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3-Aminophosphonopropionic acid

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Identification
Molecular formula
C3H8NO4P
CAS number
1069-04-1
IUPAC name
2-amino-3-phosphono-propanoic acid
State
State

At room temperature, 3-Aminophosphonopropionic acid is in a solid state. It is a stable compound under normal conditions and not hygroscopic.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
155.07g/mol
Molar mass
155.0670g/mol
Density
2.1730g/cm3
Appearence

3-Aminophosphonopropionic acid appears as a white or off-white crystalline solid. It is odorless and typically available in powder form.

Comment on solubility

Solubility of 2-amino-3-phosphono-propanoic acid

2-amino-3-phosphono-propanoic acid, with the chemical formula C3H8NO4P, is known for its considerable solubility in water. This characteristic is primarily due to the presence of:

  • Amino groups (-NH2)
  • Phosphono groups (-PO3H2)
  • Carboxylic acid groups (-COOH)

These functional groups are polar and can form hydrogen bonds with water molecules, significantly enhancing its solubility. The solubility of this compound can be described by the following points:

  1. It readily dissolves in aqueous solutions, making it a useful reagent in biochemical experiments.
  2. Its solubility is influenced by temperature, with increased temperatures typically leading to higher dissolution rates.
  3. Despite its solubility in water, precipitate formation can occur at low pH levels, showcasing its sensitivity to environmental conditions.

In summary, 2-amino-3-phosphono-propanoic acid is highly soluble in water due to its polar functional groups, enabling a range of applications in chemical and biological systems.

Interesting facts

Interesting Facts about 2-Amino-3-phosphono-propanoic Acid

2-Amino-3-phosphono-propanoic acid, often abbreviated as APPA, is a fascinating compound in the world of biochemistry and neuroscience. This amino acid derivative is known for its unique structure and significant role in various biological processes.

Biological Significance

Here are some key points highlighting the importance of APPA:

  • Neurotransmission: APPA is a potent agonist of the metabotropic glutamate receptor, which plays a vital role in neurotransmission.
  • Research Potential: Due to its action on glutamatergic pathways, APPA is being explored for its potential therapeutic applications in treating neurological disorders, such as Alzheimer's and Parkinson's disease.
  • Inhibition of Excitotoxicity: Excitotoxicity, which results from excessive neurotransmitter release, is implicated in several neurodegenerative diseases. APPA shows promise in mitigating these effects.

Chemical Properties

The structure of 2-amino-3-phosphono-propanoic acid includes:

  • Amino group (-NH2) contributing to its role as an amino acid.
  • Phosphonic acid group (-PO3H2) which is crucial for its biological activity.
  • Carboxylic acid functional group that is a characteristic feature of amino acids.

This unique combination allows APPA to interact with a variety of biological molecules, making it a subject of interest in studies related to neuropharmacology.

Conclusion

In summary, 2-amino-3-phosphono-propanoic acid is an important compound that bridges the fields of chemistry and biology. With ongoing research, scientists are continuously uncovering new aspects of its functionality and potential, highlighting the compound's significance in understanding and treating complex neurological conditions.

Synonyms
5652-28-8
2-amino-3-phosphonopropanoic acid
2-Amino-3-phosphonopropionic acid
3-phosphonoalanine
Phosphonoalanine
DL-AP3
20263-06-3
DL-2-Amino-3-phosphonopropionic acid
2-Amino-3-phosprop
Alanine, 3-phosphono-
2-Amino-3-phosphonopropionate
2-amino-3-phosphono-propanoic acid
3-Phosphono-DL-alanine
D,L-2-Amino-3-phosphonopropionic acid
2-Amino-3-phosphopropionic acid
(+/-)-2-Amino-3-phosphonopropionic acid
2-Amino-3-phosphono-propionic acid
D-Alanyl-phosphate
2-Amino-3-phosphonopropanoate
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
MFCD00014350
NSC 30078
NSC-30078
NSC133887
0H89G8110O
AP-3
CHEBI:28388
DTXSID40863590
2-AP3
1-amino-propan-2-one-3-phosphate
2-azanyl-3-phosphono-propanoic acid
(+/-)-2-AMINO-3-PHOSPHONOPROPANOIC ACID
PHOSPHONIC ACID, (2-AMINO-2-CARBOXYETHYL)-
DL-Alanine, 3-phosphono-
DL-2-Amino-3-phosphonopropionate
Propanoic acid, 2-amino-3-phosphono-
NSC 30078; Phosphonic acid, (2-amino-2-carboxyethyl)-; alpha-Amino-beta-phosphonopropionic acid
DL-2-Amino-3-phosphonopropanoic acid
bmse000932
Lopac0_000067
CHEMBL88621
SCHEMBL195643
DL-AP-3?
UNII-0H89G8110O
2-amino-3-phosphonopropanoicacid
BDBM85077
( inverted question mark)-AP-3
DTXCID80812183
HMS3260M15
EX-A7667
FAA65228
NSC_3857
NSC30078
Tox21_500067
STL556264
AKOS015892997
(y)-2-Amino-3-phosphonopropionic acid
CCG-204162
LP00067
SDCCGSBI-0050055.P003
(?)-2-Amino-3-phosphonopropionic acid
NCGC00015063-03
NCGC00015063-04
NCGC00015063-05
NCGC00015063-06
NCGC00015063-09
NCGC00024477-02
NCGC00024477-03
NCGC00024477-04
NCGC00260752-01
NCI60_000747
3-Phosphono-D,L-2-aminopropionic acid, 7
CAS_23052-80-4
DB-045140
DB-216963
HY-100786
CS-0020425
EU-0100067
NS00123076
DL-2-Amino-3-phosphonopropionic acid (AP3)
A 4910
C05672
G76698
SR-01000075416
SR-01000075416-1
Q27236782
( inverted question mark)-2-Amino-3-phosphonopropionic acid
2B25DA57-4877-4D7E-B7F2-02DA27BA5498
D,L-2-Amino-3-phosphonopropionic acid (H-DL-Ala(PO3H2)-OH)
NSC 30078; Phosphonic acid, (2-amino-2-carboxyethyl)-; -Amino--phosphonopropionic acid
633-843-3