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2-chloro-4-nitrobenzamide

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Identification
Molecular formula
C7H5ClN2O3
CAS number
6951-49-3
IUPAC name
2-chloro-4-nitro-benzamide
State
State

Solid at room temperature, with a firm crystalline structure often used for various chemical synthesis and reactions.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
200.56g/mol
Molar mass
200.5610g/mol
Density
1.5698g/cm3
Appearence

2-Chloro-4-nitrobenzamide appears as a solid compound, typically in a crystalline or powder form. The color can range from white to a pale yellow, depending on the purity and specific batch of the substance. It is both water-insoluble and light- and air-stable under normal conditions.

Comment on solubility

Solubility of 2-chloro-4-nitro-benzamide (C7H5ClN2O3)

The solubility of 2-chloro-4-nitro-benzamide presents a fascinating aspect of its chemical behavior. Overall, the compound is known to have moderate solubility in various solvents, influenced by its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Solvent interaction: 2-chloro-4-nitro-benzamide tends to dissolve well in polar organic solvents due to its polar functional groups, including the amide group.
  • Hydrogen bonding: Its ability to form hydrogen bonds enhances its solubility in such solvents, allowing it to interact favorably with solvent molecules.
  • Aqueous solubility: In water, the solubility is relatively low, which is typical for many aromatic amide compounds due to the hydrophobic aromatic ring.
  • Temperature effect: Increasing the temperature can improve solubility in certain solvents, showcasing the temperature-dependence of solubility for this compound.

In summary, 2-chloro-4-nitro-benzamide exhibits:

  1. Moderate solubility in polar organic solvents
  2. Limited solubility in water
  3. Temperature-dependent solubility characteristics

Understanding the solubility traits of this compound is crucial for its practical applications in various chemical processes, making it a valuable topic of study!

Interesting facts

Interesting Facts about 2-Chloro-4-Nitro-Benzamide

2-Chloro-4-nitro-benzamide is a fascinating compound that holds significant interest in both synthetic and medicinal chemistry. Here are some captivating aspects of this compound:

  • Versatile Intermediate: This compound is widely used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. Its ability to introduce diverse functional groups makes it a valuable building block.
  • Active Research Focus: Due to its potential biological activity, 2-chloro-4-nitro-benzamide is often investigated for its role in developing new therapeutic agents, particularly against bacterial and fungal infections.
  • Mechanism Exploration: The presence of both a chlorine atom and a nitro group on the aromatic ring can lead to unique reactivity patterns, making it a subject of interest regarding electrophilic substitution reactions.
  • Environmental Impact: As with many nitro compounds, it is essential to study its environmental effects and degradation pathways, particularly since nitro-based compounds can often lead to hazardous byproducts.
  • Potential for Innovation: Ongoing research often seeks to modify this compound to enhance its efficacy and reduce toxicity, highlighting the compound's importance in the search for greener, more sustainable chemical processes.

In summary, 2-chloro-4-nitro-benzamide is not just a linear series of elements and bonds. Its diverse applications and the scientific inquiry surrounding it exemplify how even a single compound can play a crucial role in advancing both chemistry and medicine.

Synonyms
aklomide
2-Chloro-4-nitrobenzamide
3011-89-0
Aklomix
Alkomide
Clomide
Benzamide, 2-chloro-4-nitro-
component of Aklomix
Aklomida
Aklomidum
component of Novastat-W
Caswell No. 198A
Aclomida
Aklomidum [INN-Latin]
Aklomida [INN-Spanish]
2-Chlor-4-nitrobenzamid
2-CHLORO-4-NITRO BENZAMIDE
Aklomide [USAN:INN:BAN]
NSC 191832
NSC-191832
DTXSID3041405
B0E341RA20
AKLOMIDE [USAN]
AKLOMIDE [INN]
AKLOMIDE [MI]
EINECS 221-143-7
AKLOMIDE [MART.]
EPA Pesticide Chemical Code 298100
AKLOMIDE [GREEN BOOK]
DTXCID1021405
M & B 5921
NCGC00094557-01
Aklomidum (INN-Latin)
Aklomida (INN-Spanish)
AKLOMIDE (MART.)
Novastat
CAS-3011-89-0
SR-01000318823
MFCD00017119
UNII-B0E341RA20
Novastat-W
Aklomide (USAN/INN)
Spectrum2_001511
Spectrum3_001544
Spectrum4_000923
Spectrum5_001605
BSPBio_002988
KBioGR_001446
DivK1c_000648
SCHEMBL328368
SPECTRUM1503014
SPBio_001581
CHEMBL1450565
component of Aklomix (Salt/Mix)
HMS502A10
KBio1_000648
KBio3_002488
CHEBI:109542
component of Novastat (Salt/Mix)
NINDS_000648
HMS1922A03
HMS2092H10
Pharmakon1600-01503014
HY-B1094
component of Novastat-W (Salt/Mix)
Tox21_111296
Tox21_301142
CCG-39930
NSC191832
NSC758209
s5557
STK061509
AKOS003260176
Tox21_111296_1
CS-4682
FC41663
NSC-758209
PS-4712
IDI1_000648
NCGC00094557-02
NCGC00094557-03
NCGC00094557-04
NCGC00094557-05
NCGC00094557-06
NCGC00255040-01
SBI-0051750.P002
DB-020837
C2829
NS00028862
Aklomide, VETRANAL(TM), analytical standard
EN300-76542
C74541
D02785
AB00052299_02
SR-01000318823-1
SR-01000318823-2
BRD-K26807903-001-03-5
BRD-K26807903-001-04-3
Q27188688
Z57914246
221-143-7