Skip to main content

Tenofovir

ADVERTISEMENT
Identification
Molecular formula
C9H14N5O4
CAS number
147127-20-6
IUPAC name
2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide
State
State

Tenofovir is generally a solid at room temperature, occurring as a crystalline powder.

Melting point (Celsius)
279.50
Melting point (Kelvin)
552.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
305.28g/mol
Molar mass
305.2800g/mol
Density
1.4310g/cm3
Appearence

Tenofovir generally appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide

The solubility of the compound 2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide (C9H14N5O4) can be influenced by several factors, including its structural components and the presence of various functional groups. Here are several key points to consider:

  • Hydrophobic Regions: The presence of large aromatic groups, such as the 4-methoxyphenyl moiety, often contributes to a lower solubility in polar solvents.
  • Hydrophilic Functional Groups: Conversely, the nitrogen and hydroxyl groups may enhance the solubility in polar solvents like water due to the ability to form hydrogen bonds.
  • pH Dependency: The compound's solubility may also vary with pH changes, as protonation or deprotonation of amine groups can alter its ionization states.
  • Temperature Influence: Generally, an increase in temperature leads to an increase in solubility for many organic compounds, which may apply to this compound as well.

Thus, while 2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide may exhibit moderate solubility characteristics, the specific conditions under which it is assessed will ultimately determine its practical solubility behavior. Overall, one might conclude that understanding the interplay of these factors is critical for predicting the solubility of such complex organic molecules.

Interesting facts

Exploring 2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide

This compound is a fascinating example of a synthetic small molecule that has piqued the interest of researchers in the field of medicinal chemistry, particularly for its potential therapeutic applications. Here are some intriguing facts about this compound:

  • Complex Structure: The compound features a complex, multi-ring structure that combines elements of purine, which is significant in biochemistry, particularly in relation to DNA and RNA metabolism.
  • Biological Activity: Its unique composition may allow it to interact with various biological targets, making it a subject of studies aiming to develop novel drugs for diseases such as cancer or viral infections.
  • Inhibition Potential: Compounds like this one often act as inhibitors for specific enzymes or receptors, which are crucial in the progression of certain diseases, offering pathways for pharmacological intervention.
  • Amino Group Role: The presence of the amino group at the 2-position is significant, as it may enhance the solubility and bioavailability of the compound, increasing its effectiveness as a drug.

As one delves deeper into the properties and potential uses of this compound, it is important to consider its synthesis and the methods employed to explore its pharmacodynamics. With its intricate structure and the potential to interplay with metabolic pathways, this compound exemplifies the intricate relationship between chemistry and biological systems.

Quote: "Great discoveries are made when science meets creativity, and each compound has a story waiting to be uncovered."

Synonyms
2-amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
2-Amino-N-{5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl}-3-(4-methoxyphenyl)propanamide
873075-72-0
CHEMBL320467
SCHEMBL13170049
SCHEMBL22409382
CHEBI:95357
DTXSID20858989
BRD-A38479395-001-01-0
BRD-A38479395-300-01-6
BRD-A38479395-300-02-4
BRD-A38479395-300-03-2