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2-fluoroacetic acid

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Identification
Molecular formula
C2H3FO2
CAS number
144-49-0
IUPAC name
2-fluoroacetic acid
State
State

2-Fluoroacetic acid is a liquid at room temperature.

Melting point (Celsius)
35.00
Melting point (Kelvin)
308.15
Boiling point (Celsius)
162.00
Boiling point (Kelvin)
435.15
General information
Molecular weight
78.04g/mol
Molar mass
78.0390g/mol
Density
1.3710g/cm3
Appearence

2-Fluoroacetic acid is a colorless liquid with a pungent and unpleasant odor. It is typically found in its liquid form under standard conditions.

Comment on solubility

Solubility of 2-fluoroacetic acid (C2H3FO2)

2-fluoroacetic acid is known for its significant solubility in various solvents, an important characteristic in both chemical research and industrial applications. Here are some key points regarding its solubility:

  • Highly soluble in water: 2-fluoroacetic acid exhibits high solubility in water due to its ability to form hydrogen bonds with water molecules, which enhances its dissolution.
  • Solubility in organic solvents: This compound also shows solubility in several organic solvents, including ethanol and ether, making it versatile for use in organic chemistry.
  • Temperature dependent: The solubility can vary with temperature; generally, increasing temperature can enhance solubility in both water and organic solvents.
  • Influence of pH: The acidic nature of 2-fluoroacetic acid contributes to its solubility characteristics; its deprotonated form may be more soluble under certain high pH conditions.

Overall, the solubility of 2-fluoroacetic acid is a key aspect that facilitates its use in various chemical reactions, particularly in synthesis where such properties are advantageous.

Interesting facts

Interesting Facts about 2-Fluoroacetic Acid

2-Fluoroacetic acid is a fascinating compound with a variety of uses and implications in different fields of science. Below are some noteworthy aspects of this intriguing chemical:

  • Structure and Reactivity: The presence of a fluorine atom in the acetic acid structure significantly influences its chemical reactivity. Fluorinated compounds often exhibit enhanced reactivity compared to their non-fluorinated counterparts due to the strong electronegativity of fluorine.
  • Biological Significance: 2-Fluoroacetic acid plays a critical role in biological studies, especially in the context of metabolic pathways. The compound is known to inhibit the energy-production processes in certain organisms, making it a valuable tool in examining metabolic functions.
  • Applications in Agriculture: This compound has been explored as a potential herbicide, showcasing its ability to selectively target specific plant pathways. Its potential as a herbicide underscores the importance of carefully evaluating the ecological impacts of using fluorinated compounds.
  • Safety Concerns: Due to its toxicity, 2-fluoroacetic acid must be handled with extreme care. It is a potent inhibitor of metabolic functions and can be harmful to both humans and wildlife, highlighting the necessity for stringent safety protocols during its use.
  • Analytical Techniques: Scientists often employ sophisticated analytical techniques such as NMR and mass spectrometry for the detection and quantification of 2-fluoroacetic acid in various samples. These methods illustrate the intricate connection between chemistry and analytical methods.

In conclusion, 2-fluoroacetic acid is not only a compound of chemical interest but also a compound that bridges various scientific disciplines, from biology to agriculture to analytical chemistry. Its unfolding role continues to inspire further research, making it a remarkable topic of study.

Synonyms
FLUOROACETIC ACID
2-Fluoroacetic acid
144-49-0
Cymonic acid
Gifblaar poison
Monofluoroacetic acid
Fluoroethanoic acid
Acetic acid, fluoro-
Monofluoressigsaure
Acetic acid, 2-fluoro-
Acide-monofluoracetique
Monofluorazijnzuur
Acido monofluoroacetio
Caswell No. 462
Monofluorazijnzuur [Dutch]
Acido monofluoracetio
Monofluoressigsaure [German]
Acido monofluoracetio [Italian]
Acide-monofluoracetique [French]
Acido monofluoroacetio [Italian]
HSDB 2082
UNII-AP1JV9U41M
EINECS 205-631-7
AP1JV9U41M
UN2642
EPA Pesticide Chemical Code 075001
UN 2642
BRN 1739053
MFA (Salt/Mix)
DTXSID0041981
HFA
CHEBI:30775
AI3-28547
CH2FCOOH
Monofluoroacetate
FLUOROACETIC ACID [MI]
DTXCID8021981
FLUOROACETIC ACID [HSDB]
4-02-00-00446 (Beilstein Handbook Reference)
Monofluorazijnzuur (Dutch)
Monofluoressigsaure (German)
Alpha-fluoroacetic acid
Acido monofluoracetio (Italian)
Acide-monofluoracetique (French)
fluoroaceticacid
fluoro-acetic acid
2Fluoroacetic acid
FAH
Acetic acid, fluoro
Acidemonofluoracetique
Fluoroacetate (FAC)
Spectrum_001872
SpecPlus_000915
Fluoroacetic acid, 95%
NCIOpen2_000661
KBioSS_002392
DivK1c_007011
CHEMBL509273
KBio1_001955
KBio2_002387
KBio2_004955
KBio2_007523
DTXSID30200339
Tox21_302429
MFCD00039529
AKOS006230216
FF77128
USEPA/OPP Pesticide Code: 075001
Fluoroacetic acid [UN2642] [Poison]
NCGC00255974-01
CAS-144-49-0
NS00008445
C06108
Q420215
205-631-7