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Riluzole

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Identification
Molecular formula
C8H8N2O2
CAS number
1744-22-5
IUPAC name
2-amino-5-phenyl-oxazol-4-one
State
State

Riluzole is generally found in a solid state at room temperature.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
378.50
Boiling point (Kelvin)
651.60
General information
Molecular weight
234.25g/mol
Molar mass
234.2460g/mol
Density
1.3870g/cm3
Appearence

Riluzole is a white to slightly yellow crystalline powder.

Comment on solubility

Solubility of 2-amino-5-phenyl-oxazol-4-one (C8H8N2O2)

The solubility of 2-amino-5-phenyl-oxazol-4-one is an intriguing characteristic that combines its chemical structure with the influence of various solvents. This compound is known to exhibit moderate solubility in a range of solvents, which is an essential factor for its applications.

Factors Influencing Solubility:

  • Polarity of the Solvent: The polarity of the solvent plays a crucial role in determining the solubility. Polar solvents like water typically enhance solubility for polar compounds.
  • Presence of Functional Groups: The amino and oxazole functional groups contribute to the hydrogen bonding potential, affecting solubility characteristics.
  • Temperature: Increasing temperature often increases solubility, a principle that applies to many organic compounds, including this one.

While 2-amino-5-phenyl-oxazol-4-one readily dissolves in organic solvents, its solubility in water may be limited, leading to an interesting balance in its application potential. This property is particularly relevant when considering formulations in pharmaceutical and biochemical contexts. As with many compounds, the specific conditions must be taken into account to optimize solubility for desired uses.

In summary:

  • The solubility of C8H8N2O2 depends heavily on solvent choice.
  • Combination of polar and non-polar characteristics impacts how and where this compound can be utilized.
  • A further understanding of solubility can lead to enhanced applications in various fields, including drug development.
Interesting facts

Interesting Facts about 2-amino-5-phenyl-oxazol-4-one

2-amino-5-phenyl-oxazol-4-one is a fascinating compound that finds its significance in various fields, particularly in medicinal chemistry and organic synthesis. Here are some key points that highlight its importance:

  • Structural Highlights: This compound features a unique oxazole ring, which is a heterocyclic structure comprising nitrogen and oxygen. This ring system is known for its ability to stabilize reactive intermediates and participate in a range of chemical reactions.
  • Biological Activity: Compounds containing the oxazole moiety exhibit a wide variety of biological activities. In particular, 2-amino-5-phenyl-oxazol-4-one has been studied for its potential as an antibacterial and antifungal agent. Research continues in revealing its therapeutic potentials.
  • Synthetic Versatility: The synthesis of this compound can be achieved through several methods, including condensation reactions and cyclization processes. This versatility makes it an excellent intermediate in organic synthesis.
  • Research Interest: Its derivatives may have applications in developing new pharmaceuticals and agrochemicals. Scientists are continually exploring how modifications to the oxazole core can enhance activity and selectivity against target pathogens.
  • Literature Scope: You can often find 2-amino-5-phenyl-oxazol-4-one discussed in **peer-reviewed articles** dedicated to medicinal chemistry, and its presence is frequently noted in chemical databases, which illustrates its prevalence in ongoing research activities.

In summary, 2-amino-5-phenyl-oxazol-4-one not only showcases the beauty of heterocyclic chemistry but also emphasizes the potential healthcare applications resulting from its unique chemical structure. As research progresses, it will be intriguing to see how this compound and its analogs contribute to advancements in both science and medicine.

Synonyms
pemoline
Phenoxazole
Phenylisohydantoin
Azoksodon
Fenoxazol
Azoxodon
Dantromin
2152-34-3
Cylert
Pemolin
Tradon
Azoxodone
Centramin
Deltamine
Hyton
Nitan
Kethamed
Sigmadyn
Stimulol
Okodon
Pioxol
Pondex
Sistra
Stimul
Tradone
Volital
Ronyl
Phenylpseudohydantoin
Pheniminooxazolidinone
Betanamin
Deltamin
Myamin
Constimol
Endolin
Pemolina
Phenalone
Phenilone
Pomoline
Volitol
Notair
Hyton asa
Juston-Wirkstoff
Senior
Sistral
Sofro
2-Imino-5-phenyl-4-oxazolidinone
Pemolinum
Yh 1
4(5H)-Oxazolone, 2-amino-5-phenyl-
NPL 1
2-Amino-5-phenyl-4(5H)-oxazolone
Abbott 13397
2-amino-5-phenyl-1,3-oxazol-4-one
5-Phenylisohydantion
5-Phenyl-2-imino-4-oxazolidinone
5-Phenyl-2-imino-4-oxooxazolidine
2-Amino-5-phenyl-1,3-oxazol-4(5H)-one
NSC-25159
4-Oxazolidinone, 2-imino-5-phenyl-
CHEBI:7953
Pn/135
FWH-352
2-Imino-4-keto-5-phenyltetrahydrooxazole
LA 956
PT 360
NSC-169499
2-amino-5-phenyl-4-oxazolone
YH-1
101053-01-4
DTXSID3023427
2-Amino-5-phenyl-oxazol-4-one
H 310
CS 293
LA-956
PIO
A 13397
2-Oxazolin-4-one, 2-amino-5-phenyl-
7GAQ2332NK
DTXCID503427
Fio
C- 293
H 3104
NSC25159
2-amino-5-phenyl-2-oxazolin-4-one
NSC169499
5-PHENYL-2-IMINOOXAZOLIDIN-4-ONE
2-IMINO-4-OXO-5-PHENYLOXAZOLIDINE
PEMOLINE (MART.)
PEMOLINE [MART.]
WLN: T5OYMV EHJ BUM ER
5-Phenyl-2-imino-4-oxazolidine
Pemoline (1 mg/mL in Methanol)
P 10
SMR000238142
CAS-2152-34-3
4-Oxo-2-imino-5-phenyloxazlidine
PEMOLINE [HSDB]
PEMOLINE [USAN]
PEMOLINE [INN]
PEMOLINE [JAN]
PEMOLINE [MI]
PEMOLINE [VANDF]
PEMOLINE [WHO-DD]
CHEMBL1177
SCHEMBL41636
MLS000759491
MLS001424026
PEMOLINE [ORANGE BOOK]
Pemoline, >=98% (HPLC)
NRNCYVBFPDDJNE-UHFFFAOYSA-
N06BA05
HMS2051C08
HMS3393C08
2-Amino-5-phenyl4(5H)-oxazolone
5-Phenyl-2-imino-4-oxo-oxazolidin
Tox21_112509
BDBM50248019
MFCD00083197
AKOS005065730
AKOS015888248
Tox21_112509_1
2-azanyl-5-phenyl-1,3-oxazol-4-one
CCG-100848
DB01230
NC00098
NCGC00246967-01
NCGC00246967-02
AC-22513
AS-17043
C-293
NS00007835
P0392
2-Amino-5-phenyl-1,3-oxazol-4(5H)-one #
C07899
A800319
A815446
218-438-8
InChI=1/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)