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Thyroxine

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Identification
Molecular formula
C15H11NO4I4
CAS number
51-48-9
IUPAC name
2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid
State
State

Thyroxine is typically a solid at room temperature, given its crystalline powder form. This is its stable state under normal atmospheric conditions.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
610.00
Boiling point (Kelvin)
883.15
General information
Molecular weight
776.87g/mol
Molar mass
776.8700g/mol
Density
2.3510g/cm3
Appearence

Thyroxine is a white to pale brown crystalline powder. The substance is odorless and has a slightly bitter taste. Its crystalline form reflects light, sometimes giving a shiny appearance under intense light.

Comment on solubility

Solubility of 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid

The solubility of 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid (C15H11NO4I4) can be quite intriguing due to its complex structure and numerous substituents. Here are some important aspects to consider:

  • Polarity: The presence of both amino (-NH2) and hydroxyl (-OH) groups contributes to a degree of polarity, possibly enhancing its solubility in polar solvents like water.
  • Iodine Substituents: With four iodine atoms embedded in the structure, the compound may exhibit hydrophobic characteristics that could limit its solubility in aqueous media.
  • Solvent Interaction: It is likely to be more soluble in organic solvents, particularly those with low polarity, given the bulky iodine atoms.
  • pH Dependence: The solubility may vary with pH, as changes in acidity can influence the ionization of the amino and carboxylic acid functional groups.

In conclusion, while pH and solvent choice play a significant role in the solubility of this compound, it is essential to consider the balance between its polar and non-polar characteristics. The solubility behavior can be considered versatile yet challenging due to the presence of both hydrophilic and hydrophobic groups, making it an interesting subject for further investigation.

Interesting facts

Interesting Facts about 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid

2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid is a fascinating chemical compound that possesses unique properties and potential applications. Here are some noteworthy insights:

  • Complex Structure: The compound features multiple functional groups, including amino, hydroxy, and multiple iodine atoms. This complexity can lead to interesting interactions with other molecules.
  • Medicinal Potential: Due to its structure, this compound might exhibit properties similar to those of therapeutic agents. Compounds containing iodine are often studied for their potential in various therapies, including cancer treatments.
  • Environmental Impact: The presence of iodine atoms can impact how the compound behaves in the environment. Iodinated compounds may have unique environmental persistence and bioaccumulation characteristics.
  • Role in Research: Researchers often analyze compounds like this one to study the effects of iodine substitution in organic molecules, particularly in pharmaceuticals, where the modification of biological activity is of great interest.
  • Potential Uses: Beyond medicinal applications, there may be uses in imaging techniques, especially in areas where iodine plays a crucial role.

In summary, 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid is a compound with a rich profile that offers numerous avenues for exploration in both chemistry and medicine. Its intricate design encourages ongoing research, expanding our understanding of iodine-containing compounds.

Synonyms
DL-Thyroxine
300-30-1
Thyroxine, dl-
2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
CHEBI:30660
QR0BV3BRIA
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine
2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid
Levothyroxine;T4
D-T4; D-Thyroxine
UNII-QR0BV3BRIA
THX
EINECS 206-088-9
Monosodium thyroxine
3,3',5,5'-Tetraiodo-DL-thyronine
T4 (pharmaceutical)
NSC36397
Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
DL-THYROXINE [MI]
Epitope ID:122661
SCHEMBL26147
CHEMBL42115
SGCUT00139
3,5,5'-Tetraiodo-L-thyronine
DTXSID0023662
BDBM398048
HMS3656A22
US10322118, Entry 6
ALBB-014128
BCP34411
SYB78014
to_000083
NSC259940
STL481965
AKOS003348790
AKOS016344683
NCGC00094852-01
NCGC00094852-02
NCGC00094852-04
7488-70-2
L-Tyrosine,5-diiodophenyl)-3,5-diiodo-
LS-04434
DB-230290
NS00075564
dl-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
DL-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
L-Tyrosine,5-diiodophenyl)-3,5-diiodo-, monosodium salt
(.+/-.)-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylalanine #
(+/-)-3-(4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL)ALANINE
2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid