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Quinuclidine

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Identification
Molecular formula
C7H13N
CAS number
100-76-5
IUPAC name
2-azabicyclo[2.2.2]octane
State
State

Quinuclidine is generally in a solid state at room temperature. It may appear as a crystalline solid or as a powder, often used in chemical synthesis and as a catalyst.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
149.00
Boiling point (Kelvin)
422.15
General information
Molecular weight
111.19g/mol
Molar mass
111.1870g/mol
Density
1.0230g/cm3
Appearence

Quinuclidine is a colorless crystalline solid. It is typically encountered as a white powder due to its crystalline nature. The compound is noted for its distinctive odor, which is similar to that of tertiary amines.

Comment on solubility

Solubility of 2-azabicyclo[2.2.2]octane

2-azabicyclo[2.2.2]octane, a bicyclic amine compound, exhibits unique solubility characteristics that can be attributed to its structural features. The solubility of this compound is influenced by several factors:

  • Polarity: The presence of a nitrogen atom in its structure contributes to a degree of polarity, which can facilitate interactions with polar solvents.
  • Hydrogen Bonding: As an amine, 2-azabicyclo[2.2.2]octane is capable of forming hydrogen bonds, making it generally soluble in water and other hydrogen-bonding solvents.
  • Aliphatic Character: The bicyclic nature and the aliphatic carbon framework may limit its solubility in non-polar solvents, thus indicating a preference for polar to moderately polar environments.

In summary, while 2-azabicyclo[2.2.2]octane shows considerable solubility in polar solvents due to its ability to interact through hydrogen bonding and its polarity, it tends to have limited solubility in highly non-polar solvents. As one might say, "the solubility behavior reflects the compound's molecular interactions!"

Interesting facts

Interesting Facts about 2-Azabicyclo[2.2.2]octane

2-Azabicyclo[2.2.2]octane, often referred to in scientific circles as a unique bicyclic compound, is a fascinating structure due to its distinctive bicyclic arrangement. Here are some compelling aspects of this intriguing molecule:

  • Structural Diversity: This compound features a nitrogen atom integrated into its bicyclic framework, which is uncommon and gives it unique properties and reactivity.
  • Potential Applications: The structural characteristics of 2-azabicyclo[2.2.2]octane make it an important compound in the development of pharmaceuticals, especially as it can influence the activity of certain neurotransmitter receptors.
  • Reactivity: The nitrogen within the bicyclic framework contributes to its distinctive reactivity, making it a subject of study for chemists focusing on synthesis and reaction mechanisms.
  • Natural Occurrence: Compounds similar to 2-azabicyclo[2.2.2]octane can be found in various natural products, which are essential for the development of new drugs based on these structures.
  • Inspiration for Innovation: Chemists and researchers are continually exploring the potential of this compound in creating novel materials and compounds with specific characteristics due to its unique bicyclic structure.

In summary, 2-azabicyclo[2.2.2]octane serves as a profound example of how a simple change in structure, like the incorporation of a nitrogen atom into a ring system, can lead to remarkable possibilities in both chemistry and applications in real-world scenarios. As noted by a leading chemist, “The geometry and flexibility offered by bicyclic structures like 2-azabicyclo[2.2.2]octane present endless opportunities for discovery and innovation.”

Synonyms
2-Azabicyclo[2.2.2]octane
280-38-6
Isoquinuclidine
2-AZABICYCLO(2.2.2)OCTANE
3-azabicyclo[2.2.2]octane
MFCD01664956
2-aza-bicyclo[2.2.2]octane
BRN 0103113
Isochinuclidin
SCHEMBL27542
5-20-04-00342 (Beilstein Handbook Reference)
CHEMBL1214433
SCHEMBL15192831
SCHEMBL20758936
SCHEMBL23982869
2-azabicyclo[2. 2. 2]octane
DTXSID00182279
KPUSZZFAYGWAHZ-UHFFFAOYSA-N
AKOS002678443
AKOS006350522
SB20155
AS-58429
DB-355471
CS-0054718
EN300-89472
P11101
InChI=1/C7H13N/c1-3-7-4-2-6(1)5-8-7/h6-8H,1-5H