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Paromomycin

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Identification
Molecular formula
C23H45N5O14
CAS number
7542-37-2
IUPAC name
2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol
State
State

At room temperature, paromomycin sulfate exists as a solid, particularly in a powdered form. It tends to be stable under normal atmospheric conditions when kept dry and stored in light-resistant containers to prevent potential degradation from light exposure.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
615.63g/mol
Molar mass
615.6340g/mol
Density
1.8200g/cm3
Appearence

Paromomycin sulfate typically appears as a white to off-white crystalline powder. It is hygroscopic in nature and may clump together if exposed to air for extended periods. Due to its form as a sulfate salt, it is soluble in water, forming a clear to slightly opalescent solution.

Comment on solubility

Solubility of 2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol

The compound 2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol, with the chemical formula C23H45N5O14, exhibits interesting solubility characteristics due to its complex structure.

Several factors contribute to its solubility:

  • Hydrophilicity: The presence of multiple hydroxyl groups (–OH) in the molecular structure significantly enhances hydrophilicity, leading to better solubility in polar solvents like water.
  • Amine Groups: The amine functionalities (-NH2) present in the molecule can form hydrogen bonds with water, affecting solubility positively.
  • Alkyl Chains: The longer carbon chains can introduce some hydrophobic characteristics, which may limit solubility in purely aqueous environments.

Therefore, one can summarize that:

  • Highly soluble in polar solvents (e.g., water)
  • Moderately soluble in non-polar solvents
  • Insoluble in organic solvents with low polarity

In many cases, solubility can be influenced by factors such as temperature, pH, and the presence of other solutes. To quote a common observation: "Solubility is often the key to bioavailability in pharmacology." This principle holds particularly true for this compound, making it essential for various applications where solubility plays a crucial role. Overall, understanding its solubility behavior can greatly enhance its practical applications in chemical and pharmaceutical contexts.

Interesting facts

2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol

This remarkable compound, commonly referred to as a derivative of amino sugars, plays a significant role in various fields, including medicinal chemistry and biochemistry. As a complex molecule, it features multiple functional groups that contribute to its biological activities and potential medicinal applications. Here are some intriguing facts about this compound:

  • Biological Significance: Compounds of this nature are often involved in biochemical pathways, making them critical in drug development and therapeutic strategies.
  • Structure Complexity: The structural architecture includes tetrahydropyran rings, which are known for their appearance in many natural products and their importance in carbohydrate chemistry.
  • Potential Applications: Due to its substituents, this compound has the potential to exhibit antidiabetic and antibiotic properties, which are areas of extensive research.
  • Synthetic Challenges: The synthesis of such complex molecules often requires multiple steps and careful control of reaction conditions, underlining the challenges faced by chemists in this field.
  • Hydrophilicity: The presence of hydroxymethyl groups indicates significant hydrophilicity, which may affect how the molecule interacts with biological systems and its solubility properties.

Furthermore, the combination of amine and hydroxyl functional groups provides this compound with unique reactivity, making it a point of interest for organic synthesis. As scientists continue exploring the possibilities of this compound, it reminds us of the intricate connections between molecular structure and biological function.

Synonyms
4,6-diamino-3-[(6-amino-6-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxyhexopyranoside
8063-07-8
4,6-Diamino-3-((6-amino-6-deoxyhexopyranosyl)oxy)-2-hydroxycyclohexyl 3-amino-3-deoxyhexopyranoside
Prestwick0_000394
Prestwick1_000394
Prestwick2_000394
SCHEMBL536994
SPBio_002528
CHEMBL266589
SCHEMBL22203857
SCHEMBL23463004
SCHEMBL23684893
SCHEMBL24791017
DTXSID80859033
STK249708
AKOS000715204
AKOS022074048
AK31431
NS00004957
2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl) tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-tetrahydropyran-3,4,5-triol