Dichlorobenzenesulfonamide | Solubility of Things

Identification

Molecular formula

C₁₄H₁₁ClN₂O₄S

CAS number

84-69-5

IUPAC name

2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide

State

The compound is usually found in a solid state at room temperature. It is stable under standard conditions and is often handled and stored as a crystalline powder. Care should be taken to store it in a cool, dry place to ensure it remains in this stable, solid state.

Melting point (Celsius)

182.00

Melting point (Kelvin)

455.15

Boiling point (Celsius)

460.00

Boiling point (Kelvin)

733.15

General information

Molecular weight

377.78g/mol

Molar mass

377.8010g/mol

Density

1.5300g/cm³

Appearence

2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide typically appears as a white to off-white powder or crystalline solid. It has a distinct chemical structure, consisting of aromatic benzene rings linked to other functional groups, giving it a complex appearance at the molecular level.

Comment on solubility

Solubility of 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide

The solubility characteristics of 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide (C₁₄H₁₁ClN₂O₄S) exhibit interesting properties that are influenced by its unique chemical structure. Its solubility in various solvents plays a significant role in its potential applications in pharmaceuticals and research.

Solubility Insights

In general, the solubility of a compound like this can be determined by several factors:

Molecular Structure: The presence of multiple functional groups, such as the sulfonamide and hydroxy groups, may enhance its solubility in polar solvents.
Polarity: Compounds exhibiting polar characteristics are often more soluble in polar solvents (e.g., water), whereas non-polar or less polar solvents (e.g., hexane) may dissolve them to a lesser extent.
pH Dependence: The ionization state of the sulfonamide group may change with pH, affecting its solubility. At different pH levels, the solubility may vary significantly.

For optimal use, it is advisable to determine the compound's solubility in specific solvents, keeping in mind:

**Water**: Often serves as a primary solvent for biological applications.
**Ethanol**: Useful for organic synthesis and may promote solubility for organic compounds.
**DMSO**: A common solvent used in drug formulation, especially for polar substances.

In summary, understanding the solubility of 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide is crucial for its effective application. Its behavior in different solvents directly correlates to its practical utility in various chemical and pharmaceutical processes.

Interesting facts

Interesting Facts about 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide

The compound 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide is fascinating due to its unique structure and potential applications in various fields. Here are some interesting points to consider:

Unique Structure: The presence of the chloro group and the isoindolin structure contributes to its reactive properties and efficiency as a chemical agent.
Pharmaceutical Potential: Compounds like this often play a role in drug development, particularly in the design of new pharmaceuticals.
Biological Activity: Sulfonamide derivatives have been known for their antibacterial properties. This compound's structure might exhibit similar activities, making it interesting for medicinal chemistry.
Research Relevance: The compound is significant in the study of therapeutic agents that target specific biological pathways, possibly aiding in the treatment of various diseases.
Environmental Considerations: Understanding the degradation and environmental impact of such compounds is important, especially if they enter ecosystems.

As noted by famous chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This sentiment resonates well in the context of exploring complex compounds like this one, where each new discovery could lead to significant advancements in science and medicine. Through research and collaboration, the potential of such compounds continues to unfold.

The exploration of 2-chloro-5-(1-hydroxy-3-oxo-isoindolin-1-yl)benzenesulfonamide exemplifies the intersection of chemistry and biology, showcasing the intricate work that scientists undertake to harness the power of chemical compounds for the betterment of society.

Synonyms

chlorthalidone

77-36-1

Chlortalidone

Phthalamudine

Chlorphthalidolone

Hygroton

Phthalamodine

Natriuran

Chlorthalidon

Thalitone

Chlorothalidone

Chlorphthalidone

Saluretin

Zambesil

Igroton

Isoren

Oradil

Renon

Hydro-Long

Chlortalidonum

Oxodolin

Clortalidona

Oksodolin (oxodolin)

Racemic chlorthalidone

2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide

G-33182

Demi-Regroton

2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide

3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine

3-(4'-Chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine

1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline

1-Keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline

NSC-69200

2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide

G 33182

Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-

CHEBI:3654

Q0MQD1073Q

Chlortalidone [INN]

DTXSID4022812

Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-

2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide

2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide

Chlorthalidone (Chlortalidone)

MLS000069531

DTXCID902812

Clortalidone

Famolin

Higroton

Oxodoline

Urolin

NSC69200

CLORPRES COMPONENT CHLORTHALIDONE

KERLEDEX COMPONENT CHLORTHALIDONE

REGROTON COMPONENT CHLORTHALIDONE

COMBIPRES COMPONENT CHLORTHALIDONE

TENORETIC COMPONENT CHLORTHALIDONE

SMR000058635

(+-)-Hygroton

Clortalidone [DCIT]

(+-)-Chlorthalidone

LOPRESSIDONE COMPONENT CHLORTHALIDONE

DEMI-REGROTON COMPONENT CHLORTHALIDONE

2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide

CHLORTALIDONE (MART.)

CHLORTALIDONE [MART.]

Chlortalidonum [INN-Latin]

Clortalidona [INN-Spanish]

CHLORTHALIDONE (USP-RS)

CHLORTHALIDONE [USP-RS]

Hydroton

CHLORTALIDONE (EP IMPURITY)

CHLORTALIDONE [EP IMPURITY]

CHLORTALIDONE (EP MONOGRAPH)

CHLORTALIDONE [EP MONOGRAPH]

CHLORTHALIDONE (USP MONOGRAPH)

CHLORTHALIDONE [USP MONOGRAPH]

Thalitone (TN)

Hygroton (TN)

74658-80-3

Chlorthalidone (USP)

HSDB 3035

SR-01000721929

EINECS 201-022-5

NSC 69200

3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine

Chlortalidone (JAN/INN)

BRN 0312295

Chlorthalidone [USAN:USP]

UNII-Q0MQD1073Q

Oksodolin

CAS-77-36-1

NCGC00016317-01

Prestwick_759

(-)-Hygroton

MFCD00036257

Regroton (Salt/Mix)

Combipres (Salt/Mix)

Spectrum_000146

Opera_ID_138

(.+/-.)-Hygroton

Prestwick0_000351

Prestwick1_000351

Prestwick2_000351

Prestwick3_000351

Spectrum2_000099

Spectrum3_000349

Spectrum4_000957

Spectrum5_000743

Chlorthalidone (Standard)

(.+/-.)-Chlorthalidone

CHLORTALIDONE [JAN]

CHLORTHALIDONE [MI]

CHEMBL1055

SCHEMBL26234

BSPBio_000441

BSPBio_002017

CHLORTHALIDONE [HSDB]

CHLORTHALIDONE [USAN]

KBioGR_001574

KBioSS_000626

5-22-07-00602 (Beilstein Handbook Reference)

CHLORTHALIDONE [VANDF]

DivK1c_000731

SPECTRUM1500187

SPBio_000058

SPBio_002362

CHLORTALIDONE [WHO-DD]

CHLORTALIDONE [WHO-IP]

BPBio1_000487

GTPL7147

BDBM25900

HMS502E13

KBio1_000731

KBio2_000626

KBio2_003194

KBio2_005762

KBio3_001237

C03BA04

CHLORTHALIDONECHLORTHALIDONE

NINDS_000731

HMS1569G03

HMS1920M09

HMS2091E12

HMS2096G03

HMS2236D07

HMS3259H04

HMS3372A07

HMS3713G03

Pharmakon1600-01500187

Chlorthalidone - Bio-X trade mark

BCP27835

CHLORTHALIDONE [ORANGE BOOK]

Tox21_110369

CCG-38917

HY-15833R

NSC756692

s3074

STK686335

Chlortalidone 1.0 mg/ml in Methanol

CHLORTALIDONUM [WHO-IP LATIN]

AKOS005599810

Tox21_110369_1

DB00310

FC20414

KS-1342

NC00690

NSC-756692

IDI1_000731

NCGC00094616-01

NCGC00094616-02

NCGC00094616-03

NCGC00094616-04

NCGC00094616-07

AC-11367

BC300050

HY-15833

CHLORTHALIDONE COMPONENT OF CLORPRES

CHLORTHALIDONE COMPONENT OF KERLEDEX

CHLORTHALIDONE COMPONENT OF REGROTON

SBI-0051313.P003

CHLORTHALIDONE COMPONENT OF COMBIPRES

CHLORTHALIDONE COMPONENT OF TENORETIC

DB-056211

AB00051946

NS00000540

C76474

CHLORTHALIDONE COMPONENT OF LOPRESSIDONE

D00272

AB00051946_12

CHLORTHALIDONE COMPONENT OF DEMI-REGROTON

EN300-18527725

Q425289

SR-01000721929-2

SR-01000721929-3

BRD-A26384407-001-05-3

BRD-A26384407-001-15-2

BRD-A26384407-001-25-1

Z1741981513

2-Chloro-5(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide

2-Chloro-5-(1-hydroxy-3-oxo-1H-isoindolinyl)benzenesulfonamide

Chlorthalidone, European Pharmacopoeia (EP) Reference Standard

2-chloro-5-(1,3-dihydroxy-1H-isoindol-1-yl)benzene-1-sulfonamide

Benzenesulfonamide,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-

Chlorthalidone, United States Pharmacopeia (USP) Reference Standard

2-CHLORO-5-(1-HYDROXY-3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)-1-BENZENESULFONAMIDE

2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide #

2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide

2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; Higroton

Chlortalidone for peak identification, European Pharmacopoeia (EP) Reference Standard

Chlorthalidone;3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine;Hygroton

201-022-5