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kynurenine

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Identification
Molecular formula
C10H12N2O3
CAS number
343-65-7
IUPAC name
2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid
State
State

At room temperature, kynurenine is typically found in a solid state. It is stable under normal conditions but should be protected from excessive moisture to maintain its integrity.

Melting point (Celsius)
93.00
Melting point (Kelvin)
366.15
Boiling point (Celsius)
314.00
Boiling point (Kelvin)
587.15
General information
Molecular weight
208.21g/mol
Molar mass
208.2120g/mol
Density
1.3450g/cm3
Appearence

Kynurenine is typically a crystalline powder. The compound can sometimes be off-white or slightly yellow in color due to impurities or exposure to air, which may lead to slight oxidation. It is known to be hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid

The compound 2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid, with the chemical formula C10H12N2O3, exhibits notable solubility characteristics that are worth highlighting.

Key Solubility Features:

  • Polar Functional Groups: The presence of amino (-NH2) and hydroxyl (-OH) groups significantly enhances its solubility in polar solvents, particularly water.
  • Influence of pH: The solubility of this compound can be influenced by the pH of the solution, as changes in pH can affect the ionization state of the amino and carboxylic acid groups.
  • Hydrogen Bonding: Its ability to form hydrogen bonds with water molecules facilitates its dissolution, making it relatively soluble compared to non-polar compounds.
  • Limitations: While it is soluble in water, it may have limited solubility in non-polar organic solvents due to its polar nature.

In summary, 2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid demonstrates good solubility in aqueous environments due to its polar functional groups, but its solubility in organic solvents may vary significantly. Understanding these solubility dynamics is crucial for applications in chemical synthesis and pharmaceutical development.

Interesting facts

Interesting Facts About 2-Amino-3-(3-Hydroxy-4-Oxo-1-Pyridyl)propanoic Acid

2-Amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid, often referred to as a derivative of pyridine, features unique properties that contribute to its significance in various fields, particularly in medicinal chemistry. Here are some notable aspects:

  • Biological Relevance: This compound is of interest due to its potential role in biologically relevant processes. Its structure suggests it might be involved in enzymatic reactions, particularly as an inhibitor or substrate in metabolic pathways.
  • Pyridine Derivative: As a pyridine derivative, it shares the aromatic characteristics typical of nitrogen-containing heterocycles, which are crucial for drug design. Pyridine motifs are often found in many pharmaceuticals and agrochemicals.
  • Functional Groups: The presence of the hydroxy and amino groups enhances its polarity, enabling interactions with enzymes and receptors in biological systems, thus implying potential therapeutic applications.
  • Research Applications: Due to its structure, researchers are exploring its applications in developing new drug candidates, especially in areas targeting neurological diseases, where modulation of neurotransmitter activity is crucial.
  • Innovation in Synthesis: The synthetic pathways to obtain this compound involve reactions that can be elegantly showcased in organic chemistry courses, emphasizing techniques such as nucleophilic substitution and functional group transformations.

In summary, the study of 2-amino-3-(3-hydroxy-4-oxo-1-pyridyl)propanoic acid exemplifies how intricate organic structures can lead to valuable discoveries in chemistry and pharmaceutical sciences. As researchers continue to investigate its properties, we may uncover even more applications that underscore the importance of such compounds in modern science.

Synonyms
Mimosine
2116-55-4
DL-Mimosine
2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid
10182-82-8
Mimosine, (+/-)-
2-amino-3-(3-hydroxy-4-oxopyridin-1-yl)propanoic acid
X9W047UL80
NSC69188
NSC159548
NSC-159548
1(4H)-Pyridinealanine, 3-hydroxy-4-oxo-
2-AMINO-3-(3-HYDROXY-4-OXO-PYRIDIN-1-YL)PROPANOIC ACID
2-amino-3-(3-hydroxy-4-oxo-1,4-dihydropyridin-1-yl)propanoic acid
3-(3-Hydroxy-4-oxopyridin-1(4H)-yl)alanine
Leucenine;Leucenol
Prestwick_830
(+/-)-mimosine
Spectrum_000287
starbld0038733
MIMOSINE, DL-
Prestwick0_000379
Prestwick1_000379
Prestwick2_000379
Spectrum2_000656
Spectrum3_000722
Spectrum4_000110
Spectrum5_001484
SCHEMBL41924
BSPBio_002244
KBioGR_000440
KBioSS_000767
DivK1c_001000
SPECTRUM1500869
UNII-X9W047UL80
SPBio_000691
SPBio_002458
MIMOSINE DL-FORM [MI]
CHEMBL251433
CHEBI:95190
HMS503G21
KBio1_001000
KBio2_000767
KBio2_003335
KBio2_005903
KBio3_001464
DTXSID80950337
WLN: T6N DVJ A1YZVQ CQ
NINDS_001000
HMS1569K19
HMS1921M08
HMS3744K15
Leucena glauca .alpha.-amino acid
1(4H)-Pyridinepropionic acid, .alpha.-amino-3-hydroxy-4-oxo-
BCP13303
CCG-38561
STL564778
1(4H)-Pyridinepropanoic acid, (S)-
AKOS006228368
NSC 159548
SDCCGMLS-0066728.P001
IDI1_001000
NCGC00094870-01
NCGC00094870-02
NCGC00094870-03
NCGC00178740-01
NCI60_032990
DB-134434
CS-0119397
NS00043037
Q27166999
1(4H)-Pyridinepropanoic acid, alpha-amino-3-hydroxy-4-oxo-
1-L-alpha-Aminopropionil, 3-hydroxi, 4-oxopiridina [Spanish]
2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoic acid
.beta.-[N-(3-Hydroxy-4-pyridone)]-.alpha.-aminopropionic acid
1(4H)-Pyridinepropanoicacid, a-amino-3-hydroxy-4-oxo-, (aS)-
1(4H)-PYRIDINEPROPANOIC ACID, .ALPHA.-AMINO-3-HYDROXY-4-OXO-
1(4H)-Pyridinepropanoic acid, alpha-amino-3-hydroxy-4-oxo-, (+-)-
propanoic acid, 2-amino-3-(1,4-dihydro-3-hydroxy-4-oxo-1-pyridyl)-
27678-82-6