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Alogliptin

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Identification
Molecular formula
C18H19F3N2O2
CAS number
850649-62-6
IUPAC name
2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide
State
State

At room temperature, Alogliptin is in a solid state. It is a stable compound under normal conditions of use and storage.

Melting point (Celsius)
139.10
Melting point (Kelvin)
412.30
Boiling point (Celsius)
456.70
Boiling point (Kelvin)
729.90
General information
Molecular weight
339.34g/mol
Molar mass
339.3340g/mol
Density
1.3964g/cm3
Appearence

Alogliptin appears as a crystalline solid in its pure form. It is typically white to light brown in color.

Comment on solubility

Solubility of 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide

The solubility of 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide (C18H19F3N2O2) is an important characteristic that influences its applicability in various chemical processes and formulations. Here are some key points regarding its solubility:

  • Polar groups: The presence of hydroxyl (-OH) and cyano (-C≡N) groups in the molecule typically enhances solubility in polar solvents, such as water.
  • Non-polar characteristics: However, the bulky trifluoromethyl group and the extended carbon backbone may contribute to hydrophobic behavior, possibly limiting its solubility in purely aqueous environments.
  • Overall solubility behavior: Therefore, it is likely that this compound shows:
    • Good solubility in organic solvents like ethanol and methanol
    • Moderate to low solubility in water, influenced by pH and temperature

In summary, while 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide has polar functional groups that may promote solubility in polar media, the effects of its hydrophobic segments must be carefully considered. As with many organic compounds, solubility will vary depending on external conditions such as temperature and pressure.

Interesting facts

Interesting Facts about 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide

This fascinating compound, known as 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide, is noteworthy for its multifunctional properties, with applications in various chemical and pharmaceutical fields. Here are some intriguing aspects of this compound:

  • Structural Diversity: The presence of both a cyano group and a hydroxyl group contributes to its diverse chemical reactivity. This makes it a candidate for further modifications in synthetic chemistry.
  • Fluorination Effects: The trifluoromethyl group enhances the compound's lipophilicity and metabolic stability, which can be critical in drug design and development.
  • Biological Activity: Compounds with hydroxyl and cyano groups are often explored for their biological activities. Research indicates potential use in pharmacology, particularly for analgesic and anti-inflammatory agents.
  • Synthetic Routes: The preparation of this compound involves various synthetic methodologies, showcasing the importance of strategic planning in organic synthesis for achieving desired properties.

As quoted from a renowned chemistry textbook, “the unique properties of compounds often lie within the details of their functional groups.” This compound exemplifies that idea beautifully, combining different functionalities that could lead to innovative applications in medicinal chemistry.

In summary, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide stands out due to its structural features and potential applications, making it a notable subject of study for both chemists and those interested in the pharmaceutical sciences.

Synonyms
ANTIPROLIFERATIVE AGENT A771726
2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]butanamide
YODXEQNROKSLLQ-UHFFFAOYSA-N