Interesting facts
Interesting Facts about 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
This compound, known as 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, is a fascinating molecule that showcases the intricate relationship between structure and biological activity.
Chemical Features
- Complex Structure: The compound consists of a fused imidazole ring and a tetrazole group, both of which contribute unique properties and functionalities.
- Tetrazole Moiety: The presence of the tetrazole group often leads to increased solubility and bioactivity, playing a crucial role in pharmaceuticals.
- Chlorinated Carbon: The chlorine substitution may enhance the compound's reactivity and can influence its interaction with biological targets.
Applications
Due to its unique structural characteristics, this compound has potential applications in various fields, especially in medicinal chemistry:
- Pharmaceutical Development: Its ability to interact with biological macromolecules suggests it could lead to new therapeutic agents.
- Research Chemical: It can serve as a tool compound in research, helping scientists understand the mechanisms of disease at a molecular level.
Recognition
Compounds like this one often undergo rigorous evaluation:
- Preclinical Studies: Important for assessing safety and efficacy prior to human trials.
- Structure-Activity Relationship (SAR) Studies: Investigating how modifications to the compound can affect its biological activity.
The complexity and potential of 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol makes it an exciting subject of study. As scientists continue to explore the diverse applications of such compounds, they open up pathways for innovative drug development and a deeper understanding of chemical interactions within biological systems.
Synonyms
losartan
114798-26-4
DUP 89
allisartan
Angizaar
Losartic
Hyzaar
Cozaar
Lozap
CHEBI:6541
DUP-89
DTXSID7023227
UNII-JMS50MPO89
JMS50MPO89
Losartan (INN)
NSC-758699
HGP1405
HGP-1405
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
MFCD00865831
(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
DTXCID103227
HSDB 7043
MK-954
EC 601-329-8
NSC 758699
NCGC00095125-01
LOSARTAN [INN]
Losartan [INN:BAN]
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-
(1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
(1-((2'-(2h-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1h-imidazol-5-yl)methanol
2-BUTYL-4-CHLORO-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)IMIDAZOLE-5-METHANOL
[3H]losartan
Losartic (TN)
(1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
1H-IMIDAZOLE-5-METHANOL, 2-BUTYL-4-CHLORO-1-((2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-
2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL
[3H]-losartan
CAS-114798-26-4
SR-01000763170
lorastan
losartanum
(2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanol
2-Butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole
Losartan; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol; DUP 89; Lortaan
Losartan (Standard)
Dup89
Spectrum_001713
LOSARTAN [MI]
SCHEMBL60
LOSARTAN [VANDF]
Spectrum2_001677
Spectrum3_000998
Spectrum4_001126
Spectrum5_001466
Epitope ID:140137
LOSARTAN [WHO-DD]
Oprea1_644635
US9624243, Losartin
BSPBio_002695
GTPL590
KBioGR_001611
KBioSS_002193
Losartan - Bio-X trade mark
BIDD:GT0286
SPECTRUM1504268
SPBio_001893
GTPL3941
BDBM82258
KBio2_002193
KBio2_004761
KBio2_007329
KBio3_001915
C09CA01
PSIFNNKUMBGKDQ-UHFFFAOYSA-N
BCPP000183
BDBM318822
EX 89
HMS1922J13
HMS2093E22
HMS3715L11
Pharmakon1600-01504268
BCP27731
NSC_3961
Tox21_111435
CCG-39095
HY-17512R
NSC758699
s5067
STL419984
2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol
AKOS015917390
AKOS015994740
Tox21_111435_1
AB07507
BCP9000861
DB00678
FL39656
KS-5004
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole
NCGC00095125-02
NCGC00095125-03
NCGC00095125-05
NCGC00095125-08
NCGC00095125-10
NCGC00095125-15
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol
BL164640
HY-17512
SBI-0206766.P001
CAS_114798-26-4
L0378
NS00008822
C07072
D08146
EN300-311953
AB01563296_01
L000351
Q410074
SR-01000763170-3
SR-01000763170-4
BRD-K76205745-001-02-5
BRD-K76205745-001-04-1
BRD-K76205745-001-06-6
BRD-K76205745-237-16-5
BRD-K76205745-237-18-1
F2173-0506
Z2417557127
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]imidazole
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
(2-butyl-4-chloro-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol
{2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl}-methanol
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
2-butyl-4-chloro-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol
2-butyl-4-chloro-1-[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-ylmethyl]-1H- imidazole-5-methanol
2-butyl-4-chloro-5-(hydroxymethyl)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole
Solubility of 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
The solubility of the compound 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (C22H23ClN6O) presents an intriguing aspect for researchers and applications. This compound features a complex structure that can influence its solubility properties significantly. Here are some key points regarding its solubility:
Overall, the solubility of this compound is likely to be moderate, predominantly influenced by the ratio of polar and non-polar components in its structure. In practice, it might show better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol rather than water. As with many complex compounds, solubility testing in various solvents is crucial for practical applications.
In summary, understanding the solubility of this compound involves considering the balance of its hydrophilic and hydrophobic regions, which plays a critical role in its interactions and potential uses in different environments.