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2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid

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Identification
Molecular formula
C16H14N2O4
CAS number
40330-00-5
IUPAC name
2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid
State
State

At room temperature, this compound is in a solid state. It is most commonly encountered as a powder or finely divided crystalline material.

Melting point (Celsius)
280.00
Melting point (Kelvin)
553.15
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.15
General information
Molecular weight
294.30g/mol
Molar mass
294.3180g/mol
Density
1.4200g/cm3
Appearence

This compound typically presents as a tan or brownish-yellow crystalline solid. The crystalline structure is often discernible with the naked eye, and it may exhibit a faint odor.

Comment on solubility

Solubility of 2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid

The solubility of 2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid, with the chemical formula C16H14N2O4, is characterized by several important factors:

  • Polarity: This compound contains both polar and non-polar parts, which often results in moderate solubility in polar solvents like water and ethanol.
  • Acidic functional groups: The presence of carboxylic acid moiety can enhance solubility in aqueous solutions by forming hydrogen bonds with water molecules, particularly under basic conditions.
  • Temperature influence: Like many organic compounds, its solubility may increase with temperature, making it more soluble in hot solvents.
  • Complexation: The potential for chelation with metal ions can impact its solubility, either increasing or decreasing it based on the nature of the ions present.

Understanding solubility is crucial for practical applications such as drug formulation and synthesis. Always consider the specific solvent environment and conditions for optimal use!


Interesting facts

Interesting Facts about 2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid

2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid is a fascinating compound that showcases the intricate world of organic chemistry. Here are some intriguing aspects of this compound:

  • Structural Complexity: This compound features a unique blend of chromeno and pyridine moieties, which contributes to its structural diversity and potential for various chemical reactions. The combination of amino, keto, and carboxylic acid functional groups opens up many avenues for reactivity.
  • Biological Significance: Compounds that incorporate chromeno-pyridine structures are often studied for their biological activities. They may exhibit properties such as anti-inflammatory or antibacterial effects, making them potential candidates for drug development.
  • Synthetic Routes: The synthesis of this compound invites several synthetic strategies, including multi-step organic transformations. Each step can introduce new functional groups or rearrangements that enhance the compound's properties.
  • Applications in Research: Due to its unique framework, researchers might explore utilizing this compound in the study of novel materials, particularly in the fields of medicinal chemistry and material science.
  • Interesting Analogs: The vast library of related compounds often inspires the design of new derivatives, which can modify biological activity or improve solubility through structural variations.

As scientists continue to unveil the secrets of such compounds, they enhance our understanding of organic chemistry better and empower advancements in pharmaceutical research. Ultimately, compounds like 2-amino-7-isopropyl-5-oxo-chromeno[2,3-b]pyridine-3-carboxylic acid remind us of the beauty and complexity inherent in nature's molecules.

Synonyms
amlexanox
68302-57-8
Amoxanox
Aphthasol
2-Amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
Amlenanox
Amlexanoxo
Elics
AA-673
Amlexanoxum
Amlexanoxum [Latin]
Amlexanoxo [Spanish]
CHX 3673
aphtheal
CHX-3673
AA 673
2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
CCRIS 2686
UNII-BRL1C2459K
MFCD00864790
2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid
BRN 0556384
BRL1C2459K
CHEBI:31205
2-Amino-7-isopropyl-5-oxo-5H-chromeno-[2,3-b]pyridine-3-carboxylic acid
AA673;Amoxanox;CHX3673
DTXSID2022595
2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
Amlexanoxum (Latin)
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
NCGC00167472-01
Amlexanox [USAN:INN:JAN]
AMLEXANOX (MART.)
AMLEXANOX [MART.]
DTXCID902595
Aptheal
Apthera
OraRinse
OraDisc A
2-Amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Aphthasol (TN)
ANW
SMR000466352
CAS-68302-57-8
Solfa (TN)
Amlexanox (JAN/USAN/INN)
4wbo
2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno(2,3-b)pyridine-3-carboxylic acid
2-Amino-7-(1-methylethyl)-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid
Amlexanox [USAN:INN:BAN:JAN]
2-amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3b)pyridine-3-carboxylic acid
Amlexanox (Standard)
AMLEXANOX [INN]
AMLEXANOX [JAN]
AMLEXANOX [MI]
AMLEXANOX [USAN]
AA-673(Amlexanox)?
AMLEXANOX [VANDF]
AMLEXANOX [WHO-DD]
CHEMBL1096
SCHEMBL29642
MLS000759466
MLS001424059
MLS006010129
BIDD:GT0709
Amlexanox - Bio-X trade mark
US10214536, Amlexanox
GTPL7113
AMLEXANOX [ORANGE BOOK]
Amlexanox, >=98% (HPLC)
HY-B0713R
A01AD07
R03DX01
WLZ3532
BDBM357857
HMS2051F13
HMS2235M08
HMS3393F13
HMS3715B14
BCP28222
HY-B0713
Tox21_112476
2-Amino-7-isopropyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic Acid
s3648
2-Amino-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylicacid
AKOS015900498
Tox21_112476_1
AC-1192
CCG-100953
DB01025
DS-1396
FA17873
NC00203
NCGC00167472-02
NCGC00167472-03
NCGC00167472-14
BA164161
SY053135
1ST163085
A2401
NS00068066
D01828
AB00639947-06
AB00639947_08
EN300-7361924
L001037
Q695611
BRD-K29530284-001-06-2
BRD-K29530284-001-07-0
Amlexanox, United States Pharmacopeia (USP) Reference Standard
2-Amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b] pyridine-3-carboxylic acid
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid Amoxanox AA-673 CHX-3673 Aphthasol Elics Solfa
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid;AA-673
5H-(1)BENZOPYRANO(2,3-.BETA.)PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-7-(1-METHYLETHYL)-5-OXO-
5H-(1)BENZOPYRANO(2,3-beta)PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-7-(1-METHYLETHYL)-5-OXO-
AA-673;2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid