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Tramadol

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Identification
Molecular formula
C16H25NO2
CAS number
27203-92-5
IUPAC name
2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
State
State

At room temperature, tramadol is in a solid state, typically available as a fine powder.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
263.38g/mol
Molar mass
263.3830g/mol
Density
1.2235g/cm3
Appearence

Tramadol typically appears as a white crystalline powder. It is odorless and has a bitter taste, generally used in various pharmaceutical formulations such as tablets and capsules.

Comment on solubility

Solubility of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

The solubility of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol (C16H25NO2) is governed by several factors, primarily its molecular structure and the presence of polar functional groups. Here are some key points regarding its solubility:

  • Hydrophilicity vs Hydrophobicity: The presence of the dimethylamino group contributes to its overall hydrophilicity, enhancing solubility in polar solvents, while the cyclohexanol moiety adds some hydrophobic characteristics.
  • Polar Solvent Compatibility: This compound is likely to have good solubility in water due to its polar functional groups, making it suitable for applications in various aqueous environments.
  • Organic Solvent Solubility: It may also dissolve well in common organic solvents like ethanol or methanol, facilitating its use in organic reactions and formulations.
  • Temperature Effects: Like many organic compounds, its solubility can increase with temperature, which should be considered when preparing solutions.

In summary, the solubility of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol reflects the balance between its polar and non-polar characteristics, leading to favorable interactions with both polar and non-polar solvents under appropriate conditions.

Interesting facts

Interesting Facts about 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

This compound, often referred to in the context of pharmacological research, exhibits intriguing properties that make it a subject of interest among chemists and pharmacologists alike. Below are some key points that highlight its significance:

  • Pharmacological Potential: This compound is noted for its potential therapeutic effects, particularly in the realm of neurological research. It may possess properties that could impact serotonin and norepinephrine levels, which are crucial for mood regulation.
  • Chemical Structure: The structural composition of this compound includes a cyclohexanol moiety that contributes to its unique biological activity and interactions within the body. The presence of a dimethylamino group enhances its lipophilicity, often affecting how well it can cross biological membranes.
  • Importance of Substituents: The methoxy group present in the phenyl ring is significant. Methoxy substitutions are known to modulate the activity of compounds in medicinal chemistry, potentially altering receptor affinity and selectivity.
  • Research Applications: Compounds like this one are often investigated for their roles in treating various disorders. Understanding how it interacts with biological systems can lead to new therapies for conditions related to mood disorders or pain management.
  • Analytical Techniques: Scientists frequently employ advanced techniques such as mass spectrometry and NMR spectroscopy to analyze and understand the properties and behaviors of this compound in different environments.

As research progresses, compounds like 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol may continue to unveil new insights into therapeutic strategies, thereby proving the adage that "the best is yet to come" in pharmaceutical science.

Synonyms
Ultram
2914-77-4
2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXAN-1-OL
2-Dimethylaminomethyl-1-(m-methoxyphenyl)cyclohexanol
cis,trans-(+-)-L 201
Cyclohexanol, 2-(dimethylaminomethyl)-1-(m-methoxyphenyl)-
NIOSH/GV8924900
CHEBI:75722
2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
GV89249000
Maxitram
Tilodol
2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
Cyclohexanol, 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-, (+-)-cis,trans-
EINECS 220-831-4
Adolonta
SCHEMBL57496
tramadol (not stereospecific)
GTPL8286
(1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclo-hexanol
CHEMBL1237044
DTXSID00860388
Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-
181289-58-7
GHA28958
GHA28959
AKOS022507395
FT28359
FM172554
(1R,2S)-2-[(Dimethylamino)Methyl]-1-(3-Methoxyphenyl)Cyclohexanol Hydrochloride
DB-226678
DS-015928
NS00083054
L000985
Q27089018
(1r,2s)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
(1RS,2RS)-2-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexanol
Cyclohexanol, 2-a[(dimethylamino)amethyl]a-a1-a(3-amethoxyphenyl)a-
(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol;(1R-cis)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol