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5-Nitrosalicylic acid

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Identification
Molecular formula
C7H5NO5
CAS number
96-97-9
IUPAC name
2-hydroxy-5-nitro-benzoic acid
State
State

At room temperature, it is generally found as a solid powder. Given its crystalline structure, it remains stable under standard conditions without any significant evaporation or sublimation.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.00
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.00
General information
Molecular weight
183.12g/mol
Molar mass
183.1240g/mol
Density
1.6014g/cm3
Appearence

5-Nitrosalicylic acid is a light yellow crystalline powder. It may appear slightly granular to the naked eye depending on the purity and particle size.

Comment on solubility

Solubility of 2-hydroxy-5-nitro-benzoic acid

2-hydroxy-5-nitro-benzoic acid, commonly known as salicylic acid, exhibits interesting solubility characteristics that depend on various factors, including temperature and pH. Here are some key points about its solubility:

  • Aqueous Solubility: This compound is moderately soluble in water, with solubility increasing significantly in alkaline solutions due to ionization.
  • Solvents: It dissolves well in organic solvents such as ethanol, methanol, and acetone, facilitating its use in various applications.
  • pH Dependence: The solubility is notably enhanced in alkaline conditions because it can form carboxylate ions, which are more soluble in water.
  • Temperature Effects: Like many organic compounds, the solubility in water can increase with temperature, making warming a common method to dissolve it completely.

In summary, the solubility of 2-hydroxy-5-nitro-benzoic acid is influenced by the solvent type, pH, and temperature, which play crucial roles in its practical applications in both laboratory and industrial settings. As quoted in research, "understanding the solubility profiles of organic acids is essential for optimizing their performance in various formulations."


Interesting facts

Interesting Facts about 2-Hydroxy-5-nitro-benzoic Acid

2-Hydroxy-5-nitro-benzoic acid, a fascinating compound in the world of chemistry, is recognized for its unique properties and applications. Here are some interesting highlights:

  • Functional Groups: This compound features both a hydroxyl group (-OH) and a nitro group (-NO2) on the benzene ring, which can significantly influence its reactivity and interaction with other molecules.
  • Applications: It serves as an important building block in the synthesis of various pharmaceuticals and agrochemicals. Its derivatives are often explored for their potential in drug development.
  • Biological Significance: The hydroxyl group positions on the aromatic ring can enhance biological activity, making this compound of particular interest in biological studies, including anti-inflammatory properties.
  • Analytical Chemistry: Its unique structure allows for easy detection and quantification using methods such as UV-Vis spectroscopy, which is pivotal in environmental monitoring and quality control.
  • Historical Context: The study of substituted benzoic acids has long contributed to the growth of organic chemistry, leading to advancements in synthetic methods and the understanding of aromatic compounds.

Renowned chemist Linus Pauling once stated, “The best way to have a good idea is to have a lot of ideas.” The exploration of compounds like 2-hydroxy-5-nitro-benzoic acid encourages innovative thinking and research, showcasing the beauty and complexity of chemical science.

Overall, this compound exemplifies the intricate interplay between structure and function in organic chemistry, providing ample opportunities for ongoing research and discovery.

Synonyms
5-Nitrosalicylic acid
2-Hydroxy-5-nitrobenzoic acid
96-97-9
Anilotic acid
Benzoic acid, 2-hydroxy-5-nitro-
5-Nitro-2-hydroxybenzoic acid
2-hydroxy-5-nitro-benzoic acid
Salicylic acid, 5-nitro-
MFCD00007338
82L9G7FYZ3
CHEBI:61281
5-nitro-salicylic acid
NSC 183
NSC-183
EINECS 202-548-8
AI3-08840
DTXSID2059142
EC 202-548-8
5-NITROSALICYLIC ACID [MI]
2-Hydroxy-5-nitrobenzoic acid, 99%
MESALAZINE IMPURITY N [EP IMPURITY]
2-hydroxy-5-nitrobenzoic acid (5-nitrosalicylic acid)
MESALAZINE IMPURITY N (EP IMPURITY)
UNII-82L9G7FYZ3
2-Hydroxy-5-nitrobenzoic Acid; Mesalazine Imp. N (EP); 5-Nitrosalicylic Acid; Mesalazine Impurity N
6R7
Salicylic acid, 5nitro
5-nitro salicyclic acid
5NSA
2Hydroxy5nitrobenzoic acid
5Nitro2hydroxybenzoic acid
5-nitro-2-oxido-benzoate
Benzoic acid, 2hydroxy5nitro
5-NITROSALICYCLIC ACID
SCHEMBL129889
NSC183
CHEMBL1940317
DTXCID8048993
Salicylic acid, 5nitro (8CI)
5-nitro-2-oxidanyl-benzoic acid
5-nitrosalicylic acid monohydrate
Salicylic acid, 5-nitro-(8CI)
STK259706
AKOS003241764
CS-W017068
FN38625
HY-W016352
5-nitro-2-hydroxobenzoic acid monohydrate
AC-13724
AS-10805
SY012884
DB-057654
N0257
NS00007123
EN300-41267
C19789
S10804
AK-918/40744396
Q238554
Z276119910
202-548-8