Skip to main content

6-Hydroxynicotinic acid

ADVERTISEMENT
Identification
Molecular formula
C6H5NO4
CAS number
5006-66-6
IUPAC name
2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid
State
State

At room temperature, 6-hydroxynicotinic acid is typically found in the solid state. It is often available as a crystalline powder and is used in research and industrial applications due to its stability in this form.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
377.85
Boiling point (Kelvin)
651.00
General information
Molecular weight
155.11g/mol
Molar mass
153.1110g/mol
Density
2.0780g/cm3
Appearence

6-Hydroxynicotinic acid typically appears as off-white or light brown crystalline powder. It is slightly soluble in water and may form solutions of varying color based on pH and concentration.

Comment on solubility

Solubility of 2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid

The solubility of 2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid is influenced by several factors. This compound exhibits a complex behavior when in contact with various solvents:

  • Polar Solvents: It is generally soluble in polar solvents such as water and alcohols due to its multiple functional groups that can engage in hydrogen bonding.
  • Non-polar Solvents: In contrast, its solubility in non-polar solvents, like hexane or benzene, is minimal due to the lack of sufficient polar interactions.
  • pH Dependence: The solubility also tends to vary with pH changes; the presence of acidic or basic environments can further enhance the solvate interactions, making it more soluble.
  • Temperature Variations: Increasing the temperature typically increases solubility as kinetic energy allows for better molecular dispersion.

In summary, the compound 2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid demonstrates significant solubility in polar solvents due to its ability to form hydrogen bonds. Understanding these solubility characteristics is essential for effective applications in chemical reactions and formulations.

Interesting facts

Interesting Facts about 2-Hydroxy-6-Oxo-1H-Pyridine-4-Carboxylic Acid

2-Hydroxy-6-oxo-1H-pyridine-4-carboxylic acid, commonly known as HOPCA, is a fascinating chemical compound with significant relevance in various fields including biochemistry and pharmaceuticals. Here are some intriguing aspects of this compound:

  • Natural Occurrence: HOPCA is a precursor to vital biological molecules, making it a subject of study in natural product chemistry.
  • Enzymatic Reactions: This compound is involved in enzymatic processes, especially in metabolic pathways related to the synthesis of nucleotides.
  • Biological Activity: HOPCA has shown potential biological activity, including antimicrobial and antioxidant properties, which can be useful in developing new therapeutic agents.
  • Citrate Interactions: It can interact with citrate in metabolic pathways, influencing cellular functions and energy production.
  • Research Tool: Due to its structure, HOPCA is often utilized in research to explore the mechanisms of biochemical reactions and the development of novel pharmaceuticals.

To quote a well-known chemist: "Understanding the role of compounds like 2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid can unravel the intricate pathways of life itself." This compound serves as a bridge between simple organic molecules and complex biological systems, highlighting the elegance of chemistry in nature.

Overall, HOPCA is not just a chemical compound but a key player in the ongoing exploration of biochemical phenomena.

Synonyms
CITRAZINIC ACID
99-11-6
2,6-Dihydroxyisonicotinic acid
2,6-Dihydroxypyridine-4-carboxylic acid
2,6-Dihydroxy-4-carboxypyridine
2,6-Dihydroxy-4-pyridinecarboxylic acid
Kyselina citrazinova
2-hydroxy-6-oxo-1H-pyridine-4-carboxylic acid
2,6-Dihydroxyisonicotinate
4-Pyridinecarboxylic acid, 1,2-dihydro-6-hydroxy-2-oxo-
Kyselina citrazinova [Czech]
4-Pyridinecarboxylic acid, 2,6-dihydroxy-
MFCD00006274
6-Hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylic acid
Isonicotinic acid, 2,6-dihydroxy-
EINECS 202-731-2
N8Q4XFV86A
NSC 41334
Isonicotinic acid, 1,2-dihydro-6-hydroxy-2-oxo-
NSC-5214
NSC-41334
CITRAZINIC ACID [MI]
6-Hydroxy-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid
DTXSID3059185
6-Hydroxy-4-carboxy-2-pyridone
1,2-Dihydro-6-hydroxy-2-oxo-4-pyridinecarboxylic acid
CitrazinicAcid
WLN: T6NJ BQ DVQ FQ
Isonicotinic acid,6-dihydroxy-
4-Pyridinecarboxylic acid,6-dihydroxy-
4-Pyridinecarboxylic acid,2-dihydro-6-hydroxy-2-oxo-
UNII-N8Q4XFV86A
Citrazinc acid
Maybridge4_003590
Oprea1_725973
SCHEMBL185046
SCHEMBL8957131
CHEMBL2048371
DTXCID8049094
Citrazinic acid (2,6-Dihydroxypyridine-4-carboxylic acid)
NSC5214
CHEBI:184700
HMS1531D04
BBL004463
Isonicotinic acid, 2,6-dihydroxy-,
STK378282
AKOS000114790
AKOS000301520
AB00673
BS-3855
BP-30063
SY009490
DB-346541
CS-0067136
NS00020127
EN300-00809
2,6-Dihydroxypyridine-4-carboxylic acid, 97%
2,6-Dihydroxy-isoNicotinic acid (Citrazinic acid)
AE-562/40806835
Q5122816
Z56855768
F2191-0236
6-Hydroxy-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid #
202-731-2