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Diethanolamine

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Identification
Molecular formula
C6H13NO2
CAS number
111-42-2
IUPAC name
2-[bis(2-hydroxyethyl)amino]acetic acid
State
State

At room temperature, diethanolamine is typically a liquid but can also exist as a solid if cooled below its melting point. It is known for being hygroscopic and tends to be a viscous liquid under standard conditions.

Melting point (Celsius)
28.00
Melting point (Kelvin)
301.20
Boiling point (Celsius)
268.10
Boiling point (Kelvin)
541.30
General information
Molecular weight
105.14g/mol
Molar mass
105.1350g/mol
Density
1.0971g/cm3
Appearence

Diethanolamine appears as a colorless to pale yellow, viscous liquid. It has a slight ammonia-like odor and is hygroscopic, meaning it can absorb moisture from the air. It is also known to form crystals upon cooling to its melting point.

Comment on solubility

Solubility of 2-[bis(2-hydroxyethyl)amino]acetic acid

2-[bis(2-hydroxyethyl)amino]acetic acid, commonly recognized as a glycine derivative, exhibits notable solubility properties primarily attributed to its functional groups. Understanding its solubility is crucial for various applications in biological and industrial contexts. Here are some key points regarding its solubility:

  • Soluble in Water: This compound is highly soluble in water owing to the presence of multiple hydroxyl (-OH) groups and the amino (-NH) functionality, which promote hydrogen bonding with water molecules.
  • Aqueous Solutions: In aqueous solutions, 2-[bis(2-hydroxyethyl)amino]acetic acid exists predominantly in its ionic form, enhancing its solubility even further.
  • Effect of pH: The solubility can be influenced by the pH of the solution. At lower pH levels, the protonation of the amino group increases solubility, while higher pH levels may provide a neutral or deprotonated state that is also quite soluble.
  • Organic Solvents: While significantly soluble in water, this compound tends to have limited solubility in non-polar organic solvents, which is typical of polar molecules.

Overall, the solubility of 2-[bis(2-hydroxyethyl)amino]acetic acid is a direct reflection of its polar characteristics and ability to interact favorably with water, making it a versatile compound in various scientific applications.

Interesting facts

Interesting Facts about 2-[bis(2-hydroxyethyl)amino]acetic acid

2-[bis(2-hydroxyethyl)amino]acetic acid, commonly known as beta-alanine, is a fascinating compound with significant roles in both biological systems and industrial applications. Below are some intriguing aspects that highlight its importance:

  • Biological Function: This compound serves as a crucial component in the synthesis of carnosine, a dipeptide found in muscle tissue that acts as a buffer against acid build-up during high-intensity exercise.
  • pH Regulation: Due to its ability to donate protons, beta-alanine plays an essential role in maintaining the pH balance within biological systems, which is vital for enzymatic activities.
  • Supplement Popularity: It's widely used as a dietary supplement among athletes and bodybuilders to enhance physical performance, often leading to improved endurance and reduced fatigue.
  • Synthesis Process: 2-[bis(2-hydroxyethyl)amino]acetic acid can be synthesized through a straightforward chemical process involving the reaction of glycine with formaldehyde and a suitable source of amine.
  • Industrial Applications: Besides its use in biology, this compound is also utilized in various industrial applications, including but not limited to the production of certain pharmaceuticals and the development of effective buffer solutions.
  • Research Focus: Ongoing research is exploring its potential therapeutic effects, including properties that may aid in neurological disorders and cognitive enhancement.

In conclusion, the compound 2-[bis(2-hydroxyethyl)amino]acetic acid is not just a simple amino acid derivative; its role in both health and industry makes it a subject of interest across multiple fields of study. As we explore more about this compound, it continues to unveil potential benefits and applications that are worth investigating!

Synonyms
Bicine
150-25-4
N,N-Bis(2-hydroxyethyl)glycine
Diethylolglycine
Diethanol glycine
Dihydroxyethylglycine
Bicene
N,N-Di(2-hydroxyethyl)glycine
Glycine, N,N-bis(2-hydroxyethyl)-
2-(bis(2-hydroxyethyl)amino)acetic acid
N,N-Dihydroxyethylglycine
N,N-Dihydroxyethyl glycine
Fe-3-Specific
Bis(2-Hydroxyethyl)glycine
2-[bis(2-hydroxyethyl)amino]acetic acid
N,N-(2-Hydroxyethyl)glycine
DHEG
MFCD00004295
N,N-Bis(2-hydroxyethyl)aminoacetic acid
N,N-Bis(beta-hydroxyethyl)glycine
NSC 7342
GLYCINE, N,N-DIHYDROXYETHYL-
di(hydroxyethyl)glycine
N,N-(2-Dihydroxyethyl)glycine
Diethanolglycine
2-HxG
EINECS 205-755-1
N,N-Bis(hydroxyethyl)glycine
BRN 1769362
1J484QFI1O
CHEBI:40957
NSC-7342
NSC-7512
BICINE [MI]
4-04-00-02390 (Beilstein Handbook Reference)
bicine buffer
N,N-Bis(.beta.-hydroxyethyl)glycine
N,N-DI(HYDROXYETHYL)AMINOACETIC ACID
Glycine,N-dihydroxyethyl-
N,N-BIS(HYDROXYETHYL)AMINOACETIC ACID
WLN: QV1N2Q2Q
Glycine,N-bis(2-hydroxyethyl)-
Chelest GA; DHEG;NSC 7342; NSC 7512;Diethanol glycine
UNII-1J484QFI1O
Fe3Specific
N,NDihydroxyethylglycine
N,NDihydroxyethyl glycine
Bis(2Hydroxyethyl)glycine
N,N(2Hydroxyethyl)glycine
Glycine, N,Ndihydroxyethyl
N,N-di(hydroxyethyl)glycine
N,NDi(2hydroxyethyl)glycine
SCHEMBL34161
N,NBis(2hydroxyethyl)glycine
Bicine (cell culture suitable)
di(hydroxyethyl)aminoacetic acid
N,NBis(betahydroxyethyl)glycine
CHEMBL1231251
DTXSID3041669
Glycine, N,Nbis(2hydroxyethyl)
CHEBI:39065
BICINE, >=99% (titration)
N,N-bis(2-hydroxyethyl)glycine]
NSC7342
NSC7512
N,N-bis(2-hydroxyethyl)-Glycine
HMS3604E14
n,n-bis-(2-hydroxyethyl)-glycine
HY-D0868
N,NDi(hydroxyethyl)aminoacetic acid
N,NBis(hydroxyethyl)aminoacetic acid
AC8058
BBL011024
s6276
STK802165
N,NBis(2hydroxyethyl)aminoacetic acid
AKOS005622671
DB03709
FB11031
[Bis(2-hydroxyethyl)amino]acetic acid #
BICINE, BioUltra, >=99.5% (T)
BICINE, BioXtra, >=99% (titration)
NCGC00342441-01
AS-12494
DA-55872
N,N-Bis(2-hydroxyethyl)glycine (Bicine)
N,N-Bis-(2-hydroxyethyl)aminoacetic acid
SY010805
N,N-bis-(2-hydroxyethyl) aminoacetic acid
B0484
CS-0015178
NS00003493
AB00443773-03
EN300-7244555
Q4903636
3-Azapentanoic acid, 5-hydroxy-3-(2-hydroxyethyl)-
Z336127920
205-755-1