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Tandamine

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Identification
Molecular formula
C25H35NO3
CAS number
.
IUPAC name
2-(diethylamino)ethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate
State
State

At room temperature, tandem is typically in a solid state, appearing as a crystalline substance that may be used in various chemical applications or studies.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
402.90
Boiling point (Kelvin)
676.05
General information
Molecular weight
395.55g/mol
Molar mass
395.5520g/mol
Density
1.1200g/cm3
Appearence

Appearance: Tandamine typically appears as a crystalline solid and may have a white or off-white coloration. Its precise appearance can vary based on the level of purity and specific form (such as salt or base).

Comment on solubility

Solubility of 2-(diethylamino)ethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate

The solubility characteristics of the compound 2-(diethylamino)ethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate, with the chemical formula C25H35NO3, are intriguing due to its complex structure and functional groups. Understanding its solubility can provide insights into its behavior in biological and chemical systems. Here are some key points to consider:

  • Polarity Influences: The presence of both the ether group from tetrahydrofuran and the amine groups from the diethylamino moiety suggests that this compound can have significant interactions with polar solvents.
  • Hydrophobic Interactions: With the incorporation of a naphthyl group, which is a large hydrophobic component, this compound is likely to exhibit reduced solubility in water but may dissolve well in organic solvents like ethanol or dichloromethane.
  • Solubility in Varied Solvents: Its solubility might vary significantly across different media, exhibiting:
    • High solubility in non-polar solvents,
    • Moderate solubility in polar, aprotic solvents, and
    • Low solubility in polar protic solvents such as water.
  • Temperature Effects: As with many organic compounds, solubility may increase with temperature, further enhancing its potential applications.

In summary, the solubility of C25H35NO3 is deeply influenced by its structural characteristics, exhibiting complex interactions that can make it useful in various chemical applications and formulations.

Interesting facts

Interesting Facts about 2-(diethylamino)ethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate

This compound, known for its complex structure, represents an intriguing intersection of medicinal chemistry and organic synthesis. Here are some fascinating aspects:

  • Pharmaceutical Potential: The unique structure of this compound suggests possible applications in drug development, particularly in the field of neuropharmacology. Due to the presence of the 1-naphthylmethyl group, it may exhibit interesting interactions with neurotransmitter receptors.
  • Structure-Activity Relationship: The intricate arrangement of functional groups can lead to varying biological activities. The tetrahydrofuran moiety provides a rigid framework, which is often crucial in developing compounds with high specificity and potency.
  • Diethylamino Group: The diethylamino side chain is notable for its potential influence on the compound's solubility and lipophilicity, which may enhance its ability to penetrate cell membranes, thereby impacting its pharmacokinetics and bioavailability.
  • Source of Inspiration: This compound is an example of how organic chemists can generate novel structures by combining established pharmacophores, showcasing the blend of creativity and methodology in synthetic organic chemistry.
  • Research Interest: Compounds like this are often subjects of research focused on synthesizing derivatives with improved efficacy or reduced toxicity, which is a vital aspect of pharmaceutical development.

In conclusion, 2-(diethylamino)ethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate is not just a chemical structure; it embodies the quest for knowledge in medicinal chemistry, promising valuable insights and potential therapeutic applications.

Synonyms
nafronyl
Naftidrofuryl
31329-57-4
Naphtidrofuryl
Gevatran
Tridus
Naftidrofurilo
Dubimax
Praxilene
Naftidrofurylum
LS 84
Naftidrofuryl [INN:BAN]
Nafronyloxalate
Naftidrofurylum [INN-Latin]
Naftidrofurilo [INN-Spanish]
2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate
Drosunal
Naftifurin Oxalate
UNII-42H8PQ0NMJ
EINECS 250-572-2
Naftiratiopharm
Iridus
BRN 1296059
Dubimax (Salt/Mix)
Nafti ratiopharm
Naftidrofuryl (INN)
Nafti Puren
Di Actane
Oxalate, Nafronyl
NAFRONYL [MI]
Oxalate, Naftifurin
NAFTIDROFURYL [INN]
42H8PQ0NMJ
3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester
2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
NAFTIDROFURYL [WHO-DD]
DTXSID3023344
LS 121
2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
GAvatran
2-(Diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydro-2-furanylmethyl)propanoate
2-Furanpropanoic acid, tetrahydro-.alpha.-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester
Naftidrofurylum (INN-Latin)
Naftidrofurilo (INN-Spanish)
Nafronyl oxalate(USAN)
naftidrofurile
Nafti-ratiopharm
2-(Diethylamino)ethyl tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate
2-(Diethylamino)ethyl ester tetrahydro-.alpha.-(1-naphthalenylmethyl)-2-furanpropanic acid
2-(Diethylamino)ethyl tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropionate ester
CHEMBL1439099
Tetrahydro-.alpha.-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
2-FURANPROPANOIC ACID, TETRAHYDRO-A-(1-NAPHTHALENYLMETHYL)-, 2-(DIETHYLAMINO)ETHYL ESTER
TETRAHYDRO-.ALPHA.-(1-NAPHTHYLMETHYL)-2-FURANPROPIONIC ACID 2-(DIETHYLAMINO)ETHYL ESTER
NSC225233
C24H33NO3
Oxalte
Drosunal (TN)
Spectrum_001731
Prestwick0_000377
Prestwick1_000377
Prestwick2_000377
Prestwick3_000377
Spectrum2_000868
Spectrum3_001598
Spectrum4_000855
Spectrum5_001127
N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate
2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate
alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester
Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
SCHEMBL34062
BSPBio_000533
BSPBio_003196
KBioGR_001489
KBioSS_002211
DivK1c_000338
SPBio_000915
SPBio_002454
BPBio1_000587
DTXCID703344
CHEMBL1620794
CHEBI:91817
KBio1_000338
KBio2_002211
KBio2_004779
KBio2_007347
KBio3_002696
C04AX21
NINDS_000338
BDBM50347133
STL344054
AKOS005068111
DB13588
FT26121
2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester
IDI1_000338
tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionic acid 2-(diethylamino)ethyl ester
NCGC00178213-01
NCGC00178213-02
NCGC00178213-04
SBI-0051824.P002
DB-048011
AB00053667
NS00009221
D08244
AB00053667_10
EN300-7439215
Q425867
BRD-A67862938-034-05-7
BRD-A67862938-034-09-9
BRD-A67862938-034-14-9
2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-(oxolan-2-ylmethyl)propanoate
2-diethylaminoethyl 2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoate
N-Diethylaminoethyl .beta.-(1-naphthyl)-.beta.-tetrahydrofuryl isobutyrate
.alpha.-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester
2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester
2-(Diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydro-2-furanylmethyl)propanoate oxalate
2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-(tetrahydrofuran-2-ylmethyl)propanoate
2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-[(oxolan-2-yl)methyl]propanoate
2-(diethylamino)ethyl 3-naphthalen-1-yl-2-(tetrahydrofuran-2-ylmethyl)propanoate
2-(Diethylamino)ethyl ester tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanic acid
2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate ester
Tetrahydro-.alpha.-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
Tetrahydro-a-(1-naphthalenylmethyl)-2-furanpropanoic Acid 2-(Diethylamino)ethyl Ester
2-Furanpropionic acid, tetrahydro-.alpha.-(1-naphthylmethyl)-, 2-(diethylamino)ethyl esteroxalate (1:1)
250-572-2