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Bupivacaine hydrochloride

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Identification
Molecular formula
C18H29ClN2O
CAS number
14252-80-3
IUPAC name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
State
State

At room temperature, bupivacaine hydrochloride is commonly found as a solid crystalline powder.

Melting point (Celsius)
248.00
Melting point (Kelvin)
521.15
Boiling point (Celsius)
140.00
Boiling point (Kelvin)
413.15
General information
Molecular weight
342.90g/mol
Molar mass
342.9010g/mol
Density
1.0140g/cm3
Appearence

Bupivacaine hydrochloride appears as a white to almost white crystalline powder. It is soluble in water, which is typical for many hydrochloride salts of local anesthetics, facilitating their administration in medical settings.

Comment on solubility

Solubility of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide; hydrochloride

The solubility of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide; hydrochloride (C18H29ClN2O) can be explored through various factors and properties:

  • Polarity: The presence of the hydrochloride salt often increases the polarity of the compound, making it more soluble in polar solvents, particularly water.
  • pH Sensitivity: As a salt, it may exhibit solubility variations depending on the pH of the solution, with increased solubility at lower pH levels.
  • Temperature Influence: Like many compounds, the solubility may increase with higher temperatures; thus, heating the solvent could facilitate dissolution.
  • Common Solvents: This compound is likely to be soluble in common organic solvents like methanol and ethanol, in addition to water.

In summary, the overall solubility of this compound is significantly influenced by its ionic nature as a hydrochloride salt. As such, one might say, “When in doubt, test it out,” highlighting the need for empirical testing to fully understand solubility behavior across different conditions.

Interesting facts

Interesting Facts about 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide Hydrochloride

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride, often referred to by its compound name, is a notable synthetic organic compound with significant applications in the field of medicine. Here are some interesting aspects of this compound:

  • Pharmacological Relevance: This compound serves as an important intermediate in the synthesis of various pharmaceuticals, particularly in the development of analgesics and anesthetics.
  • Structural Features: Its structure features a diethylamino group, which enhances the compound's lipophilicity, allowing it to penetrate biological membranes efficiently.
  • Biological Activity: Compounds of this class often exhibit a range of biological activities, including potential anti-inflammatory and analgesic effects, making it a subject of interest in pharmacological research.
  • Mechanism of Action: Research indicates that similar compounds can act on specific receptors in the nervous system, contributing to pain relief or sedation.
  • Synthesis: The synthesis of this compound typically involves multi-step reactions, which highlights the importance of organic synthesis methodologies in drug development.

As a chemistry student, understanding the significance of such compounds not only enhances knowledge of organic synthesis but also sheds light on how molecular modifications can lead to new therapeutic agents. The study of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride exemplifies how subtle changes in molecular structure can have profound effects on biological activity, illustrating the heart of medicinal chemistry.

In the words of a renowned chemist, "The magic of chemistry lies in the ability to design molecules that can evoke specific responses in biological systems." This compound is a testament to that very magic!

