Skip to main content

Tenofovir

ADVERTISEMENT
Identification
Molecular formula
C9H14N5O4P
CAS number
201341-05-1
IUPAC name
2-amino-9-[2-hydroxy-6-(hydroxymethyl)-2-thioxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one
State
State

At room temperature, Tenofovir is typically found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.00
Boiling point (Celsius)
605.90
Boiling point (Kelvin)
879.10
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
2.2000g/cm3
Appearence

Tenofovir typically appears as a white to off-white crystalline powder. It is practically insoluble in water and slightly soluble in methanol.

Comment on solubility

Solubility of 2-amino-9-[2-hydroxy-6-(hydroxymethyl)-2-thioxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one

The solubility of the compound with the formula C9H14N5O4P is an intriguing subject, as it depends on various factors:

  • Polarity: The presence of multiple functional groups, including amino and hydroxyl groups, suggests that this compound is polar, which can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: The capacity to form hydrogen bonds due to hydroxyl (-OH) and amino (-NH2) groups may contribute positively to its solubility profile.
  • pH Dependency: Since the compound contains both acidic and basic groups, its solubility can vary with pH, being more soluble in either acidic or basic conditions depending on the protonation state of the functional groups.
  • Thermal Stability: Temperature can also affect solubility; typically, solubility in water increases with temperature for most compounds, but specific behaviors might depend on structural characteristics and intermolecular interactions.

In essence, while there's potential for reasonable solubility in polar solvents due to its structural features, the exact solubility profile may require empirical testing to fully understand its behavior under various conditions.

Interesting facts

Exploring 2-Amino-9-[2-hydroxy-6-(hydroxymethyl)-2-thioxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one

The compound 2-amino-9-[2-hydroxy-6-(hydroxymethyl)-2-thioxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one, often abbreviated for convenience, represents a complex structure with intriguing features that make it a subject of interest in the fields of medicinal chemistry and biochemistry.

Key Characteristics

  • Novel Biological Activity: This compound is part of a class of phosphorus-containing heterocycles known for their diverse biological activities, including potential anticancer and antiviral properties.
  • Possession of Multiple Functional Groups: The molecule showcases various functional groups such as amino, hydroxy, and thioxo, which are known to influence its chemical reactivity and interaction with biological systems.
  • Complex Structure: The intricate arrangement of rings, particularly the bicyclic phosphorus analogs, can lead to unique mechanisms of action compared to simpler drugs.

As a research-oriented compound, it embodies the idea that "nature's complexity often leads to novel therapeutic pathways." Understanding its mechanism of action might open new avenues for drug development, particularly in targeting resistant cancer types. The structure's elegance, paired with its biological potential, showcases the beauty and intricacy of molecular design.

Research and Applications

This compound could be part of ongoing studies aimed at:

  • Designing new pharmaceuticals that effectively engage with specific biological targets.
  • Exploring its potential as a scaffold for creating analogs with enhanced activity or selectivity.
  • Investigating its pharmacological properties through in vitro and in vivo assays.

In conclusion, the exploration of 2-amino-9-[2-hydroxy-6-(hydroxymethyl)-2-thioxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one is more than a chemical curiosity; it represents a promising frontier in the quest for innovative therapeutic strategies.