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Fenofibrate

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Identification
Molecular formula
C20H21Cl2NO4
CAS number
49562-28-9
IUPAC name
2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide
State
State

At room temperature, fenofibrate is a solid. It is typically distributed in the form of capsules or tablets for pharmaceutical uses.

Melting point (Celsius)
79.00
Melting point (Kelvin)
352.15
Boiling point (Celsius)
274.00
Boiling point (Kelvin)
547.15
General information
Molecular weight
360.83g/mol
Molar mass
360.8290g/mol
Density
1.3000g/cm3
Appearence

Fenofibrate appears as an odorless, white crystalline powder. It is not soluble in water but is soluble in alcohols and acetone.

Comment on solubility

Solubility of 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide

The solubility of 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide (C20H21Cl2NO4) can be quite complex due to its intricate molecular structure. Some key points to consider regarding its solubility include:

  • Polarity: The presence of multiple hydroxyl groups suggests that the compound may exhibit increased polarity, which could enhance its solubility in polar solvents such as water.
  • Hydrophobic regions: The trifluoromethyl group and aromatic rings in the structure may contribute to hydrophobic characteristics, potentially reducing solubility in aqueous environments.
  • Amphiphilicity: This compound appears to have both hydrophilic and hydrophobic sections, which might allow it to dissolve in various solvents, particularly organic solvents.

As a result, the solubility in specific solvents is likely to depend heavily on the solvent's polarity as well as temperature conditions. In general, it's advisable to conduct empirical solubility tests under various conditions to derive definitive solubility profiles for practical applications.

Interesting facts

Interesting Facts about 2-Hydroxy-5-[2-[[2-Hydroxy-3-[4-[1-Methyl-4-(Trifluoromethyl)Imidazol-2-yl]Phenoxy]Propyl]Amino]Ethoxy]Benzamide

This complex compound, known for its intriguing molecular structure, holds significant potential in the realms of medicinal chemistry and pharmacology. Here are some compelling facts that highlight its importance:

  • Pharmacological Relevance: Compounds like 2-hydroxy derivatives often play essential roles in drug development, serving as starting points for synthesizing various pharmaceuticals that target specific biological pathways.
  • Imidazole Component: The presence of imidazole in the structure, particularly as part of a trifluoromethyl substitution, may enhance the compound's metabolic stability and affinity for biological targets, which are critical factors in drug design.
  • Structure-Activity Relationship (SAR): Understanding how different parts of this molecule contribute to its activity can guide modifications that lead to more effective therapeutics. For example, variations in the hydroxyl groups can drastically alter bioactivity.
  • Potential in Cancer Research: Given the structural attributes that include multiple aromatic rings and functional groups, this compound may exhibit anticancer properties, making it a candidate for further investigation in oncological studies.
  • Synergistic Effects: The carefully designed combination of functional groups suggests potential for synergistic interactions within complex biological systems, enhancing efficacy when used in combination therapies.

In the words of a noted chemist, “Understanding the intricate designs of these compounds is not just the key to discovering new drugs but also a window into the fascinating world of molecular interactions.” The exploration of compounds like 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide can unveil profound insights into the mechanisms of action and development of next-generation therapeutics. This compound serves as a remarkable example of how chemistry continues to address modern medicinal challenges.

Synonyms
CGP-20712
137888-49-4
Cgp 20712
CGP-20712A
2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide
SIO2UEZ19H
CGP20712A
CGP 20712-A
2-hydroxy-5-(2-((2-hydroxy-3-(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenoxy)propyl)amino)ethoxy)benzamide
2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide
UNII-SIO2UEZ19H
81015-67-0
SR-01000076208
1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)-phenoxy]-2-propanol
1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]-phenoxy]-2-propanol
cid_2685
Lopac0_000364
GTPL541
1-(2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazoylyl)phenoxy)-2-propanol methanesulfonate
CHEMBL280822
SCHEMBL10914264
BDBM25746
CHEBI:91628
DTXSID301001709
PDSP1_000800
PDSP1_000801
PDSP2_000788
AKOS032953953
CCG-204459
SDCCGSBI-0050352.P002
NCGC00024944-02
NCGC00024944-03
NCGC00024944-04
NCGC00024944-08
TS-08695
HY-101355
CS-0021207
L000167
SR-01000076208-7
BRD-A31575449-066-07-8
BRD-A31575449-300-01-4
Q27075893
(+/-)-2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1h-imidazol-2-yl]phenoxy]propyl]amino]ethoxy]-benzamide
1-[2-(3 -carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]-phenoxy]-2-propanol
2-hydroxy-5-{2-[(2-hydroxy-3-{4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy}propyl)amino]ethoxy}benzamide; methanesulfonic acid
2-Hydroxy-5-{2-[(2-hydroxy-3-{4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy}propyl)amino]ethoxy}benzene-1-carboximidic acid
BENZAMIDE, 2-HYDROXY-5-(2-((2-HYDROXY-3-(4-(1-METHYL-4-(TRIFLUOROMETHYL)-1H-IMIDAZOL-2-YL)PHENOXY)PROPYL)AMINO)ETHOXY)-, (+/-)-