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6-Thioguanine

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Identification
Molecular formula
C5H5N5S
CAS number
154-42-7
IUPAC name
2-amino-7H-purine-6-thiol
State
State

At room temperature, 6-Thioguanine is in a solid state. It is generally stable under normal conditions but should be stored in a cool, dry place to avoid degradation due to moisture.

Melting point (Celsius)
335.00
Melting point (Kelvin)
608.15
Boiling point (Celsius)
170.50
Boiling point (Kelvin)
443.65
General information
Molecular weight
167.20g/mol
Molar mass
167.1990g/mol
Density
2.0100g/cm3
Appearence

6-Thioguanine typically appears as a white to pale yellow crystalline powder. It is a heterocyclic compound and is hygroscopic in nature, which means it can absorb moisture from the environment.

Comment on solubility

Solubility of 2-amino-7H-purine-6-thiol (C5H5N5S)

2-amino-7H-purine-6-thiol, also known as thioguanosine, exhibits interesting solubility properties that are significant in many chemical contexts. The solubility of this compound can be influenced by various factors such as pH, temperature, and the presence of other solutes.

Factors Affecting Solubility

  • pH Levels: The solubility is often greater in higher pH conditions, where the protonation state of the amino group can affect dissolution.
  • Temperature: Increasing temperatures typically enhance the solubility of organic compounds, including 2-amino-7H-purine-6-thiol.
  • Polarity of Solvent: This compound is generally more soluble in polar solvents due to its ability to interact via hydrogen bonding.

In summary, while 2-amino-7H-purine-6-thiol is soluble in water to some extent, its solubility can be markedly improved under certain conditions, making it crucial for applications in biochemistry and pharmacology. As with many chemical compounds, understanding these solubility dynamics is essential for practical utilization.

Interesting facts

Interesting Facts About 2-Amino-7H-Purine-6-Thiol

2-Amino-7H-purine-6-thiol, often referred to as 2-aminopurine, is a fascinating compound in the realm of biochemistry and molecular biology. It belongs to the family of purines, which are essential components of nucleic acids and play vital roles in various biological processes.

Key Features and Applications:

  • Genetic Research: 2-aminopurine is known for its ability to serve as a mutagen. In research settings, it can induce mutations in bacterial and animal cells, thereby providing insights into the mechanisms of DNA repair and replication.
  • Plant Biology: This compound can act as a growth regulator in plants, influencing cell division and differentiation. Its effects on plant growth are an area of active investigation.
  • Potential Therapeutics: Due to its structural similarity to adenine, there is interest in studying 2-aminopurine's role in antiviral therapies, particularly against viruses that rely on host cell mechanisms, leveraging nucleoside analogs.

Did You Know?

2-aminopurine:

  • Has been used effectively to explore the properties of nucleic acids.
  • Can mimic the action of adenine in various biochemical reactions, making it a valuable tool for studying purine metabolism.
  • Exhibits properties that can influence the structure of RNA, which is crucial for understanding ribonucleic function and evolution.

As chemists continue to explore this compound's utility in various fields, its role in expanding our understanding of genetic information and biochemistry is undoubtedly significant. Researchers emphasize the statement: "The study of compounds like 2-aminopurine serves as a bridge between chemistry and biology, showcasing the intricate dance of molecules that sustain life."