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2-Methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine

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Identification
Molecular formula
C16H18N2
CAS number
NA
IUPAC name
2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
State
State

At room temperature, this compound is a solid. Its crystalline nature can make it appear as a fine powder or small crystals.

Melting point (Celsius)
203.00
Melting point (Kelvin)
476.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
236.32g/mol
Molar mass
236.3160g/mol
Density
1.2250g/cm3
Appearence

The compound is typically found as a crystalline solid. It can appear as off-white to pale yellow powder, depending on the purity and specific form it is in.

Comment on solubility

Solubility of 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine

The solubility of 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine (C16H18N2) is an intriguing aspect that can affect its usage in various chemical applications. Understanding the solubility characteristics of this compound involves considering several factors:

  • Polarity: As a relatively non-polar structure due to its hydrocarbon components, this compound is likely to have limited solubility in polar solvents.
  • Solvent Compatibility: It may dissolve well in non-polar solvents such as hydrocarbons or organic solvents like ethyl acetate. However, its solubility in water is expected to be quite low.
  • Temperature Influence: The solubility can also be affected by temperature changes. Increased temperature typically enhances solubility for most organic compounds.
  • Functional Group Effects: The presence of amine groups suggests potential interactions that might slightly improve solubility in hydrogen-bonding solvents, albeit still limited.

In summary, while 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine displays certain solubility traits, its overall solubility is generally constrained by its structural characteristics. It's essential to rely on empirical data for precise solubility metrics in various solvents.

Interesting facts

Interesting Facts about 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine

2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine is an intriguing compound that falls within the class of isoquinoline derivatives, which are of great interest in medicinal chemistry. Here are some noteworthy aspects of this compound:

  • Isoquinoline Framework: The structure of this compound features a rich aromatic ring system known as isoquinoline, which has been noted for various biological activities.
  • Potential Pharmacological Uses: Compounds containing isoquinoline structures often exhibit a range of pharmacological properties, including antidepressant, antipsychotic, and antitumor activities. This particular compound is being studied for its potential effectiveness in treating certain neurological disorders.
  • Synthetic Versatility: The synthesis of derivatives like 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine can often be achieved through various chemical transformations. This allows researchers to create analogs with modified properties to explore structure-activity relationships.
  • Research Interest: This compound has garnered attention in recent research focused on neuromodulation and receptor interaction, making it a candidate for exploring drug development in the fields of neuroscience and psychiatry.

As scientists delve deeper into the unique characteristics of this compound, it presents exciting opportunities for the discovery of novel therapeutic agents that could revolutionize treatment protocols in modern medicine.

Synonyms
Nomifensine
24526-64-5
nomifensin
2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
Linamiphen
(+-)-Nomifensin
(+-)-Nomifensine
Nomifensina
Nomifenison
Nomifensinum
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
Nomifensinum [INN-Latin]
D,L-nomifensine
Nomifensina [INN-Spanish]
Nomifensine [INN:BAN]
Nomiphensine
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
R/S-nomifensine
(+/-)-Nomifensin
(+/-)-Nomifensine
CCRIS 9179
2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
UNII-1LGS5JRP31
1LGS5JRP31
DTXSID0023377
HSDB 7702
CHEBI:116225
NOMIFENSINE [MI]
8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
NOMIFENSINE [INN]
NOMIFENSINE [HSDB]
Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-
NOMIFENSINE [WHO-DD]
1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine
CHEMBL273575
DTXCID803377
Isoquinoline, 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-
Nomifensinum (INN-Latin)
Nomifensina (INN-Spanish)
(+/-)-Nomifensine maleat
Nomifensine Maleate (1:1)
2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-8-YLAMINE
Nomifensine maleate(USAN)
8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinolin
MFCD00242716
()-Nomifensine maleat
Spectrum_000899
Prestwick0_000108
Prestwick1_000108
Prestwick2_000108
Prestwick3_000108
Spectrum2_001548
Spectrum3_000963
Spectrum4_001079
Spectrum5_001004
Lopac0_000875
SCHEMBL49380
BSPBio_000096
BSPBio_002565
KBioGR_001438
KBioSS_001379
DivK1c_000789
SPBio_001396
SPBio_002035
BPBio1_000106
GTPL4792
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine)
KBio1_000789
KBio2_001379
KBio2_003947
KBio2_006515
KBio3_001785
N06AX04
NINDS_000789
BCP13731
HY-B1110
Tox21_301755
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-(9CI)
BDBM50005548
EX-A10994
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine 2-butenedioate
AKOS015919487
CCG-204957
CS-4708
DB04821
SDCCGSBI-0050850.P004
IDI1_000789
NCGC00015727-03
NCGC00015727-04
NCGC00015727-06
NCGC00015727-07
NCGC00015727-15
NCGC00089794-02
NCGC00255316-01
AC-31222
BS-22102
DA-18354
SBI-0050850.P003
CAS-24526-64-5
AB00053664
NS00099754
AB00053664_13
AB00053664_14
EN300-7376971
L001242
Q409948
BRD-A29644307-050-05-5
BRD-A29644307-050-10-5
BRD-A29644307-050-16-2
BRD-A29644307-050-17-0
BRD-A29644307-050-18-8
((c)I)-Nomifensin B(Z)-4-Hydroxy-4-Oxo-But-2-Enoate
2-Methyl-4-phenyl-1,2,3,4-tetrahydroquinolin-8-amine
Z2216900850
8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline
(+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
(+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
(-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
(Nomifensine) 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine (Nomifensine)
NOMIFENSINE2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
2-Methyl-4-phenyl-1 pound not2 pound not3 pound not4-tetrahydroisoquinolin-8-amine
118184-50-2
963-274-9