid

2-Oxohexanedioic acid, also known as α-ketoadipic acid, is a fascinating compound with notable implications in both organic chemistry and biochemistry. Here are some captivating insights about this compound:

  • Biochemical Significance: 2-oxohexanedioic acid has a vital role in metabolic pathways. It is part of the citric acid cycle and is produced during the metabolism of certain amino acids.
  • Synthesis: The compound can be synthesized from adipic acid through a series of chemical reactions. This process demonstrates the transformation of simpler molecules into more complex structures.
  • Application in Research: It is utilized in various research studies, particularly in the investigation of metabolic disorders and enzyme functionality. Scientists study how its presence affects enzymatic reactions.
  • In the Laboratory: 2-oxohexanedioic acid can serve as an intermediate in the synthesis of other compounds, making it pivotal in pharmaceutical chemistry.
  • Potential Health Impact: Some studies suggest that abnormal levels of 2-oxohexanedioic acid might be associated with metabolic diseases, underlining its importance in medical research.

As a compound that bridges the fields of chemistry and biology, 2-oxohexanedioic acid exemplifies how even small molecules can have profound effects across various scientific disciplines. Its intriguing properties continue to inspire researchers and chemists alike.

Synonyms
2-Oxoadipic acid
2-Oxohexanedioic acid
3184-35-8
Oxoadipic acid
alpha-Ketoadipic acid
2-oxoadipate
2-Ketoadipic acid
Hexanedioic acid, 2-oxo-
2-Oxo-hexanedioic acid
Oxoadipate
alpha-Oxoadipic acid
2-ketoadipate
a-oxoadipic acid
.alpha.-Ketoadipic acid
a-Ketoadipate
a-Oxoadipate
alpha-Oxoadipate
2-keto-adipate
a-Ketoadipic acid
BB72FKL1M2
2-Oxo-hexanedioate
2-OXOADIPIC ACID, 98
2-oxohexanedionic acid
.ALPHA.-OXOADIPIC ACID
CHEBI:15753
FGSBNBBHOZHUBO-UHFFFAOYSA-
DTXSID20185702
alpha-ketoadipate
UNII-BB72FKL1M2
alpha-ketodipate
OOG
2-Oxohexanedioicacid
alpha-keto-adipic acid
2-Oxohexanedioic acid #
Oxoadipic acid (Standard)
SCHEMBL27768
GTPL4657
HEXANEDIOIC ACID,2-OXO-
DTXCID20108193
DAA18435
LMFA01170121
AKOS006230506
HY-113227R
2-Oxoadipic acid, >=95.0% (HPLC)
AS-57416
DS-016470
HY-113227
CS-0059355
Hexanedioic acid, 2-oxo- (7CI,8CI,9CI)
NS00006991
C00322
Q2823207
636-531-5