Synonyms
Lidocaine hydrochloride
73-78-9
LIDOCAINE HCL
Xyloneural
Lidothesin
Lignocaine hydrochloride
Xylocaine Viscous
Laryng-O-jet
Xilina hydrochloride
Anestacon
Rucaina hydrochloride
Xycaine hydrochloride
Xylotox hydrochloride
Duncaine hydrochloride
Isicaine hydrochloride
Lidocain hydrochloride
Glydo
Anestacon hydrochloride
Gravocain hydrochloride
Leostesin hydrochloride
Xylocitin hydrochloride
Lidothesin hydrochloride
Xylestesin hydrochloride
LIDOCAINE VISCOUS
LTA II KIT
PEDIATRIC LTA KIT
LARYNG-O-JET KIT
Lidocaine (hydrochloride)
Lidocaine hydrochloride anhydrous
Lidocaton
LIDOPEN
Xylocard
Zingo
Xylocaine hydrochloride
EC2CNF7XFP
UNII-EC2CNF7XFP
XYLOCAINE PRESERVATIVE FREE
EINECS 200-803-8
LARYNGOTRACHEAL ANESTHESIA KIT
XYLOCAINE 4% PRESERVATIVE FREE
Lidocaine hydrochloride viscous
ALPHACAINE HYDROCHLORIDE
2-Diethylamino-2',6'-acetoxylidide hydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride
S 202
V 262
NSC-757420
alpha-Diethylamino-2,6-acetoxylidine hydrochloride
Linocaine hydrochloride
Lidocaine hydrochloride preservative free
N-(Diethylaminoacetyl)-2,6-dimethylaniline hydrochloride
omega-Diethylamino-2,6-dimethylacetanilide hydrochloride
Lidocaine hydrochloride in plastic container
MLS000069665
CHEBI:50512
Lidocaine hydrochloride 0.2% in dextrose 5%
Lidocaine hydrochloride 0.4% in dextrose 5%
Lidocaine hydrochloride 5% and dextrose 7.5%
Dalcaine
Alphacaine N
NSC 757420
Alphacaine SP
ANHYDROUS LIDOCAINE HYDROCHLORIDE
2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride
Lidocaine hydrochloride preservative free in plastic container
SMR000058468
2',6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE
Xylocaine (TN)
Lidocaine hydrochloride 0.1% and dextrose 5% in plastic container
Lidocaine hydrochloride 0.2% and dextrose 5% in plastic container
Lidocaine hydrochloride 0.2% in dextrose 5% in plastic container
Lidocaine hydrochloride 0.4% and dextrose 5% in plastic container
Lidocaine hydrochloride 0.4% in dextrose 5% in plastic container
Lidocaine hydrochloride 0.8% and dextrose 5% in plastic container
Lidocaine hydrochloride 0.8% in dextrose 5% in plastic container
73-78-9 (HCl); 6108-05-0 (monohydrate)
2-(DIETHYLAMINO)-2',6'-ACETOXYLIDIDE MONOHYDROCHLORIDE
CHEBI:60791
LIDOCAINE HYDROCHLORIDE ANHYDROUS (MART.)
LIDOCAINE HYDROCHLORIDE ANHYDROUS [MART.]
LIDOCAINE HYDROCHLORIDE (USP-RS)
SR-01000000189
LIDOCAINE HYDROCHLORIDE (EP IMPURITY)
EMBOLEX COMPONENT LIDOCAINE HYDROCHLORIDE
HBN-1 COMPONENT LIDOCAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE (USP MONOGRAPH)
XYLOCAINE 5% W/ GLUCOSE 7.5%
DUOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
IONTOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE MONOHYDRATE (MART.)
OCTOCAINE COMPONENT LIDOCAINE HYDROCHLORIDE
XYLOCAINE 1.5% W/ DEXTROSE 7.5%
LIDOCAINE HYDROCHLORIDE MONOHYDRATE (EP MONOGRAPH)
LIGNOSPAN FORTE COMPONENT LIDOCAINE HYDROCHLORIDE
Dalcaine (TN)
Prestwick_296
LIDOSITE TOPICAL SYSTEM KIT COMPONENT LIDOCAINE HYDROCHLORIDE
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride
Lidoca ne hydrochloride
XYLOCAINE DENTAL
Opera_ID_351
Lidocaine Monohydrochloride
SPECTRUM1500689
CHEMBL541521
DTXSID4058782
Xylocaine 5% w/glucose 7.5%
HY-B0185A
GLXC-26369
HMS1568I21
HMS1921C22
Pharmakon1600-01500689
Lidocaine hydrochloride (JAN/USP)
BCP30473
PXB95913
Tox21_500669
Xylocaine 1.5% w/dextrose 7.5%
CCG-39281
LIDOCAINE HYDROCHLORIDE [JAN]
NSC757420
s4667
AKOS015889456
CS-3888
LP00669
SB19119
LIDOCAINE HYDROCHLORIDE [WHO-DD]
NCGC00094030-01
NCGC00094030-02
NCGC00094030-03
NCGC00094030-04
NCGC00094030-05
NCGC00261354-01
AC-11712
AS-35171
FL177823
EU-0100669
NS00093551
Lignocaine hydrochloride pound>>Lidocaine HCl
D02086
L 5647
EN300-7398170
A837924
LIDOCAINE HYDROCHLORIDE COMPONENT OF EMBOLEX
LIDOCAINE HYDROCHLORIDE COMPONENT OF HBN-1
2-Diethylamino-n-[2,6-dimethylphenyl]acetamide hcl
LIDOCAINE HYDROCHLORIDE COMPONENT OF DUOCAINE
SR-01000000189-3
SR-01000000189-9
LIDOCAINE HYDROCHLORIDE COMPONENT OF IONTOCAINE
LIDOCAINE HYDROCHLORIDE COMPONENT OF OCTOCAINE
Q27122094
LIDOCAINE HYDROCHLORIDE COMPONENT OF LIGNOSPAN FORTE
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)ethanamide hydrochloride
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
LIDOCAINE HYDROCHLORIDE COMPONENT OF LIDOSITE TOPICAL SYSTEM KIT
200-803-8