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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one
State
State

At room temperature, Tenofovir is in a solid state.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
310.30
Boiling point (Kelvin)
583.45
General information
Molecular weight
305.27g/mol
Molar mass
305.2730g/mol
Density
1.4930g/cm3
Appearence

Tenofovir typically appears as a white to off-white crystalline powder. It is often noted for its fine particle size and consistency.

Comment on solubility

Solubility of 2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one

The solubility of the compound 2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one, represented by the formula C9H14N5O4P, is influenced by its unique molecular structure and functional groups. Understanding its solubility is crucial for its practical applications. Here are some key points to consider:

  • Polarity: The presence of multiple hydroxyl (-OH) groups contributes to a higher polarity, often leading to increased solubility in polar solvents such as water.
  • Interactions: The potential for hydrogen bonding with solvents can enhance solubility. This could result in a favorable interaction with both aqueous and organic solvents depending on conditions.
  • Temperature Effects: Generally, increased temperature may improve solubility for many compounds. It would be essential to evaluate how temperature variations affect this particular compound's solubility.
  • pH Dependency: The solubility may also be influenced by pH levels, particularly with compounds containing ionizable groups. Understanding the compound's behavior at different pH levels can shed light on its solubility in various environments.

In conclusion, the overall solubility of 2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one may be characterized as variable, with specific conditions playing a significant role in its dissolving properties. Further studies are recommended to quantify its solubility in diverse solvents for precise applications.

Interesting facts

Interesting Facts about 2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one

This fascinating compound, commonly referred to within the realm of synthetic chemistry, possesses unique structural features and functionalities. Here are some remarkable points about this chemical:

  • The compound contains a purine base, which is foundational in the structure of nucleotides, the building blocks of DNA and RNA.
  • Its complex configuration includes a phosphine oxide, indicating potential applications in medicinal chemistry, particularly in drug design and development.
  • The inclusion of multiple hydroxy groups enhances the compound’s reactivity and solubility, contributing to its versatility in various chemical reactions.
  • It features a furodioxaphosphinine ring, which is relatively rare and interesting due to its unique heterocyclic structure.
  • This compound belongs to a class of nucleobase derivatives, which are often studied for their potential role as antiviral or anticancer agents due to their ability to interact with nucleic acids.

In addition, researchers are exploring:

  • Its potential as a *bioactive agent* in cellular processes.
  • The catalytic properties it might exhibit due to the phosphorus atom’s ability to stabilize transition states during reactions.
  • The possibility of modifying its structure to enhance therapeutic efficacy or reduce side effects.

In summary, 2-amino-9-(2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one stands as an emblem of the intricate interplay between organic chemistry and pharmaceutical innovation, promising advancements in fields range from biochemistry to drug discovery.