Interesting facts
Interesting Facts about 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide
The compound 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide, often referred to in shorthand for ease, holds fascinating aspects in the realm of medicinal chemistry. Here are some compelling points:
- Versatile Pharmacology: Compounds of this class are known for their diverse biological activities. The sulfonamide group is widely recognized for its use in antibiotics and therapeutic agents.
- Innovative Substituents: This compound features a unique combination of a thienyl moiety and a tetrazole ring, which can enhance interaction with biological targets and modulate pharmacokinetic properties.
- Research Frontier: Ongoing studies explore the potential of tetrazole-containing compounds in the development of antifungals, antihypertensives, and anticancer agents.
- Mechanism of Action: By understanding the interactions of such compounds on a molecular level, scientists can design better-targeted therapies with improved efficacy and minimized side effects.
- Structure-Activity Relationship (SAR): Analyzing the SAR of this compound can lead to insights on how alterations in structure impact biological effectiveness and stability.
In conclusion, 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide is an intriguing compound that reflects the complexity and potential of organic synthesis in drug development. As with many chemical entities, the road from the lab to therapeutic use is layered with challenges and opportunities for innovation.
Synonyms
azosemide
27589-33-9
Azosemid
Azosemida
Diart
Azosemidum
Luret
2-chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
Azosemidum [INN-Latin]
Azosemida [INN-Spanish]
PLE 1053
Azosemide [USAN:INN:JAN]
EINECS 248-549-7
MR40VT1L8Z
SK-110
BRN 1178491
Diart (TN)
2-Chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenylsulfanilamide
DTXSID7046910
CHEBI:31248
AZOSEMIDE [INN]
AZOSEMIDE [JAN]
2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
AZOSEMIDE [MI]
AZOSEMIDE [USAN]
AZOSEMIDE [MART.]
AZOSEMIDE [WHO-DD]
Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenyl-
Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-
Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole
5-(4'-Chloro-5'-sulfamoyl-2'-thenylaminophenyl)-tetrazole
DTXCID5026910
2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
2-Chloro-5-(1H-tetrazol-5-yl)-N4-2-thenylsulfanilamide
NCGC00181340-01
Azosemidum (INN-Latin)
Azosemida (INN-Spanish)
AZOSEMIDE (MART.)
C12H11ClN6O2S2
2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide
2-Chloro-5-(1H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzene-1-sulfonamide
CAS-27589-33-9
UNII-MR40VT1L8Z
2-Chloro-5-(1H-tetrazol-5-yl)-4-((thien-2-ylmethyl)amino)benzenesulfonamide
2-Chloro-5-(1H-tetrazol-5-yl)-4-[(thien-2-ylmethyl)amino]benzenesulfonamide
2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzene-1-sulfonamide
IWE
MFCD00867321
5-(4-chloro-5-sulfamyl-2-thienylaminophenyl)tetrazole
SCHEMBL48976
Azosemide (JP17/USAN/INN)
CHEMBL1097235
EX-A1266
Tox21_112799
AC-096
MFCD30541344
SK 110
AKOS015961824
Tox21_112799_1
DB08961
FA44032
NCGC00181340-02
AS-12235
SY288607
DB-047249
HY-107321
CS-0028137
NS00002746
C74435
D01323
Q4832859
BRD-K68770713-001-01-8
5-(4-chloro-5-sulfamoyl-2-thenylaminophenyl)-tetrazole
2-chloro-5-(1H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
2-chloranyl-5-(1~{H}-1,2,3,4-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
248-549-7
Solubility of 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide
The solubility of the compound 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide (C9H9ClN5O2S2) can be an important factor in its practical applications, especially in pharmaceutical settings. Here are some key points regarding its solubility:
In conclusion, while specific solubility data might be limited, understanding these factors can provide insights into the behavior of 2-chloro-5-(2H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide in various environments. Researchers should consider both experimental measurements and theoretical models to explore its solubility comprehensively.