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2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

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Identification
Molecular formula
C16H14BrN3O3
CAS number
1044399-10-3
IUPAC name
2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
State
State

At room temperature, this compound is typically found in a solid state. Given its crystalline appearance, it is likely stable under ordinary conditions of use and storage.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
462.15
Boiling point (Kelvin)
735.30
General information
Molecular weight
388.21g/mol
Molar mass
388.2350g/mol
Density
1.6000g/cm3
Appearence

2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol appears as a brown or off-white crystalline solid. The color and consistency are typical of many aromatic compounds that contain substituents such as bromine and methoxy groups. It may display different shades due to the presence of impurities or due to light exposure, which can cause the bromine and methoxy groups to interact with the light differently.

Comment on solubility

Solubility of 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

The solubility of the compound 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (C16H14BrN3O3) can be influenced by various factors. It is essential to consider:

  • Polarity: The presence of polar groups such as -OH and -N can enhance solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl (-OH) group allows for potential hydrogen bonding, which may increase solubility in water and other protic solvents.
  • Temperature: Solubility often increases with temperature; thus, heating the solvent may enhance dissolution.
  • pH levels: The pH of the solvent may affect the ionization of the amine group, altering solubility characteristics.
  • Solvent type: The choice of solvent is critical; it may be poorly soluble in nonpolar solvents due to hydrophobic character of some groups.

In summary, the solubility behavior of this compound is multi-faceted, and understanding these factors can provide insight into its dissolution properties. Always remember, as stated, "The right solvent can make all the difference in solubility!"

Interesting facts

Interesting Facts about 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

This unique compound belongs to a class of chemical compounds known for their diverse biological activities, particularly in medicinal chemistry. Here are some key points that make 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol particularly noteworthy:

  • Structure and Functionality: The incorporation of a bromo group alongside a quinazoline moiety significantly enhances its reactivity and bioactivity, making it a point of interest in drug design.
  • Biological Implications: Compounds containing quinazoline structures are known for exhibiting various pharmacological properties, such as antitumor and antimicrobial activities, highlighting this compound's potential use in therapeutic applications.
  • Research Potential: The ongoing research around this class of compounds suggests that they could serve as critical leads for developing new pharmaceuticals, particularly in targeting specific enzymes or receptors.
  • Versatility: The presence of multiple functional groups allows for further derivatization, which can lead to the discovery of even more potent derivatives. This characteristic is invaluable in medicinal chemistry.

In the words of one research scholar, “The synergy of bromine and quinazoline groups can lead to innovative solutions in drug discovery by addressing unmet medical needs.” This encapsulates the essence of why such compounds are essential in the field of chemical and pharmaceutical research.

As you delve deeper into the study of chemical compounds, consider the intricate relationships between structure and function, and how the modification of simple molecules like 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol could pave the way for breakthroughs in treating diseases.

Synonyms
WHI-P154
211555-04-3
WHI-P 154
jak3 inhibitor ii
2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
2-bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol
PG8BT6T9MB
2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
WHIP154
WHI P154
CHEMBL473773
4-(3'-bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline
DTXSID60274407
2-bromo-4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
2-BROMO-4-((6,7-DIMETHOXY-4-QUINAZOLINYL)AMINO)PHENOL
PHENOL, 2-BROMO-4-((6,7-DIMETHOXY-4-QUINAZOLINYL)AMINO)-
MASTPROM
C16H14BrN3O3
MFCD02179366
UNII-PG8BT6T9MB
SCHEMBL29651
GTPL5993
WHI-P154?
DTXCID90225886
EX-A445
GLXC-03758
HMS3229G09
HMS3651J21
BCP09619
BDBM50248764
HB1431
s2867
AKOS024457435
CCG-206762
CS-1605
SB19297
SDCCGSBI-0086685.P004
NCGC00351598-08
AC-32054
AS-55999
BW162805
HY-13895
DB-338171
SW220243-1
W0013
JAK3 Inhibitor II - CAS 211555-04-3
SR-02000000171
SR-02000000171-1
BRD-K07487750-001-03-3
BRD-K07487750-001-04-1
Q59842480
2-Bromo-4-[(6,7-dimethoxy-4-quinazo linyl)amino]phenol
809-014-9