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Adefovir

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Identification
Molecular formula
C9H12N5O4PS
CAS number
106941-25-7
IUPAC name
2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]tetrahydrofuran-3,4-diol
State
State

Adefovir is solid at room temperature, appearing as a crystalline powder in its pure form.

Melting point (Celsius)
281.60
Melting point (Kelvin)
554.75
Boiling point (Celsius)
293.22
Boiling point (Kelvin)
566.37
General information
Molecular weight
273.25g/mol
Molar mass
273.2450g/mol
Density
3.0601g/cm3
Appearence

Adefovir typically appears as a white to off-white powder. Its appearance as a pharmaceutical compound may vary depending on the formulation used for therapeutic purposes.

Comment on solubility

Solubility of 2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]tetrahydrofuran-3,4-diol

The solubility of 2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]tetrahydrofuran-3,4-diol (C9H12N5O4PS) can be influenced by several factors, making it a compound of interest in various chemical contexts. Understanding its solubility characteristics is crucial, especially for applications in pharmaceuticals and biochemistry.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxymethyl and sulfonyl groups may enhance its polarity, likely leading to increased solubility in polar solvents such as water.
  • Hydrogen Bonding: The -OH groups can participate in hydrogen bonding, potentially contributing to solubility in aqueous environments.
  • pH Dependency: The solubility may vary depending on the pH of the solution; at different pH levels, protonation or deprotonation can affect its solubility.
  • Solvent Choice: While it may be soluble in water, organic solvents like ethanol or DMSO could also be effective, considering the organic nature of the compound.

In practice, it may be observed that "specific solubility conditions" yield varied results depending on the solvent used and the temperature of the system. Therefore, experiments should be conducted under controlled conditions to accurately assess solubility. Understanding these attributes can greatly assist in the development and application of this compound in various fields.

Interesting facts

Interesting Facts about 2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]tetrahydrofuran-3,4-diol

This fascinating compound stands out in the field of medicinal chemistry and has various intriguing properties. Here are some noteworthy points:

  • Pharmaceutical Potential: As a purine derivative, this compound plays a significant role in the development of various pharmaceuticals, particularly those aimed at treating viral infections and cancers.
  • Complex Structure: The compound features a unique tetrahydrofuran ring, which contributes to its biological activity by enhancing the interaction with biological targets.
  • Targeting Mechanism: The inclusion of the 4-nitrophenyl group suggests potential applications in targeted therapy due to its ability to act as a bioactive moiety, providing specific interactions with certain enzymes or receptors.
  • Instrumentation: Characterizing such complex compounds often requires sophisticated analytical techniques, including NMR, mass spectrometry, and X-ray crystallography, to elucidate their structures and confirm their purity.
  • Research Interest: Due to its multifaceted nature, ongoing research is exploring its effects on cellular processes, including its role in nucleotide metabolism and its implications in genetic material function.

In the words of a renowned chemist, "A single molecule can unlock the mysteries of life and disease; understanding their complexity is the key to progress." This compound exemplifies that philosophy, offering many opportunities for exploration and advancement in the field of chemistry.

Overall, 2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]tetrahydrofuran-3,4-diol is a prime example of how intricate structures can lead to profound implications in science and medicine. Its study continues to be relevant and essential for developing new therapeutic strategies.

Synonyms
S-(4-Nitrobenzyl)-6-thioinosine
2-(hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol
2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
1294455-79-0
6-(p-Nitrobenzylthio)inosine
Oprea1_621177
NSC-296962
SCHEMBL290702
CHEMBL306550
4-Nitrobenzyl-6-mercaptoinosine
DTXSID10860551
HMS3370O01
NSC296962
ZINC13818312
AKOS021983903
NCGC00015732-02
NCGC00163303-01
DB-049231
SR-01000393938
SR-01000393938-1
6-{[(4-Nitrophenyl)methyl]sulfanyl}-9-pentofuranosyl-9H-purine
9H-Purine, 6-[[(4-nitrophenyl)methyl]thio]-9-.beta.-D-ribofuranosyl-
2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}-9H-purin-9-yl)oxolane-3,4-diol