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Propranolol

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Identification
Molecular formula
C16H21BrN2O2
CAS number
318-98-9
IUPAC name
2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide
State
State

At room temperature, Propranolol is in a solid state. Its crystalline structure allows it to be ground into a fine powder suitable for pharmaceutical formulations.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
484.00
Boiling point (Kelvin)
757.15
General information
Molecular weight
259.34g/mol
Molar mass
259.3440g/mol
Density
1.4729g/cm3
Appearence

Propranolol hydrochloride is a white to off-white crystalline solid that is soluble in water and ethanol. It has no distinct smell and appears as a fine powder.

Comment on solubility

Solubility of 2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide

The solubility of the compound 2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide (C16H21BrN2O2) presents distinctive characteristics attributed to its complex structure.

Key considerations regarding solubility include:

  • Polarity: The presence of functional groups, such as hydroxyl (–OH) and amine (–NH2), significantly increases the polarity of the molecule, suggesting potential solubility in polar solvents such as water.
  • Hydrogen bonding: The ability to form hydrogen bonds through both the hydroxyl and amine groups enhances interactions with solvent molecules, potentially increasing solubility.
  • Hydrophobic regions: Given the presence of the indole and cyclohexyl moieties, there may be segments of the molecule that exhibit hydrophobic characteristics, potentially limiting solubility in aqueous environments.

In practical terms, this compound may demonstrate:

  1. Moderate solubility in polar solvents owing to its polar functional groups.
  2. Limited solubility in non-polar solvents due to hydrophobic regions present in its structure.

Ultimately, the solubility of 2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide would benefit from empirical investigation under varying conditions to fully elucidate its behavior in different solvents.

Interesting facts

Interesting Facts about 2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide

This compound, a complex organic molecule, contains a variety of functional groups that contribute to its interesting properties and potential applications. Here are some notable highlights:

  • Pharmaceutical Potential: The presence of the indole moiety suggests that this compound may be linked to various biological activities. Indole derivatives are known for their role in drug development, particularly in the field of neuropharmacology.
  • Structural Complexity: The compound's structure includes multiple functional domains, such as bromo, hydroxy, and amino groups, each of which can interact with biological systems in distinct ways.
  • Synthetic Versatility: The diverse functionalization of this compound offers numerous pathways for synthesis and modification, allowing chemists to tailor its properties for specific research or therapeutic purposes.
  • Biological Activity: Compounds like this one have been investigated for their potential to act as inhibitors or modulators in various biochemical pathways, which could have implications in the treatment of diseases.
  • Research Interest: The intricate design of this compound invites further studies into its mechanism of action, pharmacodynamics, and pharmacokinetics, essential components in drug development.

In summary, 2-bromo-N-[1-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methyl-cyclohexyl]-1-methyl-ethyl]acetamide stands out due to its complex and intriguing structure, making it a compound of interest in both chemical research and potential therapeutic applications.

Synonyms
(+/-)-Pindobind
106469-51-6
N8-Bim
2-bromo-N-[2-[4-[[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino]-4-methylcyclohexyl]propan-2-yl]acetamide
CHEMBL157881
N(8)-Bromoacetyl-N(1)-3'-(4-indolyloxy)-2'-hydroxypropyl-1,8-diamino-4-menthane
Acetamide, 2-bromo-N-(1-(4-((2-hydroxy-3-(1H-indol-4-yloxy)propyl)amino)-4-methylcyclohexyl)-1-methylethyl)-
N-(2-(4-((3-((1H-Indol-4-yl)oxy)-2-hydroxypropyl)amino)-4-methylcyclohexyl)propan-2-yl)-2-bromoacetamide
(+/-)PINDOBIND
Lopac0_000977
DTXSID20910011
( inverted question mark)-Pindobind
BDBM50226717
CCG-205057
acetamide,2-bromo-n-[1-[4-[[2-hydroxy-3-(1h-indol-4-yloxy)propyl]amino]-4-methylcyclohexyl]-1-methylethyl]-
EU-0100977
P-119
SR-01000075283
SR-01000075283-1
N8-Bromoacetyl-N1-3'-(4-indolyloxy)-2'-hydroxy-propyl-[Z]-1,8-diamino-p-methane
2-Bromo-N-{2-[4-({2-hydroxy-3-[(1H-indol-4-yl)oxy]propyl}amino)-4-methylcyclohexyl]propan-2-yl}ethanimidic acid