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Procaine

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Identification
Molecular formula
C13H20N2O2
CAS number
59-46-1
IUPAC name
2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate
State
State

Procaine is typically found as a solid in its pure form at room temperature. It is commonly used as a hydrochloride salt, and in this form, it may also appear as a crystalline solid, which is stable under normal conditions.

Melting point (Celsius)
60.50
Melting point (Kelvin)
333.65
Boiling point (Celsius)
424.20
Boiling point (Kelvin)
697.35
General information
Molecular weight
236.31g/mol
Molar mass
236.3100g/mol
Density
1.1720g/cm3
Appearence

Procaine is a white crystalline powder. It is odorless and tasteless, making it distinct and recognizable in its pure form. The compound is often used in its hydrochloride form, which is also a white crystalline substance, soluble in water.

Comment on solubility

Solubility of 2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate

The solubility of 2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate in various solvents is of significant interest due to its unique chemical structure. Understanding its solubility behavior can greatly impact its practical applications. Here are some key points to consider:

  • Polar vs. Nonpolar Solvents: This compound, with both polar and nonpolar characteristics, shows varying solubility in different solvents. It is expected to be soluble in polar solvents such as water or methanol, but might demonstrate limited solubility in nonpolar solvents like hexane.
  • pH Dependency: The solubility may also be affected by the pH of the solution due to the presence of amino groups, which can undergo protonation or deprotonation. This characteristic can make the compound more soluble in acidic conditions and less soluble in neutral or basic conditions.
  • Temperature Influence: Increasing the temperature generally enhances solubility. Thus, solubilization processes may be more efficient at higher temperatures, promoting better dissolution rates.
  • Structure and Interaction: The diethylamino group contributes to its solubility properties, as amino groups can engage in hydrogen bonding with solvents, enhancing solubility in polar environments.

In conclusion, the solubility of 2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate is influenced by several factors, particularly the choice of solvent, pH levels, and temperature. Understanding these factors is crucial for effective utilization in both research and industrial applications.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate

2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate is a fascinating compound with several noteworthy characteristics:

  • Pharmaceutical Applications: This compound plays a significant role in medicinal chemistry. It is often explored for its potential as a drug candidate, particularly in the context of developing therapies for various diseases.
  • Structure-Activity Relationship (SAR): Understanding its structure helps researchers deduce how modifications can enhance desired biological activity. The presence of the diethylamino group significantly influences its pharmacokinetic properties.
  • Research Interest: The compound is often a subject of interest in studies related to neuropharmacology, due to its interaction with neurotransmitter systems.
  • Versatile Synthesis: Its synthesis can be accomplished through various synthetic routes, making it versatile for students and researchers aiming to explore chemical reactions.
  • Analytical Techniques: Characterizing this compound involves a variety of analytical techniques such as NMR, IR spectroscopy, and mass spectrometry, providing students with hands-on experience in practical chemistry.

In summary, 2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate stands out not only for its potential therapeutic uses but also as a compelling subject of study in **chemical synthesis** and **structure-activity relationships**. Its intriguing composition offers ample opportunities for exploration in both academic and industrial settings.

Synonyms
Propoxycaine
86-43-1
2-(diethylamino)ethyl 4-amino-2-propoxybenzoate
Pravocaine
Ranocaine
Propoxicainum
Blockain
Propoxycaine [INN]
Propoxicaina
Propossicaina
Propoxycainum
Propossicaina [DCIT]
Propoxycainum [INN-Latin]
Propoxicaina [INN-Spanish]
2-Diethylaminoethyl 4-amino-2-propoxybenzoate
Win 3459-2
4-Amino-2-propoxybenzoic acid, 2-(diethylamino)ethyl ester
UNII-EPD1EH7F53
EINECS 201-670-9
EPD1EH7F53
2'-Diethylaminoethyl 2-propoxy-4-aminobenzoate
BRN 2382110
CHEBI:8496
BENZOIC ACID, 4-AMINO-2-PROPOXY-, 2-(DIETHYLAMINO)ETHYL ESTER
2-Diethylaminoethyl 4-amino-2-propoxybenzoic acid ester
PROPOXYCAINE [WHO-DD]
DTXSID6047866
4-14-00-01986 (Beilstein Handbook Reference)
Propoxycainum (INN-Latin)
Propoxicaina (INN-Spanish)
2-(diethylamino)ethyl 4-amino-2-propoxy-benzoate
Propoxyprocaine
NCGC00016505-01
CAS-550-83-4
Prestwick0_001059
Prestwick1_001059
Prestwick2_001059
Prestwick3_001059
CHEMBL1195
SCHEMBL83073
BSPBio_001018
SPBio_002939
BPBio1_001120
DTXCID6027842
BDBM50225492
DB09342
SB82647
NCGC00016505-02
NCGC00016505-04
NCGC00016505-06
AB00514714
NS00015460
2-(diethylamino)ethyl4-amino-2-propoxybenzoate
C07895
G87214
AB00514714_06
EN300-18562918
Q7250421
BRD-K18250272-003-03-7
BRD-K18250272-003-11-0
201-670-9